225: VRK-1, BAF-1 and the release of meiotic chromatin
Paouneskou D et al., Nature Communications - VRK-1 phosphorylates BAF-1 to remove chromatin from the nuclear periphery during early meiotic prophase in C. elegans, and failure of this step impairs pai...
10 Joulu 202517min
224: Biohybrid implants: wireless sensing with engineered bacteria
Bilir A et al., Wireless in-body sensing through genetically engineered bacteria - A bio-hybrid, battery-free implant converts engineered bacterial activity into microwave backscatter signals by contr...
10 Joulu 202518min
223: Torsion Controls Replication: Stall and Restart
Xiaomeng Jia et al., Berger, Smita S - New single-molecule angular optical trap assays reveal that DNA torsion directly controls T7 replisome stalling and reactivation. Key terms: DNA replication, tor...
9 Joulu 202516min
222: snaR-A disrupts mRNA splicing in cancer
Zhou S et al., Nat Commun - This episode examines how the cancer-associated Pol III transcript snaR-A binds core splicing factors, localizes near nuclear speckles, perturbs U2-dependent splicing to in...
8 Joulu 202517min
221: Allele-resolved nanopore tour of the human placental methylome
Kindlova M et al., Nat Commun - Using phased long-read nanopore and short-read sequencing across eight trios, the study maps allele-specific DNA methylation and transcription in female human placentas...
7 Joulu 202520min
220: AML cell states reveal NPM1 immune-evasion subtypes
Lilljebjörn H et al., Nat Commun - Single-cell and bulk sequencing of 120 AML cases reveal two NPM1-mutated subtypes with distinct immune evasion mechanisms and divergent responses to hematopoietic st...
6 Joulu 202515min
219: Multi-omic mapping of lipid dysregulation in Parkinson’s brain
Hällqvist J et al., Nature Communications - Targeted multi-region lipidomics with proteomic and mitochondrial data reveals region- and stage-specific lipid alterations in Parkinson’s disease that conv...
6 Joulu 202516min
218: SIM1 and the multi-ancestry genomics of erectile dysfunction
Bright U et al., Nat Commun - A large multi-ancestry GWAS meta-analysis identifies a dominant SIM1-linked locus and multiple genetic connections between electronic health record-defined erectile dysfu...
4 Joulu 202519min
