How Biohackers Use Nicotine WITHOUT Getting Addicted  : 1350

How Biohackers Use Nicotine WITHOUT Getting Addicted : 1350

This is Part 2 of the Nicotine Masterclass. If you haven’t heard Part 1, start there for a full breakdown of nicotine’s mechanisms, myths, and the science behind its misunderstood role in longevity, nootropics, and human performance.


Nicotine is one of the most misunderstood nootropics in the world—and one of the most powerful tools for brain optimization and longevity when used correctly. In this episode, Host Dave Asprey breaks down how to harness nicotine for cognitive enhancement, metabolism, and human performance without falling into addiction. You’ll learn the real science behind dosage, timing, and cycling, plus how nicotine interacts with mitochondria, acetylcholine, and neuroplasticity to boost focus, motivation, and mental energy.


Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR


This is Part 2 of the Nicotine Masterclass. If you haven’t heard Part 1, start there for a full breakdown of nicotine’s mechanisms, myths, and the science behind its misunderstood role in longevity, nootropics, and human performance.


Host Dave Asprey reveals practical biohacking templates for using nicotine safely and effectively—covering metabolism genetics, stack combinations, and how nicotine fits into a smarter not harder lifestyle. You’ll discover how low-dose nicotine can support attention, memory, and even protect against neurodegenerative diseases like Alzheimer’s and Parkinson’s. Dave also shares his own five-year nicotine protocol, how he avoided dependence, and why nicotine can be a game-changer for brain and mitochondrial performance when used intelligently.


You’ll Learn:

• How to use nicotine as a safe, powerful nootropic for brain optimization and focus

• The genetics of nicotine metabolism and why dose timing matters

• How to stack nicotine with caffeine, theanine, and rhodiola for maximum energy and motivation

• Why nicotine enhances mitochondria and PGC-1α for better metabolism and longevity

• The truth about nicotine tolerance, cycling, and how to avoid addiction

• How nicotine affects sleep, neuroplasticity, and dopamine signaling

• What science says about nicotine’s protective effects against Alzheimer’s and Parkinson’s

• How to integrate nicotine into a complete biohacking protocol with fasting, ketosis, and supplements


This episode is essential for anyone exploring biohacking, functional medicine, fasting, ketosis, sleep optimization, and cognitive resilience. You’ll learn how nicotine stacks with caffeine, theanine, rhodiola, and supplements for sharper thinking and sustained focus—plus the key mistakes to avoid so you don’t wreck your sleep or metabolism. Whether you’re a seasoned biohacker or just beginning your journey, this episode gives you the science, tools, and protocols to elevate your mind and body safely.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.


New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: nicotine biohacking, nicotine masterclass, Dave Asprey nicotine, nicotine nootropics, nicotine cognitive enhancement, nicotine mitochondria, nicotine and dopamine, nicotine addiction prevention, nicotine cycling, nicotine dosage, nicotine metabolism, nicotine tolerance, nicotine and longevity, nicotine patch benefits, nicotine for focus, nicotine and acetylcholine, nicotine and caffeine stack, nicotine sleep effects, nicotine and Parkinson’s, nicotine brain optimization


** Listen to part 1 here: https://www.youtube.com/watch?v=WjehLsHaRnE&t=1063s**


Thank you to our sponsors!

-GOT MOLD? | Go to http://gotmold.com/shop and use DAVE10 to save 10% and see what’s in your air.

-Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/dave.

-ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order.

-MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order.


Resources:

• Danger Coffee: https://dangercoffee.com/discount/dave15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

00:00 – Trailer

01:25 – Review of Pt 1

02:48 – Genetics & Metabolism

06:05 – Stacking with Other Compounds

09:23 – Tolerance & Dependence

13:42 – Fertility & Contraindications

17:05 – Real World Use Templates

21:40 – Travel & Jet Lag Protocol

24:29 – Biohacking Lifestyle Integration

25:31 – Longevity & Neuroprotection

28:24 – Medical Applications & Research

31:51 – Final Thoughts & Summary

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Jaksot(1413)

