WOrM Podcast: Whole Organism Analytics Podcast5 Mar 2025

EPISODE 3: The Hidden Mechanical Properties of Biological Surfaces – Brillouin Endo-Microscopy

In this episode, we uncover a revolutionary approach to imaging the hidden mechanical properties of biological surfaces using Label-Free Brillouin Endo-Microscopy. Unlike traditional imaging techniques that rely on fluorescent labels, this method provides quantitative 3D viscoelastic mapping at the sub-micrometre scale—offering unprecedented insights into biological structures.

🔍 Key Topics Covered:

• How Brillouin scattering enables real-time mechanical imaging of living tissue

• First-ever 3D stiffness mapping of Caenorhabditis elegans cuticle in situ

• Potential applications for non-invasive diagnostics and disease research

• The future of elasticity-based biomedical imaging

📖 Based on the research article:

“Label-Free Brillouin Endo-Microscopy for the Quantitative 3D Imaging of Sub-Micrometre Biology”

Salvatore La Cavera III, Veeren M. Chauhan, et al. Published in Communications Biology (2024).

🔗 Read it here: https://doi.org/10.1038/s42003-024-06126-4

Join us as we explore how this breakthrough could transform biomedical imaging, mechanobiology, and in vivo diagnostics!

🎧 Subscribe to the WoRM Podcast for more deep dives into groundbreaking research!

This podcast is generated with artificial intelligence and curated by Veeren. If you’d like your publication featured on the show, please get in touch.

📩 More info:

🔗 www.veerenchauhan.com

📧 veeren.chauhan@nottingham.ac.uk

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