Digital Twins: The End of Human Drug Testing for Biohackers  : 1342

Digital Twins: The End of Human Drug Testing for Biohackers : 1342

AI is transforming medicine at a speed never seen before. In this episode, you’ll discover how digital twins and artificial intelligence will revolutionize drug discovery, eliminate human trials, and personalize your biology for longevity and high performance. Host Dave Asprey breaks down how AI can now simulate virtual cells and tissues, running clinical experiments in minutes instead of years to create truly individualized medicine.


Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR


Dr. Derya Unutmaz is a world-renowned immunologist, systems biologist, and professor at The Jackson Laboratory. With more than 150 scientific papers, he’s a leading expert in immune system research and one of the first scientists to pioneer the concept of digital twins for biology. His groundbreaking work uses AI to model how immunity, metabolism, and aging interact—creating new possibilities for personalized medicine, disease prevention, and lifespan extension.


Host Dave Asprey and Dr. Unutmaz reveal how AGI will soon outperform doctors, accelerate functional medicine, and optimize human biology far beyond today’s standards. You’ll learn how the immune system drives inflammation and aging, how to re-engineer it for resilience, and why compounds like GLP-1 and metformin may add years to your life.


You’ll Learn:

• How digital twins will end human drug testing

• Why AGI could replace doctors and computer jobs within five years

• How AI models immune function, metabolism, and aging

• The role of mitochondria and inflammation in longevity

• How GLP-1 drugs and metformin extend lifespan

• What continuous biological monitoring means for health tracking

• How AI is transforming functional medicine and personalized care

• Why NAD and energy metabolism are key to human performance


They explore how artificial intelligence, biohacking, and systems biology intersect to create a smarter approach to health and longevity. You’ll also learn how understanding immune balance, metabolism, and mitochondrial function helps build resilience and extend your lifespan.


This is essential listening for anyone serious about biohacking, hacking human performance, and extending longevity through personalized medicine, functional biology, and cutting-edge AI innovation.


This is essential listening for anyone serious about biohacking, hacking human performance, improving mobility, and extending longevity. You’ll also learn how neuroplasticity, metabolism, and brain optimization all connect to the way you move.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.


New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: AI medicine, Digital twins, Functional medicine, Biohacking, Longevity, Immune system, Inflammation, Personalized medicine, GLP-1 therapy, Metformin, NAD boosters, Mitochondrial function, Metabolism, AGI, Clinical trials, Human performance, Aging research, Systems biology, Immunology, Smarter Not Harder


Thank you to our sponsors!


Resources:

• Keep up with Derya’s work: https://x.com/derya_?lang=en

• Business of Biohacking Summit | Register to attend October 20-23 in Austin, TX https://businessofbiohacking.com/

• Danger Coffee: https://dangercoffee.com/discount/dave15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

00:00 — Trailer

01:25 — Intro

02:26 — AI’s Role in Extending Lifespan

02:56 — Regulatory Frameworks and Medical Adoption

05:19 — Problems with the Immune System

08:19 — Chronic Fatigue and Long COVID Research

10:32 — Modern Testing and Multi-Omic Analysis

14:07 — Personal Longevity Strategy and Supplements

15:17 — Understanding Exhausted Cells

23:43 — Personalization in Medicine and AI Analysis

31:35 — Longevity Escape Velocity

36:13 — AI Doctors and Prescriptions

39:55 — Data Quality Concerns in AI Training

43:19 — The Future of Wearable Technology

45:50 — Revolutionizing Education with AI

49:04 — The Future of Higher Education

52:03 — Future of Work and AI Agents

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Jaksot(1437)

