Dr. Florence Comite: The 5 Biomarkers Every Midlife Woman Must Test | #156

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I sat down with Dr. Florence Comite, the original gangster of precision medicine, who has been treating every patient as an "N of 1" for over 30 years. She pioneered Women's Health at Yale in 1992 and has spent her career proving that your genes are not your destiny. We go deep into what it actually takes to reverse biological aging, not slow it, reverse it.

What we cover:

- The five biomarkers that are suboptimal in nearly every patient, and why your doctor is probably not testing all of them.

- Why "normal" lab values are not the same as optimal, and how that gap is silently costing you your health.

- Why testosterone is the most underprescribed hormone in women's health, and what you lose without it.

- How epigenetics means your lifestyle is rewriting your genetic destiny every single day.

Why sleep, not exercise, is the foundation everything else is built on.

About Dr. Florence Comite:
Florence Comite, MD, physician-scientist, endocrinologist, and global authority on healthy longevity, is founder of the Comite Center for Precision Medicine & Healthy Longevity in New York, Palo Alto, and Miami Beach. A Yale School of Medicine graduate and faculty member for twenty-five years, Dr. Comite held triple appointments in Endocrinology (Internal Medicine and Pediatrics) and Reproductive Endocrinology (Gynecology and Andrology). As a clinical investigator, she developed research and patented therapies at the National Institutes of Health (NIH) and Yale. In 1992, she pioneered the nation's first center for women's health at Yale, redefining integrative care for women. Dr. Comite also founded the first physician-led artificial intelligence app. Trained on decades of her proprietary real-world research, it's a powerful personalized tool to help people optimize their healthspan.

Connect with Dr. Florence Comite:
Website: www.comitemd.com
Instagram: https://www.instagram.com/drflorencecomite/
LinkedIn: https://www.linkedin.com/in/drflorencecomite/
TikTok: https://www.tiktok.com/@drflorencecomite/

X (Twitter): https://x.com/FlorenceComite

📗 Invincible: Defy Your Genetic Destiny to Live Better, Longer by Dr. Florence Comite
This is the book for anyone who refuses to accept that decline is inevitable.

Preorder the book at your favorite online bookseller: https://www.theinvinciblebook.com/

Timestamps

00:00 Intro

01:46 You Are an N of 1

05:58 Hormones as Master Communicators

09:28 The 5 Biomarkers Everyone Gets Wrong

14:23 Normal vs. Optimal

18:27 What Wearing a CGM Will Teach You About Yourself

22:24 The Thrifty Gene Theory

27:29 Testosterone in Women

32:12 Birth Control Pills and Bone Loss

37:00 How Lifestyle Rewrites Your Genes

40:30 Intermittent Fasting and GLP-1s

43:14 Do Biological Age Tests Actually Work?

46:10 Sleep Is the Foundation

49:28 Making Precision Medicine for Everyone

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About Dr. Vonda Wright

Dr. Vonda Wright is an orthopedic sports surgeon and leading expert in women's health and longevity.

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