#45: Q & A More on Coffee, Kale, & Adrenal Fatigue

#45: Q & A More on Coffee, Kale, & Adrenal Fatigue

Questions Asked in the Podcast:   1:20 What is the best way to store Bulletproof Coffee and can you pre-grind it and store it? 4:10 For people who like to do heavy workouts several times a week what do you recommend for  recovery and muscle building? 5:30 What's the deal with drugs, specifically marijuana? Is it Bulletproof? 7:14 What about marijuana by products like Hemp protein powder or Hemp seed oil? 8:44 How can I get a Bulletproof T-shirt like the one Dave had on the Joe Rogan Experience? (bulletproofexec.com/shirts) 10:01 What are the differences between the new Bulletproof Upgraded Brain Octane Oil and the Bulletproof MCT Oil? Does the Octane Oil replace the MCT Oil or is it mean to be an addition? 13:10 Can I add the Upgraded Whey into my coffee without pushing myself out of ketogenesis? 14:28 Why is there no Certified Organic label on the MCT Oil? 15:10 How do you make a proper iced ,and blended iced, Bulletproof coffee without the fat sticking to the sides or globbing together? 16:22 Is taking Bioidentical growth hormone safe? 17:34 In the Kale Shake you list raw eggs as a potential addition, would eggshells work as well? 18:49 I massage my kale before blending or sauteing it, do I still need to stew this before steaming, or should I just cut the massage out altogether? Also are the oxalates in baby kale less? 19:43 Should I make a kale shake in addition to or in lieu of Bulletproof coffee? 20:35 Are kale chips Bulletproof? 22:19 Why is Bulletproof Coffee NOT affected by the coffee fungus problem? 24:21 Changing your diet making you stinky? 26:40 Activated charcoal and its benefits 30:24 How do I recover if I have a cheat meal from the Bulletproof Diet? 32:03 How to schedule Bulletproof Coffee and Diet around a crazy sleep schedule 35:30 Can I substitute kale with broccoli to avoid the toxins? 35:50 Adrenal Fatigue, how do you know you have it, what are some common causes, and how do I make it better? 39:35 How do you gain weight while Bulletproof? 42:35 Biohacks of the week and other conversation...   See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

10 Kesä 201349min

Bonus: Client Review with Jonathan Kos

Bonus: Client Review with Jonathan Kos

Jonathan Kos is an IT professional and a recent follower of the Bulletproof Diet.  He is a 44 year old IT professional . At 6' 3" and a former college athlete that played football, competitive ice hockey up until the age of 25 he was an extremely fit 220 lbs and my coaches wanted me up to 275 or so to play the defensive line so I was eating literally non stop to put weight on. After college he dropped down to around 200 lbs and eventually settled at for me was a healthy 235.  As he got older and more settled in his job, his weight climbed and he couldn’t keep his weight in check with exercise alone and he started to have to diet he was up to 300 lbs and was exercising more that ever but the weight didn’t come off. After he met his wife, exercise was out the window, a carb heavy diet was in, and his weight ballooned up to 365lbs. He was about to give up until he heard Tait Fletcher on Joe Rogan's podcast mentioning Bulletproof ® Coffee and he gave it a shot. He lost 45lbs in 45 days, and is here to share his experience with you.  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Kesä 201311min

#44: Salt and self-experimentation with Greg Pomerantz

#44: Salt and self-experimentation with Greg Pomerantz

For Greg Pomerantz everything is a science experiment. He takes citizen science to a personal level by biohacking his blood pressure and detailing his data. He blogged about his self-experiment research on salt clarifying some concerns he had about salt’s effect on the body. He determined what his salt type is, either one is salt sensitive, or one that isn’t affected much by increases in salt. He discusses how to do that in today’s podcast. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Kesä 201337min

#43: Kelly Starrett, Mobility and Performance

#43: Kelly Starrett, Mobility and Performance

Coach Kelly Starrett received his Doctor of Physical Therapy in 2007 from Samuel Merritt College in Oakland, California. He currently runs his own physical therapy practice at San Francisco CrossFit—one of the first 50 CrossFit affiliates—and focuses on performance-based Orthopedic Sports Medicine with an emphasis on returning athletes to elite level sport and performance. His clients see exceptional results from his progressive blend of manual physical therapy and strength training. Since 2009, Kelly has been traveling the country teaching his "Movement, Mobility & Maintenance Course" in an effort to spread his message that good mobility and proper movement are the keys to good performance and that all humans should be able to perform this basic maintenance on themselves. Kelly's clients have included Olympic gold-medalists, Tour de France cyclists, world-class extreme skiers and X-Games medalists, dancers with Smuin, San Francisco, and Sacramento Ballet Companies, military personnel, and competitive age-division athletes. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

