Season 1.  Episode 10.  Unscripted with Ed Addison

Season 1. Episode 10. Unscripted with Ed Addison

Ed Addison took his first AI course at MIT in 1985 and has spent the four decades since building through every wave of the field, from brittle rule-based expert systems in the 80s, to neural nets in the 90s, to the deep learning breakthrough of 2006, to the generative AI and transformer architectures that produced today's large language models.

He's founded five AI companies with three exits, most of it in the notoriously difficult world of AI drug discovery, where he argues the algorithms getting all the attention aren't actually the valuable asset: the data is, and Big Pharma still owns most of it. In this conversation with Jeff Pedowitz, Addison lays out why no AI-discovered drug has made it through FDA approval yet, why failure rate rather than speed or cost is the only number that will prove the technology works, and why he believes the AI industry has a financial bubble but not a scientific one.

The conversation closes with the story behind his "accidental novel," Probability of Doom, written with AI as a collaborator after a family road trip conversation, and now used in his own classroom to teach engineers what can go wrong when humans, humanoids, and multi-agent systems start operating side by side.

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Episoder(19)

Season 1.  Episode 19.  Unscripted with Matthew Guggemos

Season 1. Episode 19. Unscripted with Matthew Guggemos

Matthew Guggemos spent more than 20 years as a speech-language pathologist teaching children to communicate — kids for whom language doesn't come free — and now builds AI at scale as CTO of iTherapy, ...

8 Aug 52min

Season 1.  Episode 18.  Unscripted with Camberley Bates

Season 1. Episode 18. Unscripted with Camberley Bates

Camberley Bates has spent 30-plus years as one of enterprise technology's most respected independent analysts, paid to cut through vendor hype and tell executives what's real. On this episode of Unscr...

27 Jul 46min

Season 1.  Episode 17.  Unscripted with Russ Wilcox

Season 1. Episode 17. Unscripted with Russ Wilcox

Russ Wilcox, CEO of ArtifexAI, went from a broken sewer decision in his Cape Cod hometown to advising the Pentagon and State Department on the US-China AI race. In this episode of Unscripted, he tells...

27 Jul 52min

Season 1.  Ep[isode 16.  Unscripted with Keith Pijanowski

Season 1. Ep[isode 16. Unscripted with Keith Pijanowski

Every impressive AI demo sits on an enormous, expensive, and very unglamorous foundation of data. Keith Pijanowski is one of the people who built it. After a decade-plus at Microsoft (where he helped ...

22 Jul 45min

Season 1.  Episode 15.  Unscripted with Klas Nilsson

Season 1. Episode 15. Unscripted with Klas Nilsson

Everyone is promising humanoid robots in every home and factory. Klas Nilsson has spent 40 years on the part that turns out to be hard. The Cognibotics founder, who built one of the first digital robo...

20 Jul 45min

Season 1.  Episode 14.  Unscripted with Lena Smart

Season 1. Episode 14. Unscripted with Lena Smart

Lena Smart has spent 30 years securing the systems we genuinely cannot afford to have fail — the power grid, financial markets, and as longtime CISO at MongoDB, one of the most widely used databases o...

12 Jul 33min

Season 1.  Episode 13.  Unscripted with Sarah Chardonnens

Season 1. Episode 13. Unscripted with Sarah Chardonnens

Dr. Sarah Chardonnens is a professor at the University of Freiburg with a PhD in the science of learning, and in this conversation with Jeff Pedowitz she takes on the question everyone has an opinion ...

10 Jul 36min

Season 1.  Episode 12.  Unscripted with Juergen Weichenberger

Season 1. Episode 12. Unscripted with Juergen Weichenberger

Juergen Weichenberger has been building AI since the 1990s, well before it became a mainstream conversation, in domains where the cost of being wrong isn't a typo, it's a shutdown: factories, energy g...

10 Jul 34min

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