Base by Base
Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical relevance—one base at a time. Powered by AI, Base by Base offers a new way to learn on the go. Special thanks to authors who publish under CC BY 4.0, making open-access science faster to share and easier to explore.

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Jaksot(441)

209: PERT: Prime Editing tRNAs for Nonsense Mutations

209: PERT: Prime Editing tRNAs for Nonsense Mutations

PERT: Prime Editing tRNAs for Nonsense Mutations Music:Enjoy the music based on this article at the end of the episode. DOI:10.1038/s41586-025-09732-2 License:This episode is based on an open-acces...

25 Marras 202516min

208: ZAK, Collided Ribosomes, and the Stress Switch

208: ZAK, Collided Ribosomes, and the Stress Switch

ZAK, Collided Ribosomes, and the Stress Switch Music:Enjoy the music based on this article at the end of the episode. DOI:10.1038/s41586-025-09772-8 License:This episode is based on an open-access ...

24 Marras 202515min

207: Semantic Design of de novo Genes with Evo

207: Semantic Design of de novo Genes with Evo

Semantic Design of de novo Genes with Evo Music:Enjoy the music based on this article at the end of the episode. DOI:10.1038/s41586-025-09749-7 License:This episode is based on an open-access artic...

24 Marras 202515min

206: Wild Birds and the North American H5N1 Epizootic

206: Wild Birds and the North American H5N1 Epizootic

Wild Birds and the North American H5N1 Epizootic Music:Enjoy the music based on this article at the end of the episode. License:This episode is based on an open-access article published under the Cr...

22 Marras 202517min

205: Ancient RNA Expression Profiles from the Woolly Mammoth

205: Ancient RNA Expression Profiles from the Woolly Mammoth

Ancient RNA Expression Profiles from the Woolly Mammoth Music:Enjoy the music based on this article at the end of the episode. License:This episode is based on an open-access article published under...

21 Marras 202517min

204: StealTHY CRISPR: Revealing Hidden Metastasis Regulators

204: StealTHY CRISPR: Revealing Hidden Metastasis Regulators

StealTHY CRISPR: Revealing Hidden Metastasis Regulators Music:Enjoy the music based on this article at the end of the episode. License:CC BY 4.0 International License (CC BY 4.0) Support:Base by Ba...

20 Marras 202516min

203: Divergent Evolutionary Dynamics of Benign and Malignant Tumors

203: Divergent Evolutionary Dynamics of Benign and Malignant Tumors

Divergent Evolutionary Dynamics of Benign and Malignant Tumors Music:Enjoy the music based on this article at the end of the episode. License:This episode is based on an open-access article publishe...

19 Marras 202518min

202: Stereo-seq V2: Spatial Total RNA Mapping in FFPE Tissues

202: Stereo-seq V2: Spatial Total RNA Mapping in FFPE Tissues

Stereo-seq V2: Spatial Total RNA Mapping in FFPE Tissues Music:Enjoy the music based on this article at the end of the episode. License:CC BY 4.0 International License (CC BY 4.0) Support:Base by B...

19 Marras 202517min

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