ASH 2025 | PARADIGM: Azacitidine + venetoclax vs conventional induction in fit adults with ND AML
AML Hub18 Des 2025

ASH 2025 | PARADIGM: Azacitidine + venetoclax vs conventional induction in fit adults with ND AML

Following the 67th American Society of Hematology (ASH) Annual Meeting and Exposition, December 6–9, 2025, Orlando, US, the AML Hub was pleased to speak with Amir Fathi, Massachusetts General Hospital, Boston, US. We asked, How might the phase II PARADIGM trial data impact treatment decisions for newly diagnosed fit adults with acute myeloid leukemia (AML)?


In this interview, Fathi discussed key findings from the open-label, randomized, phase II PARADIGM trial comparing azacitidine + venetoclax with conventional induction chemotherapy in functionally fit patients with newly diagnosed AML (NCT04801797). The primary endpoint was event-free survival.


This educational resource is independently supported by AbbVie. All content was developed by SES in collaboration with an expert steering committee. Funders were allowed no influence on the content of this resource.

Hosted on Acast. See acast.com/privacy for more information.

Episoder(35)

Should pre-transplant MRD be used to guide treatment in AML?

Should pre-transplant MRD be used to guide treatment in AML?

During the EHA2021 Virtual Congress, the AML Hub spoke with Gert Ossenkoppele, Amsterdam UMC, Amsterdam, NL. We asked, Should pre-transplant minimal residual disease (MRD) be used to guide treatment i...

23 Jun 20215min

Can HMA maintenance therapy improve eligibility for HSCT?

Can HMA maintenance therapy improve eligibility for HSCT?

During the 2021 TCT Meetings Digital Experience, the AML Hub spoke to Farhad Ravandi, MD Anderson Cancer Center, Houston, US. We asked, Can HMA maintenance therapy improve eligibility for HSCT? Ravand...

17 Mar 20215min

ALLG AMLM16: Does sorafenib plus intensive chemotherapy improve outcome in FLT3-ITD AML?

ALLG AMLM16: Does sorafenib plus intensive chemotherapy improve outcome in FLT3-ITD AML?

During the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, the AML Hub spoke to Andrew Wei, The Alfred Hospital, Melbourne, AU, and Natasha S. Anstee, The Alfred Hospital & Mo...

2 Feb 202116min

Venetoclax combinations in mutant AML subtypes: IDH1/2

Venetoclax combinations in mutant AML subtypes: IDH1/2

During the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, the AML Hub spoke to Daniel Pollyea, University of Colorado School of Medicine, Aurora, US, about venetoclax combina...

25 Jan 20216min

Venetoclax combinations in mutant AML subtypes podcast: FLT3

Venetoclax combinations in mutant AML subtypes podcast: FLT3

During the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, the AML Hub spoke to Naval Daver, MD Anderson Cancer Center, Houston, US, about venetoclax combinations in patients ...

20 Jan 202112min

Introduction to a series of podcasts on the use of venetoclax combinations in mutation subtypes of AML

Introduction to a series of podcasts on the use of venetoclax combinations in mutation subtypes of AML

During the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, the AML Hub spoke to Courtney D. DiNardo, MD Anderson Cancer Center, Houston, US, about the use of venetoclax combin...

20 Jan 20218min

How close are we to offering treatment tailored to mutational profile?

How close are we to offering treatment tailored to mutational profile?

During the European School of Haematology (ESH) 2nd How to Diagnose and Treat: Acute Leukaemia meeting, the AML Hub spoke to Jorge Sierra, Hospital de la Santa Creu i Sant Pau, Barcelona, ES. In this ...

8 Jul 20205min

Approaches and emerging therapies for TP53 AML

Approaches and emerging therapies for TP53 AML

During the 25th Congress of the European Hematology Association (EHA), the AML Hub spoke to a member of our steering committee, Naval Daver, The University of Texas MD Anderson Cancer Center, Houston,...

1 Jul 202014min

Populært innen Fakta

fastlegen
dine-penger-pengeradet
relasjonspodden-med-dora-thorhallsdottir-kjersti-idem
treningspodden
rss-strid-de-norske-borgerkrigene
foreldreradet
jakt-og-fiskepodden
rss-kunsten-a-leve
rss-sunn-okonomi
hverdagspsyken
gravid-uke-for-uke
merry-quizmas
lederskap-nhhs-podkast-om-ledelse
rss-mann-i-krise-med-sagen
sinnsyn
fryktlos
hagespiren-podcast
rss-impressions-2
level-up-med-anniken-binz
rss-mind-body-podden