Biohacking Beauty: The Anti-Aging Skincare Podcast27 Mai

The Overlooked Side of Autophagy Causing Aging - Part 2

The melanocytes giving pigment to your skin right now might be older than your car. They have been sitting in your dermis for decades, and unlike the cells on your skin's surface, they do not get replaced. They have to keep themselves clean which happens through autophagy.

In Part 2 of our autophagy deep dive, we get specific about how skin handles autophagy differently from other parts of the body. We unpack why long-lived cells like fibroblasts and melanocytes depend on this cleanup process, what happens when it fails, and how it ties directly to gray hair, hyperpigmentation, sagging skin, and that brownish dullness no serum seems to fix.

We also introduce one of the most overlooked players in this entire conversation, and explain why we believe it is the next NAD. If you want to understand what is actually happening underneath your skin as it ages, and what tools we have to intervene at the cellular level, this episode is for you.

What's Discussed:

(01:06) Why skin needs autophagy more than almost any other organ
(03:07) The cells on your face that may be older than your car
(04:25) The 2013 paper that linked autophagy failure to dermatitis
(08:44) Zombie mitochondria and why photo-aged skin makes bad collagen
(12:25) Senescent cells, SASP, and how a few bad cells poison the dermis
(18:38) The 2019 Drexel rapamycin trial that proved this works in humans
(23:22) The 2024 spermidine study that changes how we think about autophagy
(29:51) Why your skin barrier collapses without this one molecule

Resources Mentioned:

Biohacking Beauty Podcast with Dr. Scott Sherr: Stress & Light on Your Skin Are Aging Your Entire Body Podcast/dr-scott-sherr-stress-light-on-your-skin-are-aging/

2024 Study on endogenous spermidine as essential for rapamycin-induced autophagy and longevity: pubmed.ncbi.nlm.nih.gov/39212197/

Young Goose Companion Booklet: younggoose.com/pages/autophagy-skin-activate-your-bodys-anti-aging-system

Find more from Young Goose:

Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.com
Instagram: @young_goose_skincare

Denne episoden er hentet fra en åpen RSS-feed og er ikke publisert av Podme. Den kan derfor inneholde annonser.

Episoder(270)

271. Dr. Mamina Turegano: What Your Skin Reveals About Your Health, Aging & Hormones

Most of us assume that if something serious was happening inside our body, we would know. We would feel sick. Something would hurt. A blood test would catch it. But some health problems can develop qu...

16 Sep 57min

270. Your Most-Asked Skincare Questions, Answered With Science

Social media has made skincare information easier to access than ever. One video can convince you to increase your retinol. Another influencer can tell you an ingredient is “toxic.” Then someone else ...

9 Sep 33min

269. Cynthia Thurlow: What Midlife Gut Changes Have To Do With Your Skin

When your skin starts changing in midlife, it is easy to assume the products that used to work suddenly stopped working. And when changing the routine does not fix it, hormones usually get the blame.B...

2 Sep 52min

268. 10 Habits for Younger Skin That Have Nothing To Do With Skincare

Everyone wants skin that looks brighter, firmer, smoother, and healthier for longer.But sometimes the thing holding your skin back is not the serum you forgot to buy. It is the blood sugar spike you k...

26 Aug 19min

267. Dr. Amie Hornaman: The Thyroid Mistake That Keeps Women From Getting Answers

Thyroid dysfunction is often treated like it is easy to rule out. You ask for labs, your doctor checks TSH, and if that one marker is not flagged, you are told your thyroid is fine.But what if that is...

19 Aug 55min

266. Q&A: Your Questions Answered on Exosome Skincare (Everything You Need To Know Before You Try)

Exosomes have become one of the most talked-about ingredients in advanced skincare, but the conversation around them can get confusing fast. Some people hear “cellular messaging” and worry about DNA. ...

12 Aug 39min

265. Anastasia (Beauty Fascia) Part 2: The Hidden Cost of Fillers, Botox, and Skin Tightening Devices

A lot of beauty treatments are sold around the result people want most: tighter skin, fewer lines, more volume, and a face that looks refreshed without going under the knife.And because these treatmen...

5 Aug 53min

264. Anastasia (Beauty Fascia) Part 1: Do Red Light Masks, Gua Sha, and Facial Devices Actually Work?

Red light masks, facial sculpting devices, gua sha tools, and at-home lifting treatments are everywhere. And when a tool promises less puffiness, a sharper jawline, or younger-looking skin, it is easy...

29 Jul 37min