#113 – Manolis Kellis: Human Genome and Evolutionary Dynamics

Jack Barsky is a former KGB spy and author of "Deep Undercover: My Secret Life and Tangled Allegiances as a KGB Spy in America". Please support this podcast by checking out our sponsors: - InsideTracker: https://insidetracker.com/lex to get 20% off - Notion: https://notion.com/startups to get up to $1000 off team plan - BetterHelp: https://betterhelp.com/lex to get 10% off - Blinkist: https://blinkist.com/lex and use code LEX to get 25% off premium - Athletic Greens: https://athleticgreens.com/lex and use code LEX to get 1 month of fish oil EPISODE LINKS: Jack's Twitter: https://twitter.com/deepcoverbarsky Jack's Website: https://jackbarsky.com Deep Undercover (book): https://amzn.to/39XMTgG The Agent (podcast): https://cumuluspodcastnetwork.com/pods/the-agent PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (06:52) - KGB (19:43) - Communism (38:45) - Childhood (45:32) - Becoming a KGB agent (1:24:04) - Training (1:37:53) - Language (1:43:45) - Moscow (1:58:45) - Spying (2:15:43) - Putin (2:18:35) - War in Ukraine (2:30:02) - Putin in the KGB (2:36:56) - Yuri Bezmenov (2:47:33) - FSB and CIA (2:55:24) - Putin and Zelenskyy (3:04:13) - Quitting the KGB (3:30:32) - Love and regrets (3:38:44) - Mortality

9 Jul 20223h 43min

Joe Rogan is a comedian, UFC commentator, and host of the Joe Rogan Experience. Please support this podcast by checking out our sponsors: - Theragun: https://therabody.com/lex - Athletic Greens: https://athleticgreens.com/lex and use code LEX to get 1 month of fish oil - InsideTracker: https://insidetracker.com/lex to get 20% off - Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get special savings - ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free EPISODE LINKS: Joe's Instagram: https://instagram.com/joerogan Joe's Twitter: https://twitter.com/joerogan JRE (Spotify): https://open.spotify.com/show/4rOoJ6Egrf8K2IrywzwOMk JRE (YouTube): https://youtube.com/c/joerogan PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (09:03) - Discipline (13:06) - Controversy (33:22) - UFOs and aliens (43:34) - Intelligence agencies (48:58) - Trust (54:21) - Greatest comedians (1:12:16) - Childhood (1:19:46) - Advice for young people (1:30:22) - Relationships (1:35:00) - Putin, Ukraine, and Russia

4 Jul 20221h 49min

Demis Hassabis is the CEO and co-founder of DeepMind. Please support this podcast by checking out our sponsors: - Mailgun: https://lexfridman.com/mailgun - InsideTracker: https://insidetracker.com/lex to get 20% off - Onnit: https://lexfridman.com/onnit to get up to 10% off - Indeed: https://indeed.com/lex to get $75 credit - Magic Spoon: https://magicspoon.com/lex and use code LEX to get $5 off EPISODE LINKS: Demis's Twitter: https://twitter.com/demishassabis DeepMind's Twitter: https://twitter.com/DeepMind DeepMind's Instagram: https://instagram.com/deepmind DeepMind's Website: https://deepmind.com Plasma control paper: https://nature.com/articles/s41586-021-04301-9 Quantum simulation paper: https://science.org/doi/10.1126/science.abj6511 The Emperor's New Mind (book): https://amzn.to/3bx03lo Life Ascending (book): https://amzn.to/3AhUP7z PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:17) - Turing Test (14:43) - Video games (36:18) - Simulation (38:29) - Consciousness (43:29) - AlphaFold (57:09) - Solving intelligence (1:09:28) - Open sourcing AlphaFold & MuJoCo (1:19:34) - Nuclear fusion (1:23:38) - Quantum simulation (1:26:46) - Physics (1:30:13) - Origin of life (1:34:52) - Aliens (1:42:59) - Intelligent life (1:46:08) - Conscious AI (1:59:23) - Power (2:03:53) - Advice for young people (2:11:59) - Meaning of life

1 Jul 20222h 17min

Susan Cain is the author of Quiet: The Power of Introverts in a World That Can't Stop Talking, and Bittersweet: How Sorrow and Longing Make Us Whole. Please support this podcast by checking out our sponsors: - Brave: https://brave.com/lex - Skiff: https://skiff.org/lex to get early access - Mizzen+Main: https://mizzenandmain.com and use code LEX to get $35 off - Athletic Greens: https://athleticgreens.com/lex and use code LEX to get 1 month of fish oil - InsideTracker: https://insidetracker.com/lex to get 20% off EPISODE LINKS: Susan's Twitter: https://twitter.com/susancain Susan's Instagram: https://instagram.com/susancainauthor Susan's Website: https://susancain.net Bittersweet (book): https://amzn.to/3xE0LWt Quiet (book): https://amzn.to/3QvpOmb PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (06:42) - Introverts (24:42) - Small talk (29:37) - Artistic expression (42:03) - Sad music (49:42) - Leonard Cohen (1:00:34) - Public speaking (1:07:50) - Podcasts (1:15:25) - Famous Blue Raincoat by Leonard Cohen (1:30:47) - Creativity and sadness (1:39:03) - Dark moments (1:47:06) - Parenting (1:55:59) - Advice for young people (1:59:10) - Meaning of life

