10-Minute Biohacking News Update : 1367

10-Minute Biohacking News Update : 1367

This episode covers:


Nano CBD Pain Relief Without Cognitive Side Effects


A new nano-micelle formulation of CBD called CBD-IN delivers fast, non-addictive pain relief in mice without memory issues, motor impairment or the usual cannabinoid “fog.” Because it crosses the blood brain barrier and directly targets hyperactive pain circuits, it sidesteps many opioid-type drawbacks. Dave explains why precision-designed cannabinoids could reshape chronic pain treatment and longevity support.

Source: https://www.sciencedaily.com/releases/2025/11/251117095652.htm



Moderate Calorie Restriction Slows Biological Aging


A long-term trial from the National Institute on Aging found that cutting calories by about 12% over two years slowed the pace of aging — measured by methylation clocks and metabolic markers — in lean and mildly overweight adults alike. Dave breaks down why small, manageable dietary tweaks can deliver big longevity gains, without crash dieting or extreme fasting.

Source: https://www.nia.nih.gov/news/cutting-calories-may-slow-pace-aging-healthy-adults


FDA Approves AI-Guided Robotic Surgery Trials for Alzheimer’s


The U.S. Food and Drug Administration (FDA) has granted IDE approval for the first robotic microsurgical study targeting early stage Alzheimer’s disease using AI and deep imaging. The trial uses adaptive robotics to target deep brain lymphatic pathways, potentially clearing amyloid/tau deposits with surgical precision. Dave explains why this signals a new era in neurodegeneration – moving from drug-only to machine-assisted brain repair.

Source: https://www.mmimicro.com/ide-approval-for-first-robotic-microsurgery-alzheimers-study/


Antibiotic Reprograms Gut Bacteria to Produce Anti-Aging Molecules


Researchers demonstrated that the veterinary antibiotic cephaloridine can reprogram gut microbes to secrete colanic acid — a molecule linked to better mitochondrial health, reduced gut permeability and improved cholesterol/insulin balance in mice. Dave explores how this could evolve into a pipeline of engineered probiotics that act as internal “longevity factories.”

Source: https://newatlas.com/aging/antibiotic-longevity-microbiome/ (link remains unchanged)


Klotho: The Longevity Protein Nears Clinical Reality


The longevity protein Klotho, known for clearing toxic by-products, calming inflammation and protecting brain/organ networks, is now advancing toward human trials via injectables, oral formats and gene therapy. Dave explains why Klotho is shaping up as a foundational target for next-gen age-reversal strategies and stacking protocols.

Source: https://investingnews.com/longevity-focused-health-fueling-u-s-anti-aging-products-market-projected-to-reach-27-billion-by-2033/ (link remains unchanged)


All source links provided for easy reference to the original reporting and research above.


This episode is essential listening for fans of biohacking, human performance, functional medicine and longevity who want practical tools from Host ­Dave Asprey and the latest breakthroughs shaping the future of health.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade gives you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence and conscious living.


New episodes are released every Tuesday, Thursday, Friday (audio only) and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: nano CBD, CBD-IN, pain relief research, non opioid pain therapies, chronic pain and aging, caloric restriction aging, methylation clocks, metabolic resilience, AI robotics, Alzheimer’s microsurgery, neurotech advancement, microbiome engineering, colanic acid, longevity probiotics, mitochondrial support, Klotho protein, anti aging gene therapy, cellular rejuvenation, longevity news, biohacking updates


Thank you to our sponsors!



Resources:

• Subscribe to my weekly newsletter: https://substack.daveasprey.com/welcome

• Danger Coffee: https://dangercoffee.com/discount/dave15

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Intro

0:19 — Story 1: Nano CBD for Pain Relief

1:53 — Story 2: Caloric Restriction and Aging

3:20 — Story 3: AI Robotic Surgery for Alzheimer’s

4:50 — Story 4: Microbiome Reprogramming

6:05 — Substack Announcement

7:04 — Story 5: Klotho Longevity Protein

8:39 — Weekly Homework

9:31 — Outro

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Jaksot(1429)

Bulletproof Radio Q&A – Nicotine Benefits, Bulletproof Labs & Top Hacks - #236

Bulletproof Radio Q&A – Nicotine Benefits, Bulletproof Labs & Top Hacks - #236

On this episode of Bulletproof Radio, we have carefully selected the best questions from Facebook, Twitter, and the Bulletproof® Forums for another awesome Q&A. Join Dave and Zak as they answer questions about the benefits of nicotine on brain function and fat loss, getting the best source of caffeine from Yerba Mate or coffee, and bulletproof cooking along with other great questions that our listeners have submitted to Bulletproof Radio. This episode has a ton of great information all condensed into one, enjoy! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

17 Heinä 201554min

Dr. Ibrahim Karim: Harmony, Vitality & Biogeometry - #235

Dr. Ibrahim Karim: Harmony, Vitality & Biogeometry - #235

Dr. Ibrahim Karim comes on Bulletproof Radio today to discuss BioGeometry, creating and restoring harmony, hacking your space, and feng shui. Dr. Ibrahim Karim is an architect and the founder of BioGeometry, the science of using the energy principles of shape to balance biological energy systems and harmonize their interactions with the environment. He is the CEO, president and founder of BioGeometry Energy Systems LTD and the owner of Alemara Architecture Consultants, which was founded by his father in the 1930s. He is a graduate of the prestigious Federal Institute of Technology (ETH) in Zurich, Switzerland with MA and D.Sc. in Architecture and Tourist Planning. He occasionally teaches as a visiting professor of Architecture at several universities. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

