Clinical Insights Into CASPR1 and CASPR1/Contactin-1 Complex Autoimmune Nodopathies

Clinical Insights Into CASPR1 and CASPR1/Contactin-1 Complex Autoimmune Nodopathies

Dr. Alex Menze and Dr. Divyanshu Dubey discuss the clinical insights into autoimmune nodopathies, particularly focusing on CASPR1 and CASPR1/CNTN1-complex-IgG.

Show citation:

Paramasivan NK, Basal E, LaFrance-Corey RG, et al. Clinical Insights Into CASPR1 and CASPR1/Contactin-1 Complex Autoimmune Nodopathies. Neurology. 2026;106(5):e214403. doi:10.1212/WNL.0000000000214403

Show transcript:

Dr. Alexander Menze:

Hi, this is Alexander Menze. I just finished interviewing Divyanshu Dubey for the Neurology podcast. For today's Neurology Minute, I'm hoping you can tell us the main points of your paper.

Dr. Divyanshu Dubey:

Our paper talks about a rare form of autoimmune neuropathy associated with antibodies, CASPR1, as well as CASPR1/Contactin-1 complex IgG. These patients present with similar to CIDP, IDP, but tend to have more rapid progression, often a lot of sensory features preceding motor deficits including sensory ataxia in the contact and CASPR complex cases and presence of neuropathic pain in some of the CASPR1 cases. These patients, similar to other neuropathies are refractory to IVIg, but respond relatively well to rituximab.

Dr. Alexander Menze:

Thank you. Be sure to download this week's podcast to hear our full interview.

Denne episoden er hentet fra en åpen RSS-feed og er ikke publisert av Podme. Den kan derfor inneholde annonser.

Episoder(1940)

New Resident Guide to Stroke Alerts - Part 2

New Resident Guide to Stroke Alerts - Part 2

In part two of this series, Dr. Andy Southerland and Dr. Dan Ackerman discuss a few rapid‑fire concepts from the 2026 guidelines, focusing on what is new and how emerging data may shape patient care. ...

5 Jun 4min

New Resident Guide to Stroke Alerts - Part 1

New Resident Guide to Stroke Alerts - Part 1

In part one of this series, Dr. Andy Southerland and Dr. Dan Ackerman discuss what stands out in the latest thrombolysis guidelines, how these decisions are applied in stroke center practice, and how ...

4 Jun 4min

Understanding Rett Syndrome - Part 3

Understanding Rett Syndrome - Part 3

In the third episode of this series, Dr. Stacey Clardy discusses treatment options and ongoing management. Show transcript:  Dr. Stacey Clardy: This is The Neurology Minute. I'm Stacey Clardy from the...

3 Jun 2min

Shunting for Idiopathic Normal Pressure Hydrocephalus

Shunting for Idiopathic Normal Pressure Hydrocephalus

Dr. Margarita Fedorova discusses the effectiveness of shunting for idiopathic normal pressure hydrocephalus.  Show citation:  Luciano MG, Williams MA, Hamilton MG, et al. A Randomized Trial of Shuntin...

2 Jun 3min

Recent Updates in Central Retinal Artery Occlusions

Recent Updates in Central Retinal Artery Occlusions

Dr. Casandra MacLeod discusses central retinal artery occlusions, recent trials, and those anticipated in the future.  Show citation:  Préterre C, Gaultier A, Obadia M, et al. Intravenous alteplase ve...

1 Jun 3min

Prion Disease Clinical Trial NN112

Prion Disease Clinical Trial NN112

Dr. Gregg Day and Drs. Sonia Vallabh and Eric Minikel discuss scientific insights and the future of prion disease treatment, highlighting the importance of early diagnosis, personalized medicine, and ...

29 Mai 1min

Headache Medicine Highlights from the 2026 AAN Annual Meeting - Part 2

Headache Medicine Highlights from the 2026 AAN Annual Meeting - Part 2

In the second episode of this series, Dr. Tesha Monteith and Dr. Peter Goadsby discuss the prediction of treatment responses for personalized medicine. Show transcript: Dr. Tesha Monteith:  Hi, this i...

28 Mai 1min

Understanding Rett Syndrome - Part 2

Understanding Rett Syndrome - Part 2

In the second episode of a four-part series on Rett syndrome, Dr. Stacey Clardy discusses the importance of early referrals, particularly during the regression phase.  Show transcript:  Dr. Stacey Cla...

27 Mai 2min

Populært innen Helse

fastlegen
rss-gukild-johaug
lydartikler-fra-aftenposten
psykodrama
hvordan-har-du-det-mann
leger-om-livet
relasjonspodden-med-dora-thorhallsdottir-kjersti-idem
rss-garne-damer
foreldreradet
rss-skravla-gar
bak-fasaden-en-reise-i-livet-med-sykepleier-ine
morten-ramm-lar-kakla-ga-til-du-sovner
klimaks
rss-lopedrommen
hjernesterk
g-punktet
rss-loping-for-nybegynnere
sinnsyn
treningsprat
rss-maren-mina