6 Touko 201350min

#42: Alderspring's Glenn Elzinga, Grass-Fed Beef and a Bulletproof Protein

#42: Alderspring's Glenn Elzinga, Grass-Fed Beef and a Bulletproof Protein

With training in forestry and forest ecology, Glenn Elzinga began his forestry career in Maine. In the mid 1980s, he moved to Salmon, Idaho where he worked as District Forester for the Salmon BLM for over a decade. As his family began to grow, he realized he wanted a better way to raise kids than leaving them for work all day. So began his current career in ranching. After ranching for 17 years, Glenn's cattle herd has grown from 7 head to over 600. He keeps his hand in forestry by working with his wife, Caryl, on consulting projects and by horse-logging occasionally with his two Belgian mares, Pet and Pat. He hopes to train his new draft Suffolk geldings, Red and Snap, to log as well. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

2 Touko 201350min

#41: Jason Nunnelley, Self Tracking

#41: Jason Nunnelley, Self Tracking

Jason Nunnelley’s work is focused on application and systems development. After his first company sold in 2000, he spent his time helping small business capitalize on Internet technologies. He is presently dedicated to dosIQ, Inc., a Wellness Journal and set of apps designed to make self-tracking and health monitoring simple for anyone. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

22 Huhti 201358min

#40: Dan John, Brains & Brawn

#40: Dan John, Brains & Brawn

Dan John has spent his life with one foot in the world of lifting and throwing, and the other foot in academia. An All-American discus thrower, Dan has also competed at the highest levels of Olympic lifting, Highland Games and the Weight Pentathlon, an event in which he holds the American record. Dan spends his work life blending weekly workshops and lectures with full-time writing, and is also an online religious studies instructor for Columbia College of Missouri. As a Fulbright Scholar, he toured the Middle East exploring the foundations of religious education systems. His books, on weightlifting, include Intervention, Never Let Go, Mass Made Simple and Easy Strength, written with Pavel Tsatsouline as well as From Dad, To Grad. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

27 Maalis 201358min

#39: Hormone Alchemy (+ Why Hard Data is HOT)... How to Amplify the Positive Neuro-hormonal Dashboard with Dr. Sara Gottfried MD

#39: Hormone Alchemy (+ Why Hard Data is HOT)... How to Amplify the Positive Neuro-hormonal Dashboard with Dr. Sara Gottfried MD

Dr. Sara Gottfried is a Harvard doc, biohacker, and yoga-powered champion of your health, happiness and hormonal equilibrium. She’s also seen 20,000 patients in the past 20 years and applied her training as a MIT bioengineer to how women and men can leverage the upstream and downstream mediators to create natural hormone balance with next gen medicine, and wrote a book about it, called The Hormone Cure: Reclaim Balance, Sleep, Sex Drive, and Vitality Naturally with The Gottfried Protocol (Simon & Schuster, 3/12/13) She biohacked her own happy hormones and happy brain chemicals as a 30-something stress case battling McMedicine, PMS, and low sex drive. She was offered Prozac and a birth control pill for her misery by her primary care physician, and that was a defining moment that allowed her to step from her darkest hour into the grace of biohacking bliss. The main culprit: CORTISOL. It took her 4 weeks to get her crazy-high cortisol down to the Goldilocks position of not too high and not too low, and she applied that learning and refined her protocol on her next 10,000 patients over the next 10 years. Results were staggering: Dr. Sara could neutralize cortisol, what she calls the “bad-boyfriend” hormone in 1 minute. She reversed insulin resistance in 48 hours. She got estrogen back into it’s rightful place, and thyroid, inside of 2 weeks. She believes knowledge is power, science is sexy... and, oh yes, actionable needle-moving solutions are hot. Listen in for our dialogue about cutting-edge science, and crazy-lovin’ solutions -- for men and women. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

11 Maalis 20131h 4min

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