64. The Truth About Weight Gain, Menopause, and “Weight Loss Drugs” — with Dr. Sasha High

64. The Truth About Weight Gain, Menopause, and “Weight Loss Drugs” — with Dr. Sasha High

If you’ve ever wondered why your body seems to be changing through midlife — even when your habits haven’t — this episode is a must-listen.

Melissa sits down once again with Dr. Sasha High (@sashahighmd), obesity physician and leading voice in metabolic health, for an eye-opening conversation about weight gain and weight loss during the menopause transition.

Dr. High breaks down the latest science behind today’s most talked-about obesity medications — and why calling them “weight loss drugs” is not only misleading, but potentially dangerous. She explains who these medications are really for, who shouldn’t be taking them, and why trendy “microdosing” approaches can backfire in serious ways.

If you’ve struggled with midlife weight changes, felt confused by conflicting advice, or just want the truth — free of diet fads and fear — Dr. High’s compassionate, evidence-based approach will change the way you think about your body, your metabolism, and your health.

In this episode:



  • Why weight gain during menopause is normal — and what’s really behind it
  • The science (and myths) of new obesity treatment medications
  • Why “weight loss drug” culture is dangerous and inaccurate
  • The truth about “microdosing” and other social media fads
  • How Dr. High helps menopausal women find real, sustainable, science-backed solutions

Listen now — and start aging powerfully, inside and out.

This episode is supported by Aging Powerfully with Melissa Grelo: The Retreat and partners @GoodLifeFitness, @lovemy.iris, @avene and @rexalldrugstoreofficial.

Tech and Audio Producer: Drew Garner

Producer: Melissa Grelo

For any partnership inquires, contact beverly@agingpowerfullywithmelissagrelo.com

Jaksot(79)

74. From Lab to Life (Part 2): What You Need To Know About Cancer Diagnoses, Research and Care in Canada With Dr. Lillian Siu & Dr. Miyo Yamashita

74. From Lab to Life (Part 2): What You Need To Know About Cancer Diagnoses, Research and Care in Canada With Dr. Lillian Siu & Dr. Miyo Yamashita

Cancer is one of the most frightening diagnoses any of us can face — and yet, it’s also an area of medicine where progress is happening at an extraordinary pace.In honour of World Cancer Day, this epi...

5 Helmi 34min

74. From Lab to Life (Part 1): What You Need To Know About Cancer Diagnoses, Research and Care in Canada With Dr. Lillian Siu & Dr. Miyo Yamashita

74. From Lab to Life (Part 1): What You Need To Know About Cancer Diagnoses, Research and Care in Canada With Dr. Lillian Siu & Dr. Miyo Yamashita

Cancer is one of the most frightening diagnoses any of us can face — and yet, it’s also an area of medicine where progress is happening at an extraordinary pace. In honour of World Cancer Day, this ep...

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73. A Very Special Episode: My Parents on Shingles, Resilience, and Health in Their 80s

73. A Very Special Episode: My Parents on Shingles, Resilience, and Health in Their 80s

In this very special and personal episode of Aging Powerfully with Melissa Grelo, I’m joined by my parents, Claire and Frank Grelo, to talk about something I never expected to experience so close to h...

29 Tammi 32min

72. Jann Arden on Dementia, Alzheimer’s & Love in the Long Goodbye

72. Jann Arden on Dementia, Alzheimer’s & Love in the Long Goodbye

In this deeply personal episode of Aging Powerfully, I sit down with Jann Arden to talk about her family’s journey through dementia and Alzheimer’s disease — with both of her parents. Jann shares the ...

22 Tammi 54min

71. Oscar Winner Marcia Gay Harden on Alzheimer’s, Grief & the Love That Never Leaves

71. Oscar Winner Marcia Gay Harden on Alzheimer’s, Grief & the Love That Never Leaves

Academy Award–winning actress Marcia Gay Harden joins me on Aging Powerfully with Melissa Grelo for an intimate conversation about losing her mother to Alzheimer’s — and what it taught her about love,...

15 Tammi 17min

70. Alzheimer’s, the Menopausal Brain & Closing the Gender Gap in Science with Dr. Liisa Galea

70. Alzheimer’s, the Menopausal Brain & Closing the Gender Gap in Science with Dr. Liisa Galea

January is Alzheimer’s Awareness Month in Canada, and this episode tackles a critical — and often overlooked — reality: nearly two-thirds of Alzheimer’s diagnoses are in women.Melissa is joined by ret...

8 Tammi 1h

69. 2025 POWER (RE)PLAY + A Look Ahead to 2026

69. 2025 POWER (RE)PLAY + A Look Ahead to 2026

2025 was one of my busiest—and most meaningful—years yet. Thank you for being on this journey with me and for showing up week after week to learn, question, laugh, and age powerfully together.As we wr...

18 Joulu 202533min

POWER (RE)PLAY - Episode 13 - Hair Loss, Hormones & Hope with Dr. Renée A. Beach (originally aired March 28, 2024)

POWER (RE)PLAY - Episode 13 - Hair Loss, Hormones & Hope with Dr. Renée A. Beach (originally aired March 28, 2024)

In this episode of Aging Powerfully, Melissa digs into one of the most emotional (and common!) midlife topics: hair loss, with medical and cosmetic dermatologist, Dr. Renée A. Beach (@dermabeach). Fro...

11 Joulu 202547min

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