How Biohackers Use Nicotine WITHOUT Getting Addicted  : 1350

How Biohackers Use Nicotine WITHOUT Getting Addicted : 1350

This is Part 2 of the Nicotine Masterclass. If you haven’t heard Part 1, start there for a full breakdown of nicotine’s mechanisms, myths, and the science behind its misunderstood role in longevity, nootropics, and human performance.


Nicotine is one of the most misunderstood nootropics in the world—and one of the most powerful tools for brain optimization and longevity when used correctly. In this episode, Host Dave Asprey breaks down how to harness nicotine for cognitive enhancement, metabolism, and human performance without falling into addiction. You’ll learn the real science behind dosage, timing, and cycling, plus how nicotine interacts with mitochondria, acetylcholine, and neuroplasticity to boost focus, motivation, and mental energy.


Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR


This is Part 2 of the Nicotine Masterclass. If you haven’t heard Part 1, start there for a full breakdown of nicotine’s mechanisms, myths, and the science behind its misunderstood role in longevity, nootropics, and human performance.


Host Dave Asprey reveals practical biohacking templates for using nicotine safely and effectively—covering metabolism genetics, stack combinations, and how nicotine fits into a smarter not harder lifestyle. You’ll discover how low-dose nicotine can support attention, memory, and even protect against neurodegenerative diseases like Alzheimer’s and Parkinson’s. Dave also shares his own five-year nicotine protocol, how he avoided dependence, and why nicotine can be a game-changer for brain and mitochondrial performance when used intelligently.


You’ll Learn:

• How to use nicotine as a safe, powerful nootropic for brain optimization and focus

• The genetics of nicotine metabolism and why dose timing matters

• How to stack nicotine with caffeine, theanine, and rhodiola for maximum energy and motivation

• Why nicotine enhances mitochondria and PGC-1α for better metabolism and longevity

• The truth about nicotine tolerance, cycling, and how to avoid addiction

• How nicotine affects sleep, neuroplasticity, and dopamine signaling

• What science says about nicotine’s protective effects against Alzheimer’s and Parkinson’s

• How to integrate nicotine into a complete biohacking protocol with fasting, ketosis, and supplements


This episode is essential for anyone exploring biohacking, functional medicine, fasting, ketosis, sleep optimization, and cognitive resilience. You’ll learn how nicotine stacks with caffeine, theanine, rhodiola, and supplements for sharper thinking and sustained focus—plus the key mistakes to avoid so you don’t wreck your sleep or metabolism. Whether you’re a seasoned biohacker or just beginning your journey, this episode gives you the science, tools, and protocols to elevate your mind and body safely.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.


New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: nicotine biohacking, nicotine masterclass, Dave Asprey nicotine, nicotine nootropics, nicotine cognitive enhancement, nicotine mitochondria, nicotine and dopamine, nicotine addiction prevention, nicotine cycling, nicotine dosage, nicotine metabolism, nicotine tolerance, nicotine and longevity, nicotine patch benefits, nicotine for focus, nicotine and acetylcholine, nicotine and caffeine stack, nicotine sleep effects, nicotine and Parkinson’s, nicotine brain optimization


** Listen to part 1 here: https://www.youtube.com/watch?v=WjehLsHaRnE&t=1063s**


Thank you to our sponsors!

-GOT MOLD? | Go to http://gotmold.com/shop and use DAVE10 to save 10% and see what’s in your air.

-Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/dave.

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-MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order.


Resources:

• Danger Coffee: https://dangercoffee.com/discount/dave15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

00:00 – Trailer

01:25 – Review of Pt 1

02:48 – Genetics & Metabolism

06:05 – Stacking with Other Compounds

09:23 – Tolerance & Dependence

13:42 – Fertility & Contraindications

17:05 – Real World Use Templates

21:40 – Travel & Jet Lag Protocol

24:29 – Biohacking Lifestyle Integration

25:31 – Longevity & Neuroprotection

28:24 – Medical Applications & Research

31:51 – Final Thoughts & Summary

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Jaksot(1417)

#57 Becoming Alpha, Dispelling Myths & Making Changes, with Adam Bornstein

#57 Becoming Alpha, Dispelling Myths & Making Changes, with Adam Bornstein

As a top health and fitness editor and best-selling author, Adam Bornstein came on the show to share what it means to be ‘Alpha’ and how being bulletproof is possible for everyone. In this episode, Adam and I discuss our shared egg obsession, whether cheat days are helpful or harmful, and how mental barriers keep you from achieving the best version of yourself. You will even get a glimpse into the workings of mainstream media, research, and health journalism. Adam Bornstein is a biohacking, solutions oriented machine! Adam has been named “one of the most influential people in health.” He’s a long time health and fitness writer and editor for magazines like Men’s Health and Livestrong, and best-selling author of four fitness books, including his most recent book “Man 2.0 Engineering the Alpha: A Real World Guide to an Unreal Life: Build More Muscle. Burn More Fat. Have More Sex” See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