#45: Q & A More on Coffee, Kale, & Adrenal Fatigue

#45: Q & A More on Coffee, Kale, & Adrenal Fatigue

Questions Asked in the Podcast:   1:20 What is the best way to store Bulletproof Coffee and can you pre-grind it and store it? 4:10 For people who like to do heavy workouts several times a week what do you recommend for  recovery and muscle building? 5:30 What's the deal with drugs, specifically marijuana? Is it Bulletproof? 7:14 What about marijuana by products like Hemp protein powder or Hemp seed oil? 8:44 How can I get a Bulletproof T-shirt like the one Dave had on the Joe Rogan Experience? (bulletproofexec.com/shirts) 10:01 What are the differences between the new Bulletproof Upgraded Brain Octane Oil and the Bulletproof MCT Oil? Does the Octane Oil replace the MCT Oil or is it mean to be an addition? 13:10 Can I add the Upgraded Whey into my coffee without pushing myself out of ketogenesis? 14:28 Why is there no Certified Organic label on the MCT Oil? 15:10 How do you make a proper iced ,and blended iced, Bulletproof coffee without the fat sticking to the sides or globbing together? 16:22 Is taking Bioidentical growth hormone safe? 17:34 In the Kale Shake you list raw eggs as a potential addition, would eggshells work as well? 18:49 I massage my kale before blending or sauteing it, do I still need to stew this before steaming, or should I just cut the massage out altogether? Also are the oxalates in baby kale less? 19:43 Should I make a kale shake in addition to or in lieu of Bulletproof coffee? 20:35 Are kale chips Bulletproof? 22:19 Why is Bulletproof Coffee NOT affected by the coffee fungus problem? 24:21 Changing your diet making you stinky? 26:40 Activated charcoal and its benefits 30:24 How do I recover if I have a cheat meal from the Bulletproof Diet? 32:03 How to schedule Bulletproof Coffee and Diet around a crazy sleep schedule 35:30 Can I substitute kale with broccoli to avoid the toxins? 35:50 Adrenal Fatigue, how do you know you have it, what are some common causes, and how do I make it better? 39:35 How do you gain weight while Bulletproof? 42:35 Biohacks of the week and other conversation...   See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

10 Kesä 201349min

Bonus: Client Review with Jonathan Kos

Bonus: Client Review with Jonathan Kos

Jonathan Kos is an IT professional and a recent follower of the Bulletproof Diet.  He is a 44 year old IT professional . At 6' 3" and a former college athlete that played football, competitive ice hockey up until the age of 25 he was an extremely fit 220 lbs and my coaches wanted me up to 275 or so to play the defensive line so I was eating literally non stop to put weight on. After college he dropped down to around 200 lbs and eventually settled at for me was a healthy 235.  As he got older and more settled in his job, his weight climbed and he couldn’t keep his weight in check with exercise alone and he started to have to diet he was up to 300 lbs and was exercising more that ever but the weight didn’t come off. After he met his wife, exercise was out the window, a carb heavy diet was in, and his weight ballooned up to 365lbs. He was about to give up until he heard Tait Fletcher on Joe Rogan's podcast mentioning Bulletproof ® Coffee and he gave it a shot. He lost 45lbs in 45 days, and is here to share his experience with you.  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Kesä 201311min

#44: Salt and self-experimentation with Greg Pomerantz

#44: Salt and self-experimentation with Greg Pomerantz

For Greg Pomerantz everything is a science experiment. He takes citizen science to a personal level by biohacking his blood pressure and detailing his data. He blogged about his self-experiment research on salt clarifying some concerns he had about salt’s effect on the body. He determined what his salt type is, either one is salt sensitive, or one that isn’t affected much by increases in salt. He discusses how to do that in today’s podcast. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Kesä 201337min

#43: Kelly Starrett, Mobility and Performance

#43: Kelly Starrett, Mobility and Performance

Coach Kelly Starrett received his Doctor of Physical Therapy in 2007 from Samuel Merritt College in Oakland, California. He currently runs his own physical therapy practice at San Francisco CrossFit—one of the first 50 CrossFit affiliates—and focuses on performance-based Orthopedic Sports Medicine with an emphasis on returning athletes to elite level sport and performance. His clients see exceptional results from his progressive blend of manual physical therapy and strength training. Since 2009, Kelly has been traveling the country teaching his "Movement, Mobility & Maintenance Course" in an effort to spread his message that good mobility and proper movement are the keys to good performance and that all humans should be able to perform this basic maintenance on themselves. Kelly's clients have included Olympic gold-medalists, Tour de France cyclists, world-class extreme skiers and X-Games medalists, dancers with Smuin, San Francisco, and Sacramento Ballet Companies, military personnel, and competitive age-division athletes. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

