Behind The Knife: The Surgery Podcast30 Mar

Clinical Challenges in Transplant Surgery: How Xenotransplantation Will Change Our Lives

Xenotransplantation—the use of organs from other species to treat human disease—has long existed at the intersection of science fiction and surgical innovation. While early efforts were marked by limited success and ethical controversy, recent advances in genetic engineering, immunosuppression, and organ preservation have brought the field closer than ever to clinical reality.

In this episode of Behind the Knife, we are joined by Dr. Joshua Mezrich to explore the history, science, and future of xenotransplantation. Through a narrative lens, we trace the evolution of transplantation from its earliest experimental days to the modern era of gene-edited porcine organs, highlighting key breakthroughs, ethical challenges, and the pioneers who shaped the field. We also examine the current state of clinical trials and what xenotransplantation may mean for the future of organ availability and transplant practice.

Hosts
- Madeline Cloonan, MD PhD, General Surgery Resident, University of Nebraska Medical Center, @maddie_cloonan
- Joshua Mezrich, MD, Professor, University of Wisconsin School of Medicine and Public Health

Learning Objectives
By the end of this episode, listeners will be able to:
- Describe the historical evolution of xenotransplantation, including the primate and early porcine eras
- Explain the key immunologic and biologic barriers to xenotransplantation, including hyperacute rejection and the role of natural antibodies
- Summarize major scientific advances that enabled modern xenotransplantation, including cloning and CRISPR-based gene editing
- Discuss recent clinical experiences and ongoing trials of xenotransplantation in humans
- Evaluate the ethical considerations and societal implications of xenotransplantation
- Consider the potential role of xenotransplantation in addressing organ shortage and reshaping transplant eligibility and allocation

Check out Dr. Mezrich’s new book!
https://www.amazon.com/Every-Living-Creature-Xenotransplantation-Change-ebook/dp/B0FH14LF6K

***Fellowship Application Link: https://forms.gle/QSUrR2GWHDZ1MmWC6

***Surgical Instrument FlashCards: https://app.behindtheknife.org/premium/surgical-instrument-flashcards

Denne episoden er hentet fra en åpen RSS-feed og er ikke publisert av Podme. Den kan derfor inneholde annonser.

Episoder(500)

EPA Playbook: Small Bowel Obstruction

Join Drs. Georgoff, Burke, and Premkumar in this episode of EPA Playbook, where we tackle the evaluation and management of small bowel obstruction. Through a realistic series of scenarios, we walk ste...

6 Jul 24min

EPA Playbook: Inguinal Hernia

In this episode of EPA Playbook, Drs. Jason Bingham, Emma Burke, and Agnes Premkumar discuss the evaluation and management of inguinal hernias through a case-based approach that reinforces key EPA con...

5 Jul 21min

EPA Playbook: Perioperative Care of Critically Ill Patient

In this episode of EPA Playbook, Drs. Kevin Kniery, Emma Burke, and Agnes Premkumar discuss management of critically ill surgical patients, using case-based discussions to reinforce core principles of...

4 Jul 24min

EPA Playbook: Benign or Malignant Colon

Join Drs. Steele, Burke, & Premkumar in this episode of EPA Playbook, where we tackle a core general surgery EPA: the evaluation and management of benign and malignant colon disease. From common prese...

3 Jul 27min

Are EPAs Actually Working? An Honest Look at Competency-Based Surgical Training

Two years into the EPA era — are we actually training surgeons differently, or just checking new boxes? In this episode, Behind the Knife co-director and Duke Trauma Surgeon Dr. Patrick Georgoff and B...

2 Jul 37min

Intraoperative Cholangiography Guidelines: Routine, Selective, or Never?

In this episode, we use the recent SAGES guidelines to tackle one of the most common and controversial questions in general surgery. Through a case-based discussion, our experts review the evidence fo...

29 Jun 34min

Clinical Challenges in Hernia Surgery: Is Optimization Still Necessary for Hernia Surgery?

Join our Hernia Team for a review of the current controversy around preoperative optimization and the practical implications.Hosts: Dr. Maggie Bosley - @MBosleyMD Dr. Sean Orenstein - @OrensteinSean D...

25 Jun 34min

Rectal Cancer in the Young and Pregnant: Fertility and Management Considerations

As colorectal cancer rates rise among younger adults, surgeons are increasingly caring for patients with rectal cancer who are pregnant or hoping to preserve future fertility. With more individuals de...

22 Jun 27min