#113 – Manolis Kellis: Human Genome and Evolutionary Dynamics

Lee Cronin is a chemist at the University of Glasgow. Please support this podcast by checking out our sponsors: - Paperspace: https://gradient.run/lex to get $15 credit - Athletic Greens: https://athleticgreens.com/lex and use code LEX to get 1 month of fish oil - Notion: https://notion.com/startups to get up to $1000 off team plan - Blinkist: https://blinkist.com/lex and use code LEX to get 25% off premium - Onnit: https://lexfridman.com/onnit to get up to 10% off EPISODE LINKS: Lee's Twitter: https://twitter.com/leecronin Lee's Website: https://www.chem.gla.ac.uk/cronin/ Chemify's Website: https://chemify.io PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (08:31) - Life and chemistry (21:56) - Self-replicating molecules (32:19) - Origin of life (48:45) - Life on Mars (53:49) - Aliens (1:00:30) - Origin of life continued (1:07:24) - Fermi Paradox (1:17:04) - UFOs (1:25:25) - Science and authority (1:31:28) - Pickle experiment (1:34:23) - Assembly theory (2:17:22) - Free will (2:28:37) - Cellular automata (2:52:08) - Chemputation (3:09:23) - Universal programming language for chemistry (3:22:34) - Chemputer safety (3:35:15) - Automated engineering of nanomaterials (3:44:15) - Consciousness (3:53:48) - Joscha Bach (4:05:04) - Meaning of life

11 Mar 20224h 12min

Robert Proctor is a historian of science at Stanford University. Please support this podcast by checking out our sponsors: - Theragun: https://therabody.com/lex to get 30 day trial - BetterHelp: https://betterhelp.com/lex to get 10% off - Indeed: https://indeed.com/lex to get $75 credit - Grammarly: https://grammarly.com/lex to get 20% off premium - Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get special savings EPISODE LINKS: Robert's Website: https://history.stanford.edu/people/robert-n-proctor The Nazi War on Cancer (book): https://amzn.to/3hjYzdZ Agnotology (book): https://amzn.to/3viS8A1 PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (09:40) - Ideology and science (21:14) - Wernher von Braun (28:21) - The scientific process (38:23) - Censorship (47:37) - Anthony Fauci (52:47) - Courage in science (1:00:07) - Tobacco industry (1:23:52) - Nazi medicine (1:34:02) - The Nazi War on Cancer (1:39:14) - Science funding (1:50:08) - Ignorance (1:57:49) - Ideology in academia (2:04:09) - Human origins (2:14:02) - Hobbies (2:21:19) - Diversity in the universe (2:24:54) - Stones (2:33:49) - Conspiracy theories (2:37:59) - Nazi impact on Soviet science (2:43:14) - Nazi tobacco industry's denial campaign (2:47:30) - Hope for the future (2:50:04) - Meaning of life

5 Mar 20222h 55min

Mark Zuckerberg is CEO of Meta, formerly Facebook. Please support this podcast by checking out our sponsors: - Paperspace: https://gradient.run/lex to get $15 credit - Coinbase: https://coinbase.com/lex to get $5 in free Bitcoin - InsideTracker: https://insidetracker.com/lex and use code Lex25 to get 25% off - ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free - Blinkist: https://blinkist.com/lex and use code LEX to get 25% off premium EPISODE LINKS: Mark's Facebook: https://facebook.com/zuck Mark's Instagram: https://instagram.com/zuck Meta AI: https://ai.facebook.com/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (11:29) - Metaverse (31:06) - Identity in Metaverse (43:15) - Security (47:40) - Social Dilemma (1:09:46) - Instagram whistleblower (1:14:31) - Social media and mental health (1:19:56) - Censorship (1:37:05) - Translation (1:44:40) - Advice for young people (1:50:28) - Daughters (1:53:16) - Mortality (1:57:49) - Question for God (2:00:55) - Meaning of life

26 Feb 20222h 5min

Nicole Perlroth is a cybersecurity journalist and author. Please support this podcast by checking out our sponsors: - Linode: https://linode.com/lex to get $100 free credit - InsideTracker: https://insidetracker.com/lex and use code Lex25 to get 25% off - Onnit: https://lexfridman.com/onnit to get up to 10% off - ROKA: https://roka.com/ and use code LEX to get 20% off your first order - Indeed: https://indeed.com/lex to get $75 credit EPISODE LINKS: Nicole's Twitter: https://twitter.com/nicoleperlroth Nicole's Website: https://nytimes.com/by/nicole-perlroth Nicole's Book: https://amzn.to/3sOQjrs PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (06:54) - Zero-day vulnerability (12:55) - History of hackers (27:47) - Interviewing hackers (31:49) - Ransomware attack (44:33) - Cyberwar (57:41) - Cybersecurity (1:06:48) - Social engineering (1:23:41) - Snowden and whistleblowers (1:33:11) - NSA (1:42:58) - Fear for cyberattacks (1:50:29) - Self-censorship (1:54:50) - Advice for young people (2:00:07) - Hope for the future

