234 | Tobias Warnecke on Cellular Structure and Evolution

234 | Tobias Warnecke on Cellular Structure and Evolution

Eukaryotic cells manage to pull off a number of remarkable feats. One is packing quite a long DNA molecule, with potentially billions of base pairs, into a tiny central nucleus. A key role is played by histones, proteins that provide scaffolding for DNA to wrap around. Histones also appear in archaea (one of the other domains of life), but until recently there wasn't evidence for them in bacteria (the final of the three domains). Todays guest, Tobias Warnecke, is an author on a recent paper that claims to provide such evidence. We discuss this new result, as well as background questions of how cells evolved and what their current structure can teach us about their histories.

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Tobias Warnecke received his Ph.D. in biology from the University of Bath. He is currently a Programme Leader and MRC Investigator at the London Institute of Medical Sciences. He is a co-author on A. Hochner et al. (2023), "Histone-Organized Chromatin in Bacteria."


Episoder(423)

84 | Suresh Naidu on Capitalism, Monopsony, and Inequality

84 | Suresh Naidu on Capitalism, Monopsony, and Inequality

Nations generally want their economies to be rich, robust, and growing. But it's also important to person to ensure that wealth doesn't flow only to a few people, but rather that as many people as pos...

17 Feb 20201h 26min

83 | Kwame Anthony Appiah on Identity, Stories, and Cosmopolitanism

83 | Kwame Anthony Appiah on Identity, Stories, and Cosmopolitanism

The Greek statesman Demosthenes is credited with saying "I am a citizen of the world," and the idea that we should take a cosmopolitan view of our common humanity is a compelling one. Not everyone agr...

10 Feb 20201h 38min

82 | Robin Carhart-Harris on Psychedelics and the Brain

82 | Robin Carhart-Harris on Psychedelics and the Brain

The Convention on Psychotropic Substances was a 1971 United Nations treaty that placed strong restrictions on the use of psychedelic drugs — not only on personal use, but medical and scientific resear...

3 Feb 20201h 17min

81 | Ezra Klein on Politics, Polarization, and Identity

81 | Ezra Klein on Politics, Polarization, and Identity

People have always disagreed about politics, passionately and sometimes even violently. But in certain historical moments these disagreements were distributed without strong correlations, so that any ...

27 Jan 20201h 21min

80 | Jenann Ismael on Connecting Physics to the World of Experience

80 | Jenann Ismael on Connecting Physics to the World of Experience

Physics is simple; people are complicated. But even people are ultimately physical systems, made of particles and forces that follow the rules of the Core Theory. How do we bridge the gap from one kin...

20 Jan 20201h 26min

79 | Sara Imari Walker on Information and the Origin of Life

79 | Sara Imari Walker on Information and the Origin of Life

We are all alive, but "life" is something we struggle to understand. How do we distinguish a "living organism" from an emergent dynamical system like a hurricane, or a resource-consuming chemical reac...

13 Jan 20201h 23min

78 | Daniel Dennett on Minds, Patterns, and the Scientific Image

78 | Daniel Dennett on Minds, Patterns, and the Scientific Image

Wilfrid Sellars described the task of philosophy as explaining how things, in the broadest sense of term, hang together, in the broadest sense of the term. (Substitute "exploring" for "explaining" and...

6 Jan 20202h 1min

Holiday Message 2019: On Publishing Books

Holiday Message 2019: On Publishing Books

Welcome to the second annual Mindscape Holiday Message! No substantive content or deep ideas, just me talking a bit about the state of the podcast and what's on my mind. Since the big event for me in ...

22 Des 20191h 6min

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