HFpEF: Normal by Echo, Abnormal by Hemodynamics | JACC Baran

HFpEF: Normal by Echo, Abnormal by Hemodynamics | JACC Baran

Hosts Mitsuaki Sawano, MD, and Satoshi Shoji, MD welcome Dr. Tomonari Harada, MD, PhD (Mayo Clinic / Gunma University) with commentary from Dr. Masaru Obokata, MD (Gunma University) to discuss their JACC study, “Echocardiographic Diastolic Function Grading in HFpEF: Testing the Updated 2025 ASE Criteria.” This investigation applies the newly updated 2025 ASE diastolic function grading algorithm to invasively confirmed HFpEF cohorts and examines how frequently patients may be classified as “Normal” or “Grade 1” despite established disease. Across compensated outpatient HFpEF, acute decompensated admissions, and external validation cohorts, the study highlights substantial false-negative classifications, limited discrimination from noncardiac dyspnea, and dynamic grade shifts with changes in congestion status. The episode explores the clinical implications: why diastolic grade alone should not be used to exclude HFpEF, how exercise criteria perform in real-world cohorts, and why integrating pre-test probability and HFpEF-specific frameworks remains essential in contemporary heart failure evaluation.

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Episoder(93)

ICI Myocarditis: Does Timing Define the Disease? | JACC Baran

ICI Myocarditis: Does Timing Define the Disease? | JACC Baran

Is immune checkpoint inhibitor (ICI)-associated myocarditis the same disease when it occurs early versus months after starting cancer therapy? Host Mitsuaki Sawano, MD, and co-host Shun Kohsaka, MD, w...

3 Nov 34min

ICI Myocarditis: Does Timing Define the Disease? | JACC Baran

ICI Myocarditis: Does Timing Define the Disease? | JACC Baran

Is immune checkpoint inhibitor (ICI)-associated myocarditis the same disease when it occurs early versus months after starting cancer therapy? Host Mitsuaki Sawano, MD, and co-host Shun Kohsaka, MD, w...

3 Nov 34min

Does PFA Reach the Vein of Marshall? | JACC Baran

Does PFA Reach the Vein of Marshall? | JACC Baran

Does pulsed field ablation (PFA) for pulmonary vein isolation affect structures beyond the pulmonary veins? Host Mitsuaki Sawano, MD, welcomes Yosuke Nakatani, MD (Gunma University) to discuss his rec...

27 Okt 36min

A SELUTION to Paclitaxel DCB Complications in PAD? | JACC Baran

A SELUTION to Paclitaxel DCB Complications in PAD? | JACC Baran

Could sirolimus-coated balloons change how we treat femoropopliteal peripheral artery disease? Host Mitsuaki Sawano, MD, welcomes Yoshimitsu Soga, MD, PhD (Kokura Memorial Hospital) to discuss the 3-y...

20 Okt 28min

Proteomics in Action: Finding the Right Drug Targets for Ischemic Heart Disease | JACC Baran

Proteomics in Action: Finding the Right Drug Targets for Ischemic Heart Disease | JACC Baran

Which of the thousands of biomarkers associated with cardiovascular disease could actually become a useful drug target? Host Mitsuaki Sawano, MD, and co-host Nobuhiro Ikemura, MD, welcome Satoshi Yosh...

13 Okt 35min

PET Unmasks CMD: The Hidden Risk Behind Normal Perfusion | JACC Baran

PET Unmasks CMD: The Hidden Risk Behind Normal Perfusion | JACC Baran

Hosts Mitsuaki Sawano, MD, Satoshi Shoji, MD, and Kentaro Ejiri, MD, welcome Yoshito Kadoya, MD, PhD (University of British Columbia / St. Paul’s Hospital) to discuss his JACC: Cardiovascular Imaging ...

6 Okt 36min

Rethinking Health Care at Home and Abroad: Lancet RH Western Pacific Special | JACC Baran

Rethinking Health Care at Home and Abroad: Lancet RH Western Pacific Special | JACC Baran

Host Mitsuaki Sawano, MD, welcomes Shuhei Nomura, PhD (Tohoku University), Lisa Yamasaki, MD (Harvard T.H. Chan School of Public Health), and Haruka Sakamoto, MD, PhD (St. Luke’s International Hospita...

29 Sep 39min

PFA Changes the Game and the AT Circuit | JACC Baran

PFA Changes the Game and the AT Circuit | JACC Baran

Hosts Mitsuaki Sawano, MD, and Hiroyuki Sato, MD, welcome Kazutaka Nakasone, MD (Kobe University) to discuss his JACC: Clinical Electrophysiology study on atrial tachycardia (AT) after pulsed field ab...

22 Sep 36min

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