234 | Tobias Warnecke on Cellular Structure and Evolution

234 | Tobias Warnecke on Cellular Structure and Evolution

Eukaryotic cells manage to pull off a number of remarkable feats. One is packing quite a long DNA molecule, with potentially billions of base pairs, into a tiny central nucleus. A key role is played by histones, proteins that provide scaffolding for DNA to wrap around. Histones also appear in archaea (one of the other domains of life), but until recently there wasn't evidence for them in bacteria (the final of the three domains). Todays guest, Tobias Warnecke, is an author on a recent paper that claims to provide such evidence. We discuss this new result, as well as background questions of how cells evolved and what their current structure can teach us about their histories.

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Tobias Warnecke received his Ph.D. in biology from the University of Bath. He is currently a Programme Leader and MRC Investigator at the London Institute of Medical Sciences. He is a co-author on A. Hochner et al. (2023), "Histone-Organized Chromatin in Bacteria."


Episoder(412)

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Bonus | AIP Oral History Interview

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132 | Michael Levin on Growth, Form, Information, and the Self

132 | Michael Levin on Growth, Form, Information, and the Self

As a semi-outsider, it's fun for me to watch as a new era dawns in biology: one that adds ideas from physics, big data, computer science, and information theory to the usual biological toolkit. One of...

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131 | Avi Loeb on Taking Aliens Seriously

131 | Avi Loeb on Taking Aliens Seriously

The possible existence of technologically advanced extraterrestrial civilizations — not just alien microbes, but cultures as advanced (or much more) than our own — is one of the most provocative quest...

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130 | Frank Wilczek on the Present and Future of Fundamental Physics

130 | Frank Wilczek on the Present and Future of Fundamental Physics

What is the world made of? How does it behave? These questions, aimed at the most basic level of reality, are the subject of fundamental physics. What counts as fundamental is somewhat contestable, bu...

18 Jan 20211h 16min

129 | Solo: Democracy in America

129 | Solo: Democracy in America

The first full week of 2021 has been action-packed for those of us in the United States of America, for reasons you're probably aware of, including a riotous mob storming the US Capitol. The situation...

11 Jan 20211h 43min

128 | Joseph Henrich on the Weirdness of the West

128 | Joseph Henrich on the Weirdness of the West

We all know stereotypes about people from different countries; but we also recognize that there really are broad cultural differences between people who grow up in different societies. This raises a c...

4 Jan 20211h 27min

Holiday Message 2020 | The Screwy Universe

Holiday Message 2020 | The Screwy Universe

Welcome to the third annual Mindscape Holiday Message! Just a chance for me to be a little more chatty and informal than usual, although as it turned out this isn't all that different from a conventio...

21 Des 20201h 31min

127 | Erich Jarvis on Language, Birds, and People

127 | Erich Jarvis on Language, Birds, and People

Many characteristics go into making human beings special — brain size, opposable thumbs, etc. Surely one of the most important is language, and in particular the ability to learn new sounds and use th...

14 Des 20201h 15min

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