Office Hours: Cholesterol and Heart Disease — What I’ve Changed My Mind About

Office Hours: Cholesterol and Heart Disease — What I’ve Changed My Mind About

For decades, we’ve been told that high cholesterol is the main driver of heart disease—and that lowering LDL should be the primary goal. But as science has evolved, so has my thinking. In today’s Office Hours, I explain why cholesterol alone doesn’t tell the full story, what most doctors still aren’t testing, and what’s really driving heart disease for the majority of people. Today we discuss: • Why many people have heart attacks despite “normal” LDL cholesterol • The difference between cholesterol levels and cholesterol particles • How inflammation and insulin resistance fuel heart disease • Why sugar and refined starches are more dangerous than fat • The most important labs to assess real cardiovascular risk • What ApoB, lipoprotein(a), and triglyceride-to-HDL ratio reveal about your health • How metabolic dysfunction—not cholesterol alone—drives plaque buildup Heart disease is far more complex than a single lab value. When you understand the role of metabolic health, inflammation, and the right biomarkers, you can take meaningful steps to protect your heart and long-term health. Visit ⁠functionhealth.com⁠ for 160+ lab tests at just $365 a year. Helpful Resources: Join the 10-Day Detox to Reset Your Metabolic Health https://drhyman.com/pages/10-day-detox Have a question you’d love answered on Office Hours? Submit it here 👉https://docs.google.com/forms/d/e/1FAIpQLSdNF2y4lFWEOMLlzVNlFDpJ4xl7oOpH9NlImMoHr5mHggL_Ww/viewform?usp=header

Episoder(1133)

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This week, in a special holiday edition of The Dr. Hyman Show, I’m revisiting a powerful conversation with Dr. Aseem Malhotra, a leading cardiologist and advocate for ethical, evidence-based medicine,...

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As we wind down for the holiday season, we’ll be taking a short break. But I didn’t want to leave you without something meaningful to explore. So for today’s Monday episode, we’re revisiting one of ou...

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Ready to feel better than you ever have? Here are five ways to your best health in 2026—simple shifts that work faster than most people realize: food as medicine, restorative sleep, stress mastery, da...

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How Laura Modi Is Rewriting Baby Formula

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