14 Heinä 201546min

Steve Wood: Reduce High Blood Pressure & The Benefits of Isometric Exercise - #234

Steve Wood: Reduce High Blood Pressure & The Benefits of Isometric Exercise - #234

Steve Wood comes on Bulletproof Radio today to discuss reducing high blood pressure, the benefits of isometric exercise, and biohacking with Zona Plus. Steve Wood is the President and CEO of Zona Health which manufactures and sells the Zona Plus. With over 30 years of executive management experience, including 10 years in the medical device field, he has directed the marketing of medical devices in the US, EU and Canada increasing sales 8x in 3 years. He has a BA in Political Science and Economics from Pepperdine University and is a fellow of the International Academy of Apologetics in Strasbourg, France. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

10 Heinä 201557min

Emily Morse (Sex with Emily): Orgasms, Kegels & Sexology - #233

Emily Morse (Sex with Emily): Orgasms, Kegels & Sexology - #233

Emily Morse comes on Bulletproof Radio today to discuss improving your sex life, education around sex, premature ejaculation and overcoming it, and if size really matters. Emily Morse is a sex and relationship expert and host of the top downloaded podcast, Sex with Emily.   She is a Bravo TV star and author of Hot Sex: Over 200 Things You Can Try Tonight. Emily was voted the #1 dating and sex expert by DatingAdvice.com and the #1 dating and sex expert to follow on Twitter. She has been featured in The New York Times, Los Angeles Times and San Francisco Chronicle. Emily earned her Doctor of Human Sexuality from the Institute for the Advance Study of Human Sexuality. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

7 Heinä 201556min

Robert Mckee: Master the Art of Storytelling - #232

Robert Mckee: Master the Art of Storytelling - #232

Robert McKee comes on Bulletproof Radio today to discuss how storytelling can get you a job, how big companies use storytelling, creating a meaningful brand, and how you can improve your story.  Robert McKee, a Fulbright Scholar, is an author, BAFTA winner and the most sought after screenwriting lecturer on the planet. Former students of his “STORY Seminar” include over 60 Academy Award Winners, 200 Emmy Award Winners, 100 WGA Award Winners and 50 DGA Award Winners. Robert has been profiled on 60 Minutes and his articles on STORY have been featured in Harvard Business Review, The Wall Street Journal, Vanity Fair and many more. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Heinä 201556min

Dr. Julie Holland: Sex, Ecstasy & Antidepressants - #231

Dr. Julie Holland: Sex, Ecstasy & Antidepressants - #231

Dr. Julie Holland comes on Bulletproof Radio today to discuss hacking orgasms, medicinal ecstasy, getting off antidepressants, and why testosterone is important for women.  Julie Holland, M.D., is a psychiatrist who specializes in psychopharmacology. She is the author of Weekends at Bellevue and her new book, Moody Bitches: The Truth About the Drugs You’re Taking, the Sleep You’re Missing, and What’s Really Making You Feel Crazy. She is also the editor of two non-profit books on MDMA and Cannabis where the proceeds from each fund therapeutic studies. She has been featured on CNN, Katie Couric, Dr. Oz, Good Morning America, and Today. She has a private practice in New York City and lives with her husband and two children in Harlem Valley. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

30 Kesä 20151h 7min

Max Lugavere: Dementia, Aerobic Exercise & Filming Bread Head - #229

Max Lugavere: Dementia, Aerobic Exercise & Filming Bread Head - #229

Why you should listen –  Max Lugavere comes on Bulletproof Radio today to discuss his upcoming documentary Bread Head, preventing cognitive decline, early stages of Alzheimer’s and dementia, and the effects of gluten on our brains.  Enjoy the show! Max Lugavere is a multi-hyphenate filmmaker and media personality. He is the director, writer, and narrator of BREAD HEAD, a documentary exploring the impact of diet and lifestyle on brain health. Max has written about science, technology and health innovation for The Daily Beast, Fast Company, Huffington Post, and Psychology Today. Max created and hosted Acting Disruptive, AOL’s top viewed web series ever. He was also the host and producer of Al Gore’s Emmy-winning Current TV. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

23 Kesä 20151h 4min

Dr. Joseph Mercola: Roundup, Aspartame & Intermittent Fasting - #228

Dr. Joseph Mercola: Roundup, Aspartame & Intermittent Fasting - #228

Why you should listen –  Dr. Joseph Mercola comes on Bulletproof Radio today to discuss how sitting down harms us, why you should intermittently fast and, the truth about Aspartame and Roundup.   Dr. Mercola is a well-known osteopathic physician (DO) and a three-time New York Times Bestselling author. He is the founder of Mercola.com, which is the #1 Natural Health site on the Internet with over one million subscribers. Dr. Mercola was named the top Ultimate Wellness Game Changer by the Huffington Post in 2009. He has been featured in various media outlets such as TIME magazine, LA Times, ABC News, CNN, Fox News, Today Show, Dr. Oz, Forbes Magazine and others. His primary passion is transforming the conventional medical paradigm in the United States. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

17 Kesä 201558min

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