233: NuA3 structure reveals the mechanism of H3K14 acetylation
Shi W et al., Mechanistic insights into histone recognition and H3K14 acetylation by the NuA3 histone acetyltransferase complex - Cryo-EM structures of the yeast NuA3 complex show a composite histone ...
19 Joulu 202518min
232: Lamin A/C steers fork restart via H3K9me3 and PARylation
Cherdyntseva V et al., Nat Commun - Nucleoplasmic Lamin A/C, together with LAP2α, enforces active replication fork slowing during mild replication stress by promoting local H3K9me3 and ADP-ribosylatio...
18 Joulu 202517min
231: Transcription start sites as a germline mutational hotspot
Cortés Guzmán M et al., Nat Commun - This study identifies a pronounced germline mutational hotspot centered on transcription start sites (TSSs) driven in part by early embryonic mosaic variants and t...
17 Joulu 202517min
230: MIDEAS Y654S hyperactivates MiDAC in a dominant neurodevelopmental syndrome
Sirvydis K et al., Nat Commun - A recurrent de novo MIDEAS p.Tyr654Ser variant disrupts an autoinhibitory loop in the MiDAC complex, increasing HDAC1 deacetylase activity and causing a multisystem neu...
17 Joulu 202518min
229: Inhibiting PCBP2 condensates in Alzheimer’s
Wang L et al., Nat Commun - Elevated PCBP2 forms liquid-like condensates that sequester mitochondrial and RNA-binding proteins, stabilize BACE1 mRNA, and promote amyloid pathology while the small mole...
15 Joulu 202519min
228: Two non-competing H3N2 stem antibodies reveal evolving antigenicity
Gopal AB et al., Nat Commun - Structural and functional characterization of two group 2 H3 HA stem antibodies, 2F02 and AG2-G02, shows distinct non-overlapping epitopes, protection in mice, and antige...
14 Joulu 202518min
227: 1q gain enables rescue of aneuploid hESCs during RPE differentiation
Couvreu de Deckersberg E et al., Nat Commun (2025) - This study shows that spontaneous RPE differentiation eliminates most aneuploid human pluripotent stem cells but permits expansion of cells with ch...
13 Joulu 202516min
226: FGF4 protects podocytes in diabetic kidney disease
Wang S et al., Nat Commun - This study shows that podocyte-derived FGF4 is reduced in DKD and that recombinant FGF4 preserves podocyte survival and glomerular function in diabetic models via FGFR1-AMP...
12 Joulu 202516min
