Association of Changes in Activity Patterns With Brain Atrophy and Disability Progression in People With MS

Dr. Alex Menze and Dr. Kathryn C. Fitzgerald discuss using accelerometry to detect subtle, longitudinal changes in disability in people with multiple sclerosis and how these changes relate to brain atrophy and disability progression.

Show citation:

Fitzgerald KC, Sanjayan M, Dewey BE, et al. Association of Changes in Activity Patterns With Brain Atrophy and Disability Progression in People With Multiple Sclerosis. Neurology. 2026;106(7):e214678. doi:10.1212/WNL.0000000000214678

Show transcript:

Dr. Alexander Menze:

Hi, this is Alexander Menze. I just finished interviewing Kate Fitzgerald for the Neurology Podcast. For today's Neurology Minute, Kate, I'm hoping you can tell us the main points of your paper.

Dr. Kathryn C. Fitzgerald:

So we followed 238 people with MS who are 40 or older for over three years and they wore risk-worn accelerometers roughly every three months and had regular clinical assessments and brain MRI. And what we found was that changes in activity patterns over time at the individual level were associated with subsequent changes in disability worsening and brain volume loss, particularly in the deep gray matter and thalamus.

Dr. Alexander Menze:

Thank you very much. Be sure to download this week's podcast to hear our full interview.

Denne episoden er hentet fra en åpen RSS-feed og er ikke publisert av Podme. Den kan derfor inneholde annonser.

Episoder(2007)

Comparison of the Efficacy and Safety of Myasthenia Gravis Treatments - Part 1

In the first installment of this series, Dr. Aaron Zelikovich and Dr. Bhaskar Roy discuss how emerging treatments for myasthenia gravis compare to one another. Show citation: McLaren NP, Rosati M, Z...

4 Sep 1min

National Trends in Medicare Charges and Reimbursement for Inpatient Neurologic Care

Dr. Jason Crowell and Ka-Ho Wong discuss national trends in Medicare reimbursement for inpatient neurologic care. Show citation: Wong KH, Castillo M, King J, et al. National Trends in Medicare Charg...

3 Sep 2min

Updates in Neuroinfectious Disease - Part 3

In the third episode of this series, Dr. Paul Crane and Dr. Prashanth Ramachandran discuss HSV encephalitis and dexamethasone.

2 Sep 5min

Updates in Neuroinfectious Disease - Part 2

In part two of this series, Dr. Paul Crane and Dr. Prashanth Ramachandran discuss pegivirus-associated encephalomyelitis.

1 Sep 5min

Updates in Neuroinfectious Disease - Part 1

In part one of this series, Dr. Paul Crane and Dr. Prashanth Ramachandran discuss acute necrotizing encephalopathy.

31 Aug 4min

2026 Alzheimer's Association International Conference - Part 1

In part one of this series, Drs. Greg Cooper, Trey Bateman, and Gregg Day discussed key takeaways from the 2026 Alzheimer's Association International Conference, focusing on blood-based biomarkers, an...

27 Aug 1min

Recap from the 2026 AAN Autoimmune Neurology Conference

Dr. Justin Abbatemarco recaps a presentation on Hashimoto encephalopathy from the AAN Autoimmune Neurology Conference. Show citation: Valencia-Sanchez C, Pittock SJ, Mead-Harvey C, et al. Brain d...

26 Aug 2min