10-Minute Biohacking News Update : 1367

10-Minute Biohacking News Update : 1367

This episode covers:


Nano CBD Pain Relief Without Cognitive Side Effects


A new nano-micelle formulation of CBD called CBD-IN delivers fast, non-addictive pain relief in mice without memory issues, motor impairment or the usual cannabinoid “fog.” Because it crosses the blood brain barrier and directly targets hyperactive pain circuits, it sidesteps many opioid-type drawbacks. Dave explains why precision-designed cannabinoids could reshape chronic pain treatment and longevity support.

Source: https://www.sciencedaily.com/releases/2025/11/251117095652.htm



Moderate Calorie Restriction Slows Biological Aging


A long-term trial from the National Institute on Aging found that cutting calories by about 12% over two years slowed the pace of aging — measured by methylation clocks and metabolic markers — in lean and mildly overweight adults alike. Dave breaks down why small, manageable dietary tweaks can deliver big longevity gains, without crash dieting or extreme fasting.

Source: https://www.nia.nih.gov/news/cutting-calories-may-slow-pace-aging-healthy-adults


FDA Approves AI-Guided Robotic Surgery Trials for Alzheimer’s


The U.S. Food and Drug Administration (FDA) has granted IDE approval for the first robotic microsurgical study targeting early stage Alzheimer’s disease using AI and deep imaging. The trial uses adaptive robotics to target deep brain lymphatic pathways, potentially clearing amyloid/tau deposits with surgical precision. Dave explains why this signals a new era in neurodegeneration – moving from drug-only to machine-assisted brain repair.

Source: https://www.mmimicro.com/ide-approval-for-first-robotic-microsurgery-alzheimers-study/


Antibiotic Reprograms Gut Bacteria to Produce Anti-Aging Molecules


Researchers demonstrated that the veterinary antibiotic cephaloridine can reprogram gut microbes to secrete colanic acid — a molecule linked to better mitochondrial health, reduced gut permeability and improved cholesterol/insulin balance in mice. Dave explores how this could evolve into a pipeline of engineered probiotics that act as internal “longevity factories.”

Source: https://newatlas.com/aging/antibiotic-longevity-microbiome/ (link remains unchanged)


Klotho: The Longevity Protein Nears Clinical Reality


The longevity protein Klotho, known for clearing toxic by-products, calming inflammation and protecting brain/organ networks, is now advancing toward human trials via injectables, oral formats and gene therapy. Dave explains why Klotho is shaping up as a foundational target for next-gen age-reversal strategies and stacking protocols.

Source: https://investingnews.com/longevity-focused-health-fueling-u-s-anti-aging-products-market-projected-to-reach-27-billion-by-2033/ (link remains unchanged)


All source links provided for easy reference to the original reporting and research above.


This episode is essential listening for fans of biohacking, human performance, functional medicine and longevity who want practical tools from Host ­Dave Asprey and the latest breakthroughs shaping the future of health.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade gives you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence and conscious living.


New episodes are released every Tuesday, Thursday, Friday (audio only) and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: nano CBD, CBD-IN, pain relief research, non opioid pain therapies, chronic pain and aging, caloric restriction aging, methylation clocks, metabolic resilience, AI robotics, Alzheimer’s microsurgery, neurotech advancement, microbiome engineering, colanic acid, longevity probiotics, mitochondrial support, Klotho protein, anti aging gene therapy, cellular rejuvenation, longevity news, biohacking updates


Thank you to our sponsors!



Resources:

• Subscribe to my weekly newsletter: https://substack.daveasprey.com/welcome

• Danger Coffee: https://dangercoffee.com/discount/dave15

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Intro

0:19 — Story 1: Nano CBD for Pain Relief

1:53 — Story 2: Caloric Restriction and Aging

3:20 — Story 3: AI Robotic Surgery for Alzheimer’s

4:50 — Story 4: Microbiome Reprogramming

6:05 — Substack Announcement

7:04 — Story 5: Klotho Longevity Protein

8:39 — Weekly Homework

9:31 — Outro

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Jaksot(1423)

Podcast #8: Quantifying Recovery With RestWise

Podcast #8: Quantifying Recovery With RestWise

RestWise is the first software program that enables athletes to track their recovery.  This system is being used by everyone from the world’s top olympians to the weekend warriors.  Using science based metrics such as heart rate, blood oxygen saturation, mood, and sleep, RestWise gives athletes the ability to look at their recovery over time and make changes based on their results.  Jeff Hunt, the cofounder, was nice enough to spend some time talking to us about this unique piece of technology. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

19 Loka 201129min

Podcast #7: Low-Carb Diets with Adam Kosloff

Podcast #7: Low-Carb Diets with Adam Kosloff

Adam Kosloff is a journalist and blogger who writes about low-carb diets (among other things).  We talk about how his knowledge has evolved over time, and the merits of low-carb dieting.  Adam shares tips on how to make low-carb diets work for you, such as exercise recommendations, tricks to kill carb cravings, and how to overcome the hardest part about eating low-carb. Sign up to have these interviews delivered straight to your email or RSS(subscribing to the podcast makes you Bulletproof). See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

11 Loka 201135min

Podcast #6: Optimum Performance Training with James Fitzgerald

Podcast #6: Optimum Performance Training with James Fitzgerald

28 Syys 201127min

#5: How To Quantify Fatigue Like Never Before

#5: How To Quantify Fatigue Like Never Before

Rick Green and John Kalns have created the first test that can objectively measure fatigue.  Using an at-home test for salivary peptides, you can now gauge exactly how much stress your body is under.  This test can be used by athletes, or businessmen and entrepreneurs who burn the candle at both ends.  This is the first test which allows you to know when you’re really pushing your self too far. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

19 Syys 201139min

#4: Evolutionary Psychiatry With Emily Deans (Paleo Brain Hacking)

#4: Evolutionary Psychiatry With Emily Deans (Paleo Brain Hacking)

Emily Deans is a board certified adult psychiatrist who uses evolutionary clues to solve modern mental illnesses.  She runs a popular blog called Evolutionary Psychiatry, and another blog on psychology today.  Emily is considered one of the top experts on the connection between nutrition and mental performance.  She is well respected in the “paleosphere”, and was kind enough to share her knowledge on Upgraded Self Radio. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

14 Syys 20111h

#3: Hacking Fatigue With Tim Noakes (Plus More 4 Hour Body Fun)

#3: Hacking Fatigue With Tim Noakes (Plus More 4 Hour Body Fun)

Dr. Tim Noakes is one of the world’s foremost exercise scientists and the author of numerous books including the Lore of Running.  From the University of Cape Town exercise research center, Dr. Noakes has worked with some of the greatest athletes of all time.  His research is redefining the way we think about fatigue in sports and regular life.  A lifelong runner (71 marathons and ultra-marathons), writer, and researcher (and more recently, a paleo eater), Tim Noakes has used his knowledge to hack the human mind for improved athletic performance.  Whether you’re an athlete or a cubicle dweller, you need to here this interview. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

5 Syys 20111h

#2: The Dark Side of Fat Loss With Sean Croxton

#2: The Dark Side of Fat Loss With Sean Croxton

29 Elo 201153min

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