Dr. Colleen Cutcliffe, PhD: Natural GLP-1 Production, Fiber Deficiency, Akkermansia and the Gut Microbiome Connection

Dr. Colleen Cutcliffe, PhD: Natural GLP-1 Production, Fiber Deficiency, Akkermansia and the Gut Microbiome Connection

Most people think of the gut as a digestive organ. It is not. It is the upstream controller of your metabolism, immune function, brain health, skin, and hormones and almost everyone is running it on a depleted, misfed microbiome without knowing it.

Dr. Colleen Cutcliffe, PhD is the co-founder and CEO of Pendulum Therapeutics, holds a PhD in biochemistry from Johns Hopkins, and spent over 15 years in pharma and biotech before pioneering next-generation probiotic science. Her team was the first in the world to manufacture Akkermansia, a strain found at high levels in virtually every centenarian population studied and depleted in almost every major chronic disease.

What makes this conversation different from most gut health discussions is the level of scientific rigor behind it. This is not wellness theory. This is published research, clinical data, and a decade of actually building the science from the ground up.

Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.

https://kayla-barnes-lentz.circle.so/checkout/become-a-member

In this conversation we explore:

  • How your gut produces its own GLP-1 naturally and why synthetic versions may blunt that system over time

  • Why Akkermansia is elevated in centenarians and depleted across virtually every chronic disease

  • The fiber gap: 95% of people are under-threshold and it is driving metabolic and colon health decline

  • What early antibiotic use does to the microbiome and how to rebuild at any age

  • Why soap may be fueling the allergy and asthma epidemic by stripping the skin's protective barrier

  • How butyrate links gut health, colon cancer risk, and natural GLP-1 production

  • Why most probiotics on Amazon do not contain what the label claims

Connect with Kayla:

Instagram: https://www.instagram.com/kaylabarnes/

TikTok: https://www.tiktok.com/@femalelongevity

Twitter:https://x.com/femalelongevity

Website:https://www.kaylabarnes.com/

Spotify: https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054

Apple: https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227

Follow Her Female Protocol: https://www.protocol.kaylabarnes.com

Learn more about Dr Coleen

Instagram: https://www.instagram.com/drcolleencutcliffe/

Pendulum Life Instagram: https://www.instagram.com/pendulumlifeco/

Website: https://pendulumlife.com/


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Episoder(174)

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Dr. Saranya Wyles, MD, PhD: Skin Aging, Senescent Cells, Botox and Regenerative Dermatology

Most anti-aging skincare focuses on wrinkles after they appear. Skin longevity starts much earlier, with the biology that determines how well skin repairs itself, maintains collagen, responds to hormo...

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Our First Pregnancy: How We Got Pregnant, The Changes and the Questions

Our First Pregnancy: How We Got Pregnant, The Changes and the Questions

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Dr. Kutluk Oktay, MD, PhD: Ovarian Aging, Fertility Preservation, and Delaying Menopause

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Menopause does not begin when periods stop. Ovarian reserve and egg quality have been declining for decades, and that decline accelerates for many women in their late 30s.I sat down with Kutluk Oktay,...

8 Okt 58min

Carolina Reis Oliveira, PhD: Senescent Cells, Retinol Myths, and the Skin Barrier Body Connection

Carolina Reis Oliveira, PhD: Senescent Cells, Retinol Myths, and the Skin Barrier Body Connection

Most skincare is designed to improve how aging looks. But can it change what is happening inside the skin itself?In this conversation, I sit down with Carolina Reis Oliveira, PhD, co-founder and CEO o...

24 Sep 1h

Dr. Abud Bakri, MD: Thymus Health, Circadian Biology, and the Truth About Peptides

Dr. Abud Bakri, MD: Thymus Health, Circadian Biology, and the Truth About Peptides

Most longevity conversations focus on the brain, heart, muscle, and metabolism. Far less attention goes to the thymus, an immune organ that starts shrinking almost as soon as puberty ends, and new res...

17 Sep 1h 7min

Dr. Will Cole: How to Heal Your Cells, Leaky Gut, Light Exposure, and Why Your Gut Sets the Pace To Aging

Dr. Will Cole: How to Heal Your Cells, Leaky Gut, Light Exposure, and Why Your Gut Sets the Pace To Aging

We talk about aging like it happens to a whole person at once. It doesn't. It happens organ by organ, at different speeds, and most people never find out which part of them is running ahead until some...

10 Sep 1h

Dr. Tania Dempsey, MD: Mast Cell Activation Syndrome, PMOS, and the Hidden Cause of Women's Chronic Symptoms

Dr. Tania Dempsey, MD: Mast Cell Activation Syndrome, PMOS, and the Hidden Cause of Women's Chronic Symptoms

Most women who deal with unexplained allergies, stubborn inflammation, heavy periods or a PMOS (formerly PCOS) diagnosis are never told to look at the same underlying cause: an immune cell most doctor...

3 Sep 1h 17min

Dr. Margie Davenport, PhD: Exercise in Pregnancy, the 140 BPM Myth, and Why Pregnancy Complications Predict Heart Disease

Dr. Margie Davenport, PhD: Exercise in Pregnancy, the 140 BPM Myth, and Why Pregnancy Complications Predict Heart Disease

Pregnancy has long been treated as a season to slow down and play it safe. The data tells a different story, and it starts with a number most women were taught to fear.Dr. Margie Davenport, PhD, is an...

27 Aug 59min

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