Peptide of the Week: Testosterone Esters + TRT Protocols – Hormone Optimization & Healing With Dr. Scott Collie

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.

Welcome back, warriors! In this special Peptide of the Week episode, JD Denham and William T. Haas are joined by Dr. Scott Collie a long-time friend and hormone optimization expert to take a deep dive into blood work, testosterone replacement, ester differences, side effects, and proper protocol stacking.

This one’s all about optimizing hormones with real strategy. If you’re considering TRT or already on it, this is required listening.

Chapters:

00:00 Welcome, New Studio & Guest Introduction

03:00 Why Blood Work Matters Before TRT

08:45 Estrogen, DHT & Detox Pathways Explained

15:30 Alternatives to TRT (Clomiphene & Creams)

17:00 What Testosterone Really Does in the Body

22:20 TRT Dosing: Replacement vs Overdoing It

28:00 Supplements & Peptides to Support TRT

31:00 Testosterone Esters Explained (Cyp, Prop, Sustanon)

41:00 Injection Frequency, PIP & Carrier Oils

49:00 Diet, Fasting & Training Adjustments

52:30 MOTS-C vs SS-31 (Mitochondria Explained)

56:00 Intramuscular vs Sub-Q Peptides

57:30 Testosterone Therapy for Women

1:00:00 Final Thoughts & Wrap-Up

We cover:

🩸 Blood Work & Baseline Panels

– Why a comprehensive panel is essential before starting TRT or peptide therapy

– Inflammation markers, homocysteine, iron levels & clotting risks

– Common doctor mistakes: running only total testosterone with no free test or estrogen panels

– Genetic factors (MTHFR), detox pathways & why gut health matters for estrogen clearance

💉 TRT Side Effects & How to Avoid Them

– Estrogen conversion, DHT, prostate health & hair loss explained

– Common side effects (acne, gyno, fatigue, mood swings) and how to minimize them

– Methylation support: B6, B12, methyl folate, DIM, calcium glucarate

– Natural blood thinners: fish oil, natto kinase, bergamot, turmeric

🧬 Ester Education – From Sipionate to Propionate to Sustanon

– Fast vs slow release esters explained

– When to choose Test Prop vs Sip vs Sustanon vs Enanthate vs Undecanoate

– Daily vs weekly dosing strategies & injection protocols (IM vs SubQ)

– What "PIP" (post-injection pain) means and how to reduce it (oil type, heating, MCT vs grapeseed)

🔥 Optimal TRT Dosing

– Why 200–250mg is often too much for long-term use

– Why 125–150mg/week is the true sweet spot for most men

– Expected results timeline: 3 weeks to feel it, 6 weeks to retest, 3 months to dial it in

– Monitoring lipid panels, hematocrit, ferritin, homocysteine over time

🧪 Stacking with Peptides

– Using TB-500 and BPC-157 for injury recovery (yes, even for teens)

– Thymosin Alpha-1 for immune support alongside TRT

– When to avoid stacking GH secretagogues or MK-677 in younger athletes

– Women & TRT: microdosing for libido, bone density, mood & anemia

💡 Bonus Topics

– Intramuscular vs SubQ injection effectiveness

– Mitochondrial repair: Why SS-31 should come before MOTS-C

– Why some people feel NAD or MOTS-C — and others don’t (and why that’s okay)

📌 Bottom line: Hormone optimization isn't about blasting your body. It's about strategy, testing, and long-term health. From esters to estrogens, this episode cuts through the fluff with real talk and proven science.

🧪 This isn’t hype it’s hard data, real-world feedback, and first-hand experience.

💬 Got questions or peptide topics you want broken down? Drop a comment below.

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