Cholesterol, LDL, and what we learnt from PCSK9 mutations in familial hypercholesterolaemia
VAT Trap18 Okt 2025

Cholesterol, LDL, and what we learnt from PCSK9 mutations in familial hypercholesterolaemia

In families with inherited high cholesterol (familial hypercholesterolaemia), mutations in the PCSK9 gene have been identified which make this protein overactive. These are known as gain-of-function mutations — they increase PCSK9 activity and push LDL cholesterol to dangerous levels. For over 90% of people with raised LDL who do NOT have a mutation, there are alternative explanations outlined in a related article and for readers that are curious about this PCSK9 take a look at my technical article linked to the VAT Trap book series on LDL Cholesterol. Read blog

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Episoder(40)

Visceral Adipose Tissue (VAT) as a Major Modifiable Driver of Cardiometabolic Risk

Visceral Adipose Tissue (VAT) as a Major Modifiable Driver of Cardiometabolic Risk

Two people can share the same weight and BMI yet have completely different risks of heart attack and type 2 diabetes. The difference is often visceral fat — the hidden fat wrapped around your organs. ...

23 Jun 5min

How to Measure Your Waist

How to Measure Your Waist

Waist circumference predicts cardiometabolic risk better than weight or BMI — but only when measured at a fixed anatomical landmark: the midpoint between your lowest rib and the top of your hip bone. ...

16 Jun 1min

Why Your CGM Only Tells Half the Story

Why Your CGM Only Tells Half the Story

Your continuous glucose monitor shows exactly how bread affects blood sugar but misses the fructose pathway completely. While CGMs track glucose perfectly, they remain blind to fructose heading straig...

11 Jun 5min

The Four Pillars: A Temple for Your Healthspan

The Four Pillars: A Temple for Your Healthspan

What if living longer isn’t about finding a miracle treatment, but strengthening four foundations that support every decade of life? The Four Pillars explores cardiovascular fitness, muscle strength, ...

3 Jun 6min

How to Interpret Your Home Blood Pressure Results: What Your MyBP Numbers Actually Mean

How to Interpret Your Home Blood Pressure Results: What Your MyBP Numbers Actually Mean

A week of home blood pressure readings tells a far more accurate story than a single clinic measurement. Learn how to interpret your MyBP results, understand what the categories mean, recognise when l...

3 Jun 1min

VAT Brain

VAT Brain

Your belly fat isn't just threatening your heart — it's actively damaging your brain. Visceral adipose tissue drives the insulin resistance, inflammation and vascular damage that accelerate dementia, ...

2 Jun 10min

Is coronary artery calcification good or bad?

Is coronary artery calcification good or bad?

Coronary calcium screening has evolved from expensive research tool to mainstream risk assessment, but fixation on Agatston scores obscures sophisticated plaque analysis. Zero calcium cannot exclude d...

31 Mai 23min

The VAT Trap: Understanding the Metabolic Doom Loop

The VAT Trap: Understanding the Metabolic Doom Loop

Most metabolic problems start years before symptoms appear. Visceral fat creates a self-perpetuating cycle of inflammation and insulin resistance that drives diabetes, heart disease, and weight gain. ...

30 Mai 5min

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