Methylphenidate Promotes a Frontoparietal-Dominant Brain State Improving Cognitive Performance: A Randomized Trial
The Journal Club29 Apr 2025

Methylphenidate Promotes a Frontoparietal-Dominant Brain State Improving Cognitive Performance: A Randomized Trial

Methylphenidate (MP) is primarily prescribed for attention-deficit/hyperactivity disorder, but it is also misused as a cognitive

enhancer by individuals seeking to improve cognitive performance. Using advanced brain imaging and behavioral tasks, this

study investigates how MP affects dopamine signaling, brain activity, and cognitive performance. Our results demonstrate

that MP promoted a frontoparietal-dominant brain state which linked to improved task performance and D1 receptor

availability. This research also introduces a multilevel neuroimaging approach to studying drug effects, offering a foundation

for tailoring interventions by predicting individual variations in responses to medicine.


Yan W, Demiral ŞB, Tomasi D, Zhang R, Manza P, Wang GJ, Volkow ND. Methylphenidate promotes a frontoparietal-dominant brain state improving cognitive performance: a randomized trial. J Neurosci. 2025 Mar 18

Denne episoden er hentet fra en åpen RSS-feed og er ikke publisert av Podme. Den kan derfor inneholde annonser.

Episoder(250)

The Science of Chocolate

The Science of Chocolate

Gopaulchan, D., Moore, C., Ali, N. et al. A defined microbial community reproduces attributes of fine flavour chocolate fermentation. Nat Microbiol (2025). https://doi-org.ccmain.ohionet.org/10.1038/s...

20 Aug 202520min

Molecular Mechanisms Underlying Fear Learning and Memory

Molecular Mechanisms Underlying Fear Learning and Memory

mWAKE in the Central Amygdala Regulates Fear Learning and MemoryJiali Xiong, Anuradha Mehta, Qiang Liu, Anna X. Luo, Pan P. Li, Patricia H. Janak, Mark N. WuJournal of Neuroscience 20 August 2025, e02...

20 Aug 202512min

Your Brain's Invisible Shield: How Anticipation Primes Your Immune System

Your Brain's Invisible Shield: How Anticipation Primes Your Immune System

Trabanelli, S., Akselrod, M., Fellrath, J. et al. Neural anticipation of virtual infection triggers an immune response. Nat Neurosci (2025). https://doi.org/10.1038/s41593-025-02008-y

11 Aug 202517min

Pancreas-Brain Feedback in Bipolar and Depression

Pancreas-Brain Feedback in Bipolar and Depression

Liu, YN., Wang, QW., She, XY. et al. A pancreas–hippocampus feedback mechanism regulates circadian changes in depression-related behaviors. Nat Neurosci (2025). https://doi.org/10.1038/s41593-025-0204...

11 Aug 202516min

AMPA Receptor Activity and Myelinated Axon Loss in Neuroinflammation

AMPA Receptor Activity and Myelinated Axon Loss in Neuroinflammation

Reduction of AMPA receptor activity on matureoligodendrocytes attenuates loss of myelinated axonsin autoimmune neuroinflammation

20 Jul 202513min

Targeting AMPA Receptors to Restore Synapses in Autoimmune Demyelination

Targeting AMPA Receptors to Restore Synapses in Autoimmune Demyelination

Mey GM, Evonuk KS, Shelestak J, Irfan M, Wolfe LM, Laye SE, Schafer DP, DeSilva TM. Inhibiting AMPA receptor signaling in oligodendrocytes rescues synapse loss in a model of autoimmune demyelination. ...

19 Jul 202513min

The use of behavioral test batteries: effects of training history

The use of behavioral test batteries: effects of training history

McIlwain KL, Merriweather MY, Yuva-Paylor LA, Paylor R. The use of behavioral test batteries: effects of training history. Physiol Behav. 2001 Aug;73(5):705-17.

1 Jul 202514min

Human CLOCK's Role in Cognitive Flexibility

Human CLOCK's Role in Cognitive Flexibility

Liu, Y., Fontenot, M.R., Kulkarni, A. et al. Human CLOCK enhances neocortical function. Nat Neurosci (2025)

30 Jun 202512min

Populært innen Vitenskap

fastlegen
tingenes-tilstand
romkapsel
rss-nysgjerrige-norge
liberal-halvtime
rekommandert
jss
villmarksliv
dekodet-2
abels-tarn
sinnsyn
vett-og-vitenskap-med-gaute-einevoll
fjellsportpodden
rss-overskuddsliv
rss-rekommandert
rss-paradigmepodden
tomprat-med-gunnar-tjomlid
diagnose
rss-inn-til-kjernen-med-sunniva-rose
nordnorsk-historie