20 Feb 20222h 7min

Devon Larratt is a professional arm wrestler, widely considered to be one of the best of all time. Please support this podcast by checking out our sponsors: - Allform: https://allform.com/lex to get 20% off - Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get special savings - InsideTracker: https://insidetracker.com/lex and use code Lex25 to get 25% off - ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free - SimpliSafe: https://simplisafe.com/lex and use code LEX to get a free security camera EPISODE LINKS: Devon's Instagram: https://instagram.com/devlarratt Devon's YouTube: https://youtube.com/devlarratt Devon's Facebook: https://facebook.com/devon.larratt.5 Devon's Website: https://nolimitsarmwrestling.com/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (06:42) - Over the Top and John Brzenk (18:15) - Strength vs skill vs strategy (42:38) - Denis Cyplenkov (1:11:44) - Jodi Larratt (1:15:45) - Canadian Special Forces (1:20:19) - Arm wrestling (1:27:03) - Freedom arm wrestling (1:38:36) - Diet (1:46:00) - Devon vs The Mountain (1:57:30) - Mortality (2:03:03) - Aliens and robots

16 Feb 20220s

Tim Urban is the author and illustrator of the popular blog 'Wait But Why'. Please support this podcast by checking out our sponsors: - Audible: https://audible.com/lex to get $9.95 a month for 6 months - Paperspace: https://gradient.run/lex to get $15 credit - Coinbase: https://coinbase.com/lex to get $5 in free Bitcoin - InsideTracker: https://insidetracker.com/lex and use code Lex25 to get 25% off - NetSuite: http://netsuite.com/lex to get free product tour EPISODE LINKS: Tim's Twitter: https://twitter.com/waitbutwhy Tim's Website: https://waitbutwhy.com Tim's Instagram: https://instagram.com/timurban PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (14:54) - Aliens (23:08) - The pencil problem (29:53) - Food abundance (31:57) - Extinction of human civilization (37:15) - Future politics of Mars (44:15) - SpaceX (50:15) - Elon Musk (1:15:43) - Nuclear power (1:20:09) - The higher mind (1:24:53) - Echo chambers and idea labs (1:28:05) - How our brain processes film and music (1:31:19) - Neuralink (1:39:33) - Future of physical interactions (1:43:44) - AI (1:51:04) - Free speech (1:55:07) - How to read more (2:01:49) - Spaced repetition (2:05:52) - Procrastination (2:32:44) - Goals for the future (2:38:02) - Meaning of life

13 Feb 20222h 43min

John Abramson is faculty at Harvard Medical School and a family physician for over two decades. He's the author of the new book Sickening about how big pharma broke American healthcare and how we can fix it. Please support this podcast by checking out our sponsors: - Noom: https://trynoom.com/lex - Notion: https://notion.com/startups to get up to $1000 off team plan - InsideTracker: https://insidetracker.com/lex and use code Lex25 to get 25% off - Athletic Greens: https://athleticgreens.com/lex and use code LEX to get 1 month of fish oil - Onnit: https://lexfridman.com/onnit to get up to 10% off EPISODE LINKS: John's Website: https://hcp.hms.harvard.edu/people/john-david-abramson Sickening (book): https://amzn.to/3gsVHef Overdosed America (book): https://amzn.to/3LmrWKn PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (14:29) - Biggest problem with big pharma (23:30) - Advertising (43:22) - Corruption (59:38) - Pfizer vaccine data (1:08:30) - Vaccine profits (1:19:25) - Censorship (1:40:11) - FDA (1:48:45) - NIH (1:57:42) - Live longer (2:01:13) - Medications (2:09:37) - Doctors (2:13:44) - Advice for young people (2:14:40) - Big pharma's influence (2:19:24) - Mortality (2:21:15) - Meaning of life

11 Feb 20222h 24min

Garry Nolan is a professor at Stanford University School of Medicine. His research is in microbiology, immunology, bio-computation, and analysis of UFO artifacts, materials, and reports of UFO encounters. Please support this podcast by checking out our sponsors: - Athletic Greens: https://athleticgreens.com/lex and use code LEX to get 1 month of fish oil - InsideTracker: https://insidetracker.com/lex and use code Lex25 to get 25% off - Blinkist: https://blinkist.com/lex and use code LEX to get 25% off premium - ExpressVPN: https://expressvpn.com/lexpod and use code LexPod to get 3 months free - Eight Sleep: https://www.eightsleep.com/lex and use code LEX to get special savings EPISODE LINKS: Garry's Twitter: https://twitter.com/GarryPNolan Nolan Lab's Website: https://web.stanford.edu/group/nolan/ PODCAST INFO: Podcast website: https://lexfridman.com/podcast Apple Podcasts: https://apple.co/2lwqZIr Spotify: https://spoti.fi/2nEwCF8 RSS: https://lexfridman.com/feed/podcast/ YouTube Full Episodes: https://youtube.com/lexfridman YouTube Clips: https://youtube.com/lexclips SUPPORT & CONNECT: - Check out the sponsors above, it's the best way to support this podcast - Support on Patreon: https://www.patreon.com/lexfridman - Twitter: https://twitter.com/lexfridman - Instagram: https://www.instagram.com/lexfridman - LinkedIn: https://www.linkedin.com/in/lexfridman - Facebook: https://www.facebook.com/lexfridman - Medium: https://medium.com/@lexfridman OUTLINE: Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time. (00:00) - Introduction (07:41) - Biology (13:45) - Alien civilizations (17:49) - UFO encounters (54:50) - Atacama skeleton (1:02:07) - UFO materials (1:13:29) - Jacques Vallee (1:17:37) - UFO data (1:28:43) - Alien hardware in US possession (1:33:20) - Bob Lazar (1:36:15) - Avi Loeb and Oumuamua (1:40:17) - Advice for young people (1:47:05) - Meaning of life

6 Feb 20221h 50min