EPISODE 31: Longevity Legacy – Lysosomes Write Lifespan into the Epigenome

EPISODE 31: Longevity Legacy – Lysosomes Write Lifespan into the Epigenome

How can a worm’s intestine influence its descendants’ lifespan? This episode explores how lysosomes send metabolic signals through the epigenome to extend longevity across generations.


Researchers found that activating lysosomal lipid metabolism triggers transcriptional up-regulation of a histone variant, H3.3 (his-71), in the intestine. This histone is transported to the germ line, where it’s methylated at K79 by the methyltransferase DOT-1.3. The result is a heritable epigenetic state that promotes longer life across multiple generations of C. elegans.


The work reveals how metabolic signalling through lysosomes interacts with chromatin to link soma and germ line, showing how environmental changes like starvation can shape longevity inheritance.


📖 Based on: Zhang Q., Dang W., Wang M.C. Science (2025). “Lysosomes signal through the epigenome to regulate longevity across generations.” https://doi.org/10.1126/science.adn8754


🎧 Subscribe to the WOrM Podcast for more deep dives into the molecular lives of worms.


This podcast is generated with artificial intelligence and curated by Veeren. If you’d like your publication featured on the show, please get in touch.


📩 More info:

🔗 ⁠⁠www.veerenchauhan.com⁠⁠

📧 veeren.chauhan@nottingham.ac.uk

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Episoder(53)

EPISODE 53: Worms on Pause

EPISODE 53: Worms on Pause

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EPISODE 52: Worms in Space: Microbiomes in a Capsule

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EPISODE 51: The Worm Behind the Wild

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EPISODE 50: Fed by Mum, Built by Ribosomes

EPISODE 50: Fed by Mum, Built by Ribosomes

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EPISODE 49: Glowing up the Worm Proteome

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EPISODE 48: Murder Mode: How a Worm Evolved the Urge to Kill

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EPISODE 47: When Bacteria Fight Back: Bioplastic Kills the Worm

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EPISODE 46: Turning in Time: Neural Sequences in the Worm Brain

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