6 Touko 201350min

#42: Alderspring's Glenn Elzinga, Grass-Fed Beef and a Bulletproof Protein

#42: Alderspring's Glenn Elzinga, Grass-Fed Beef and a Bulletproof Protein

With training in forestry and forest ecology, Glenn Elzinga began his forestry career in Maine. In the mid 1980s, he moved to Salmon, Idaho where he worked as District Forester for the Salmon BLM for over a decade. As his family began to grow, he realized he wanted a better way to raise kids than leaving them for work all day. So began his current career in ranching. After ranching for 17 years, Glenn's cattle herd has grown from 7 head to over 600. He keeps his hand in forestry by working with his wife, Caryl, on consulting projects and by horse-logging occasionally with his two Belgian mares, Pet and Pat. He hopes to train his new draft Suffolk geldings, Red and Snap, to log as well. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

2 Touko 201350min

#41: Jason Nunnelley, Self Tracking

#41: Jason Nunnelley, Self Tracking

Jason Nunnelley’s work is focused on application and systems development. After his first company sold in 2000, he spent his time helping small business capitalize on Internet technologies. He is presently dedicated to dosIQ, Inc., a Wellness Journal and set of apps designed to make self-tracking and health monitoring simple for anyone. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

22 Huhti 201358min

#40: Dan John, Brains & Brawn

#40: Dan John, Brains & Brawn

Dan John has spent his life with one foot in the world of lifting and throwing, and the other foot in academia. An All-American discus thrower, Dan has also competed at the highest levels of Olympic lifting, Highland Games and the Weight Pentathlon, an event in which he holds the American record. Dan spends his work life blending weekly workshops and lectures with full-time writing, and is also an online religious studies instructor for Columbia College of Missouri. As a Fulbright Scholar, he toured the Middle East exploring the foundations of religious education systems. His books, on weightlifting, include Intervention, Never Let Go, Mass Made Simple and Easy Strength, written with Pavel Tsatsouline as well as From Dad, To Grad. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

27 Maalis 201358min

#39: Hormone Alchemy (+ Why Hard Data is HOT)... How to Amplify the Positive Neuro-hormonal Dashboard with Dr. Sara Gottfried MD

#39: Hormone Alchemy (+ Why Hard Data is HOT)... How to Amplify the Positive Neuro-hormonal Dashboard with Dr. Sara Gottfried MD

Dr. Sara Gottfried is a Harvard doc, biohacker, and yoga-powered champion of your health, happiness and hormonal equilibrium. She’s also seen 20,000 patients in the past 20 years and applied her training as a MIT bioengineer to how women and men can leverage the upstream and downstream mediators to create natural hormone balance with next gen medicine, and wrote a book about it, called The Hormone Cure: Reclaim Balance, Sleep, Sex Drive, and Vitality Naturally with The Gottfried Protocol (Simon & Schuster, 3/12/13) She biohacked her own happy hormones and happy brain chemicals as a 30-something stress case battling McMedicine, PMS, and low sex drive. She was offered Prozac and a birth control pill for her misery by her primary care physician, and that was a defining moment that allowed her to step from her darkest hour into the grace of biohacking bliss. The main culprit: CORTISOL. It took her 4 weeks to get her crazy-high cortisol down to the Goldilocks position of not too high and not too low, and she applied that learning and refined her protocol on her next 10,000 patients over the next 10 years. Results were staggering: Dr. Sara could neutralize cortisol, what she calls the “bad-boyfriend” hormone in 1 minute. She reversed insulin resistance in 48 hours. She got estrogen back into it’s rightful place, and thyroid, inside of 2 weeks. She believes knowledge is power, science is sexy... and, oh yes, actionable needle-moving solutions are hot. Listen in for our dialogue about cutting-edge science, and crazy-lovin’ solutions -- for men and women. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

11 Maalis 20131h 4min

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