20 Elo 201354min

#56 Biohacking Apocalypse Survival, Stress Inoculation & Shamans, with Sam Sheridan

#56 Biohacking Apocalypse Survival, Stress Inoculation & Shamans, with Sam Sheridan

In an apocalypse, how would you biohack your survival? This episode dives into answering this question and discusses all things stress-related. It was a blast having Sam Sheridan, best selling author of The Disaster Diaries: How I Learned to Stop Worrying and Love the Apocalypse, on the show to talk about a wide variety of topics ranging from endurance vs. interval training to Cooper’s Color Code and shamans. You’ll hear about the science and psychology of stress, the best way to handle stress, and how to better your chances of surviving an apocalypse. Sam Sheridan was an amateur MMA fighter, EMT, wild-land fire fighter, cowboy, sailor and worked construction at the South Pole. He is also the best selling author of A Fighters Heart: One Man’s Journey Through the World of Fighting, he Fighters Mind: Inside the Mental Game. During research for his latest book The Disaster Diaries: Sam immerses himself in the survivalist and dooms-day preparation subculture by:  Attending stunt driving school;  Learning the art of eskrima (Filipino knife fighting); Participating in Cody Lundin’s (Dual Survival on Discovery Channel) Aboriginal Living Skills School; Learning how to steal a car with ex-gang bangers in Los Angeles. A large portion of The Disaster Diaries explains the bio-chemical cocktail that our bodies produce during moments of intense stress (i.e.  an apocalypse.)  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

13 Elo 201350min

#55 Fitness, Nutrition & Bulletproof Habits, with High Performance Health Coach, Yuri Elkaim

#55 Fitness, Nutrition & Bulletproof Habits, with High Performance Health Coach, Yuri Elkaim

From professional athlete to high performance health coach, Yuri Elkaim joins us today to talk about (almost) all things Bulletproof. In his goal to help 10,000,000 people become healthier, Yuri will share his take on raw food, the “fruit & veg” argument, exercise vs. rest, habits, and more! If you are an athlete (or biohacker) looking for 1 or 2 tips to take your performance to the next level, this is the show for you. Yuri Elkaim is a registered holistic nutritionist, fitness expert, and highly sought after high performance health coach. He’s also a former professional soccer player and served as the Head Strength & Conditioning and Nutrition Coach for men’s soccer at the University of Toronto for 7 seasons. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

9 Elo 201346min

#54 Neurofeedback Technology, Best Biohack Yet, with Dr. Valdeane Brown

#54 Neurofeedback Technology, Best Biohack Yet, with Dr. Valdeane Brown

This episode is all about the most effective biohack I’ve experience yet – NeurOptimal® brain training. Dr. Valdeane Brown, Founder of NeurOptimal, came on the show to explain how this technology takes your performance to uncharted levels! The NeurOptimal brain trainer is the most powerful and affordable neurofeedback technology available. You will get to hear about the EEG technology and how it transforms your brain, upgrade athletic performance, and even help with migraines, PTSD, and abusive relationships. Does this sound too good to be true? Listen for yourself… Dr. Valdeane W. Brown is an internationally recognized "trainer of neurofeedback trainers", who has taught and consulted widely on personal and organizational transformation. With a Ph.D. in Clinical Psychology and a background in math, physics, computer programming, philosophy, yoga, meditation and martial arts, Dr. Brown brings a presence and precision to his work. This is further informed by a profound sense of compassion, a facility with energy dynamics and a deep commitment to revealing the elegant simplicity inherent in learning and transformation. Developer of the Five Phase Model and co-creator with his wife Sue of the Period 3 Approach to Clinical Neurofeedback, Dr. Brown has realized his vision of a truly comprehensive training system in NeurOptimal. His vision in bringing NeurOptimal to the world is to make personal transformation effortless and available to all. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

6 Elo 20131h 1min

#53 Raw Vegan to Bulletproof Meat Eater - a beneficial transformation, with Kristen 'Raw' Suzanne

#53 Raw Vegan to Bulletproof Meat Eater - a beneficial transformation, with Kristen 'Raw' Suzanne

