234 | Tobias Warnecke on Cellular Structure and Evolution

234 | Tobias Warnecke on Cellular Structure and Evolution

Eukaryotic cells manage to pull off a number of remarkable feats. One is packing quite a long DNA molecule, with potentially billions of base pairs, into a tiny central nucleus. A key role is played by histones, proteins that provide scaffolding for DNA to wrap around. Histones also appear in archaea (one of the other domains of life), but until recently there wasn't evidence for them in bacteria (the final of the three domains). Todays guest, Tobias Warnecke, is an author on a recent paper that claims to provide such evidence. We discuss this new result, as well as background questions of how cells evolved and what their current structure can teach us about their histories.

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Tobias Warnecke received his Ph.D. in biology from the University of Bath. He is currently a Programme Leader and MRC Investigator at the London Institute of Medical Sciences. He is a co-author on A. Hochner et al. (2023), "Histone-Organized Chromatin in Bacteria."


Episoder(418)

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156 | Catherine D'Ignazio on Data, Objectivity, and Bias

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155 | Stephen Wolfram on Computation, Hypergraphs, and Fundamental Physics

155 | Stephen Wolfram on Computation, Hypergraphs, and Fundamental Physics

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AMA | July 2021

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154 | Reza Aslan on Religion, Metaphor, and Meaning

154 | Reza Aslan on Religion, Metaphor, and Meaning

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153 | John Preskill on Quantum Computers and What They're Good For

153 | John Preskill on Quantum Computers and What They're Good For

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152 | Charis Kubrin on Criminology, Incarceration, and Hip-Hop

152 | Charis Kubrin on Criminology, Incarceration, and Hip-Hop

It's all well and good to talk abstractly about morality and justice, but at some point you have to sit down and figure out what to do about people who break the rules. In our modern legal system, mos...

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151 | Jordan Ellenberg on the Mathematics of Political Boundaries

151 | Jordan Ellenberg on the Mathematics of Political Boundaries

Any system in which politicians represent geographical districts with boundaries chosen by the politicians themselves is vulnerable to gerrymandering: carving up districts to increase the amount of se...

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AMA | June 2021

AMA | June 2021

Welcome to the June 2021 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). I take the large number of questi...

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