PTN activity in quiescent neural stem cells mediates Shank3 overexpression-induced manic behavior
The Journal Club29 Apr 2025

PTN activity in quiescent neural stem cells mediates Shank3 overexpression-induced manic behavior

This study identifies excessive Pleiotrophin (PTN) released by dysregulated quiescent neural stem cells (qNSCs) as a key driver of manic-like behaviors in Shank3-overexpressing mice. Inhibiting PTN in qNSCs corrected abnormal neurogenesis and alleviated social deficits, suggesting PTN as a potential therapeutic target for mania.

Kim H, Cho B, Kim HK, Kang S, An S, Kwon D, Kim HY, Kim J. PTN activity in quiescent neural stem cells mediates Shank3 overexpression-induced manic behavior. Nat Commun. 2025 Mar 11

Denne episoden er hentet fra en åpen RSS-feed og er ikke publisert av Podme. Den kan derfor inneholde annonser.

Episoder(250)

The Science of Chocolate

The Science of Chocolate

Gopaulchan, D., Moore, C., Ali, N. et al. A defined microbial community reproduces attributes of fine flavour chocolate fermentation. Nat Microbiol (2025). https://doi-org.ccmain.ohionet.org/10.1038/s...

20 Aug 202520min

Molecular Mechanisms Underlying Fear Learning and Memory

Molecular Mechanisms Underlying Fear Learning and Memory

mWAKE in the Central Amygdala Regulates Fear Learning and MemoryJiali Xiong, Anuradha Mehta, Qiang Liu, Anna X. Luo, Pan P. Li, Patricia H. Janak, Mark N. WuJournal of Neuroscience 20 August 2025, e02...

20 Aug 202512min

Your Brain's Invisible Shield: How Anticipation Primes Your Immune System

Your Brain's Invisible Shield: How Anticipation Primes Your Immune System

Trabanelli, S., Akselrod, M., Fellrath, J. et al. Neural anticipation of virtual infection triggers an immune response. Nat Neurosci (2025). https://doi.org/10.1038/s41593-025-02008-y

11 Aug 202517min

Pancreas-Brain Feedback in Bipolar and Depression

Pancreas-Brain Feedback in Bipolar and Depression

Liu, YN., Wang, QW., She, XY. et al. A pancreas–hippocampus feedback mechanism regulates circadian changes in depression-related behaviors. Nat Neurosci (2025). https://doi.org/10.1038/s41593-025-0204...

11 Aug 202516min

AMPA Receptor Activity and Myelinated Axon Loss in Neuroinflammation

AMPA Receptor Activity and Myelinated Axon Loss in Neuroinflammation

Reduction of AMPA receptor activity on matureoligodendrocytes attenuates loss of myelinated axonsin autoimmune neuroinflammation

20 Jul 202513min

Targeting AMPA Receptors to Restore Synapses in Autoimmune Demyelination

Targeting AMPA Receptors to Restore Synapses in Autoimmune Demyelination

Mey GM, Evonuk KS, Shelestak J, Irfan M, Wolfe LM, Laye SE, Schafer DP, DeSilva TM. Inhibiting AMPA receptor signaling in oligodendrocytes rescues synapse loss in a model of autoimmune demyelination. ...

19 Jul 202513min

The use of behavioral test batteries: effects of training history

The use of behavioral test batteries: effects of training history

McIlwain KL, Merriweather MY, Yuva-Paylor LA, Paylor R. The use of behavioral test batteries: effects of training history. Physiol Behav. 2001 Aug;73(5):705-17.

1 Jul 202514min

Human CLOCK's Role in Cognitive Flexibility

Human CLOCK's Role in Cognitive Flexibility

Liu, Y., Fontenot, M.R., Kulkarni, A. et al. Human CLOCK enhances neocortical function. Nat Neurosci (2025)

30 Jun 202512min

Populært innen Vitenskap

fastlegen
tingenes-tilstand
romkapsel
rss-nysgjerrige-norge
liberal-halvtime
rekommandert
jss
villmarksliv
dekodet-2
abels-tarn
sinnsyn
vett-og-vitenskap-med-gaute-einevoll
fjellsportpodden
rss-overskuddsliv
rss-rekommandert
rss-paradigmepodden
tomprat-med-gunnar-tjomlid
diagnose
rss-inn-til-kjernen-med-sunniva-rose
nordnorsk-historie