FFP 625 | The Case for Progesterone in Perimenopause | Dr. Jerilynn Prior

In this episode, Lisa welcomes back Dr. Jerilynn Prior, endocrinologist, UBC Professor Emerita, and founder of the Centre for Menstrual Cycle and Ovulation Research (CeMCOR), for a thought-provoking conversation that challenges mainstream narratives about perimenopause and hormone therapy. Dr. Prior shares her research-backed perspective on why perimenopause is often characterized by erratically high estrogen rather than low estrogen, and how this physiological reality reshapes the conversation around symptoms like night sweats, sleep disturbances, heavy flow, and sore breasts. She discusses her randomized controlled trial demonstrating that progesterone is effective for night sweats and sleep in perimenopausal women, and explains why approximately 30% of perimenopausal women experience symptoms severe enough to warrant treatment. Lisa and Dr. Prior also explore findings from the Women's Health Initiative, the difference between treating symptomatic women and prescribing hormones preventively, and why the cultural framing of menopause as a deficiency disease misrepresents what is, for most women, a normal life transition. Tune in as Dr. Prior shares decades of research on the menstrual cycle, ovulation, and the often-overlooked role of progesterone in women's health across the lifespan.

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