This episode brings to light an ex-vegan advocate’s journey to eating a mostly meat-embraced Bulletproof diet. Kristen ‘Raw’ Suzanne, author, popular blogger, and nutrition researcher, shared her former vegan assumptions, how easy or difficult it was to change, and the ethics of food. We also dove into a detailed conversations about liver meat, fertility issues on a vegan diet, how to stay Bulletproof when traveling with family, and how to nourish your kids the best way possible. In 2005, Kristen walked away from her corporate career in executive-level operations to focus on her true passion: healthy food. Already a vegan for two years, she turned her attention to the raw vegan cuisine and lifestyle, initially teaching classes and providing personal chef services, but as her online audience grew, she ultimately shifted to full-time blogging, recipe development, and eventually publishing 12 books on raw vegan diets. By 2012, concerns with her and her child's health forced her to reevaluate the nutritional claims made by advocates of raw and vegan diets. After Kristen introduced high quality animal products into her family's diet, she saw dramatic improvements almost immediately. Her family now eats a diet high in grass-fed beef and butter, bison, pastured eggs, and wild-caught seafood, while avoiding grains, gluten, and soy. While her personal transformation and conversion from vegan to omnivore has been controversial in the vegan and raw food community, Kristen has been on hiatus from blogging to spend time researching and fully exploring the nutritional and culinary aspects of eating in this new way for her family. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

1 Elo 201357min

#52 – Sex, Sex Culture & Sex at Dawn with Christopher Ryan - Podcast

#52 – Sex, Sex Culture & Sex at Dawn with Christopher Ryan - Podcast

Welcome to our first ever VIDEO and audio podcast, where we’re celebrating by exploring everyone’s favorite topic – sex! This episode, with co-author of New York Times best seller, Sex at Dawn: How We Mate, Why We Stray, and What it Means for Modern Relationships, Christopher Ryan, gives you a peak into the evolutionary view of human sexual behavior. Sex at Dawn shatters myths surrounding the societal history behind how men and women interact in sexual relationships. Christopher made for a great interview, as he continues to rustle feathers around the ideas of traditional relationships.  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

26 Heinä 201353min

#51 Transhumanism, Technology & the Future with Natasha Vita-More

#51 Transhumanism, Technology & the Future with Natasha Vita-More

This episode stretches the boundaries of biohacking by looking at the futurist ideology and movement called transhumanism. Natasha Vita-More, an American designer, theorist and author, joined me on this episode to discuss the possible transformation of the human condition by developing technologies that enhance intellectual, physical, and psychological capacities.  Natasha Vita-more is co-editor and author of The Transhumanist Reader: Classical and Contemporary Essays on the Science, Technology and Philosophy of the Human Future and designer and author of "Primo Posthuman," a pioneering future whole body prototype. Vita-More is a professor at the University of Advancing Technology, and a Fellow of the Institute for Ethics and Emerging Technologies and the Hybrid Reality Institute. She is currently Chairman of the Board of Directors of Humanity+. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

23 Heinä 201349min

#50 New Bulletproof iPhone App, Food Sensitivities & HRV with Ronda Collier from SweetWater Health

#50 New Bulletproof iPhone App, Food Sensitivities & HRV with Ronda Collier from SweetWater Health

The 50th episode of Bulletproof Executive Radio introduces you to a brand new free iPhone app called Bulletproof(R) Food Sense and to the scientist who made it all happen.  Today’s interview is with long time biohacker and founder of Sweetwater Health™, Ronda Collier. Ronda is putting her more than 25 years of experience in high tech to work at SweetWater Health™, where they are looking at the signal coming from the human heart, and instead of seeing beats per minute or simple heart rate variability, seeing a huge pool of big data just waiting to be analyzed using Ronda’s crazy advanced math skills. There is a lot more information in your heartbeat than you’d think – stress levels are just the beginning. By applying mobile health monitoring and stress management with medical research techniques, SweetWater Health is creating some very advanced, very easy to use biohacking technologies. My experience as a bio hacker who used to weigh 300 pounds and really struggled with food cravings, is that every single person has a set of things in their environment or their food that makes them weak. SweetWater Health and Bulletproof Executive just partnered to create the free Bulletproof(R) Food Sense iPhone app to help you find your personal kryptonite by using the phone’s onboard sensors to detect your hidden food sensitivities.   You can also get an amazingly full-featured version of the app that works with a chest strap to measure and track your heart rate variability all day long and use complex algorithms to quantify your food, stress, and overall health. Click here to download your free Bulletproof Food Sense app from the Apple iTunes store. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

16 Heinä 201348min

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