28 Jun 20222h 5min

Jonathan Reisman is a physician and author of The Unseen Body who has practiced medicine in some of the most remote places in the world. Please support this podcast by checking out our sponsors: - Lambda: https://lambdalabs.com/lex - InsideTracker: https://insidetracker.com/lex to get 20% off - Fundrise: https://fundrise.com/lex - Onnit: https://lexfridman.com/onnit to get up to 10% off - NetSuite: http://netsuite.com/lex to get free product tour EPISODE LINKS: Jonathan's Twitter: https://twitter.com/jonreismanMD Jonathan's Instagram: https://instagram.com/jonreismanmd Jonathan's Website: http://jonathanreisman.com The Unseen Body (book): https://amzn.to/3Fyycw0 PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:01) - Hands (16:15) - Sex (25:56) - Future of medicine (35:03) - Throat (45:26) - Heart and blood (53:28) - Genitals (1:05:57) - Poop (1:10:12) - Emergency room (1:18:03) - Sperm (1:23:09) - Liver (1:28:38) - Living in the Far North (1:47:21) - War and medicine (1:52:07) - Antarctica (2:05:03) - Artificial organs (2:13:39) - History of medicine (2:22:40) - Paul Farmer (2:27:05) - Advice for young people (2:34:03) - Struggle (2:40:07) - Mortality (2:45:44) - Meaning of life

25 Jun 20222h 49min

Douglas Murray is an author and political commentator. Please support this podcast by checking out our sponsors: - Brave: https://brave.com/lex - BetterHelp: https://betterhelp.com/lex to get 10% off - BiOptimizers: http://www.magbreakthrough.com/lex to get 10% off - Notion: https://notion.com/startups to get up to $1000 off team plan - ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free EPISODE LINKS: Douglas's Twitter: https://twitter.com/DouglasKMurray Douglas's Instagram: https://instagram.com/douglaskmurray Douglas's Website: https://douglasmurray.net The War on the West (book): https://amzn.to/38L7B36 Madness of Crowds (book): https://amzn.to/3MShBpX Strange Death of Europe (book): https://amzn.to/3OnYmEX PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:49) - Western civilization (16:29) - Slavery (20:06) - Reparations (25:11) - Institutional racism (32:24) - Lived experience (41:49) - Resentment (53:55) - Critical race theory (1:08:27) - Racism (1:27:26) - Stalin (1:31:59) - Churchill (1:38:03) - Marxism (1:54:41) - Madness of Crowds (2:03:14) - Ego (2:10:22) - Donald Trump (2:17:06) - America's future (2:24:33) - Advice for young people (2:33:16) - Love

21 Jun 20222h 44min

Richard Wolff is a Marxist philosopher and economist. Please support this podcast by checking out our sponsors: - Skiff: https://skiff.org/lex to get early access - Indeed: https://indeed.com/lex to get $75 credit - Onnit: https://lexfridman.com/onnit to get up to 10% off - Blinkist: https://blinkist.com/lex and use code LEX to get 25% off premium - Linode: https://linode.com/lex to get $100 free credit EPISODE LINKS: Richard's Twitter: https://twitter.com/profwolff Richard's Website: https://www.rdwolff.com Contending Economic Theories (book): https://amzn.to/3HykPwT Understanding Marxism (book): https://amzn.to/39qpm8b Understanding Socialism (book): https://amzn.to/3Og9XG3 PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:12) - Marxism (15:41) - Communism (50:47) - Human nature (1:03:03) - Economics (1:09:54) - Capitalism (1:42:18) - Governments and corporations (1:53:13) - Stalinism (2:07:12) - Nazis (2:14:08) - Socialism vs Marxism (2:21:48) - Bernie Sanders and AOC (2:38:49) - Cultural Marxism (2:45:49) - Darkest moments (2:51:18) - Advice for young people (2:53:37) - Mortality (2:57:28) - Meaning of life

17 Jun 20222h 59min

Tony Fadell is an engineer and designer, co-creator of the iPod, iPhone, Nest Thermostat, and author of the new book Build: An Unorthodox Guide to Making Things Worth Making. Please support this podcast by checking out our sponsors: - Mailgun: https://lexfridman.com/mailgun - Scale: https://scale.com/lex - NetSuite: http://netsuite.com/lex to get free product tour - SimpliSafe: https://simplisafe.com/lex and use code LEX - Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get special savings EPISODE LINKS: Tony's Twitter: https://twitter.com/tfadell Tony's Website: https://tonyfadell.com Build (book): https://amzn.to/3xSReee Story (book): https://amzn.to/3Olzqhv PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:16) - Memories (14:13) - Apple II (22:51) - First business (26:55) - iPod (50:56) - Ideas (55:09) - Marketing (1:05:26) - PR and Comms (1:15:06) - Design (1:20:03) - Experts (1:26:04) - Steve Jobs (2:09:43) - Jony Ive (2:16:55) - Nest (2:27:13) - Advice for young people (2:31:30) - Startup (2:36:25) - Money (2:41:33) - Work-Life Balance (2:44:11) - Darkest moment (2:49:48) - Meaning of life

15 Jun 20222h 52min