Why You Feel Older Than Your Labs Say You Are with Dr. Will Cole | E224

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Why do some people feel exhausted, mentally foggy, metabolically unwell, or simply older than they should even when their routine laboratory results are considered “normal”?

That question is at the heart of this episode of The Empowering Neurologist, featuring functional medicine practitioner Dr. Will Cole, coauthor with Dr. Josh Axe of Heal Your Cells: Reversing the Irreversible.

Dr. Cole and Dr. Perlmutter explore the idea that long before disease becomes obvious, dysfunction may already be developing at the cellular level. This concept takes on particular importance when we consider the brain, which accounts for only about 2% of body weight but consumes roughly 20% of the body's energy at rest.

The conversation examines how seemingly separate factors including metabolic dysfunction, chronic inflammation, poor sleep, environmental exposures, physical inactivity, and prolonged psychological stress can converge on the same cellular systems and ultimately influence brain health.

00:00 — Why Your Cells May Be Aging Before You Feel It

03:44 — Meet Dr. Will Cole

04:50 — What Is Cellular Dysfunction?

09:25 — Why Healthy People Can Still Develop Disease10:32 — The Environmental Factors Affecting Cellular Health

15:47 — Why Mitochondria Are Central to Health

16:37 — How Mitochondrial Dysfunction Drives Inflammation

19:57 — How Much of Aging Can We Actually Change?

20:47 — The Connection Between Mitochondria and Insulin Resistance

25:43 — Mitochondria, Microglia, and Brain Inflammation

29:28 — Why There Is No One-Size-Fits-All Diet

32:03 — Training Your Cells to Become More Resilient

32:46 — What Are “Adversity Mimetics”?

35:51 — Why Intracellular Health Matters

36:32 — Why Conventional Medicine May Be Missing Cellular Dysfunction

37:58 — What Do We Really Know About Peptides?

40:16 — Is Ozone Therapy Worth Considering?

42:30 — Ozone and the Science of Cellular Resilience

43:41 — What Is Therapeutic Plasma Exchange?

45:38 — Who Might Benefit From Plasma Exchange?

46:45 — The Everyday Habits That Support Cellular Health

51:35 — Your Cells Are Responding to the Choices You Make

Dr. Will Cole is a leading functional medicine expert specializing in thyroid health, autoimmune conditions, hormonal imbalances, digestive disorders, and brain health. He is the host of The Art of Being Well podcast and a New York Times bestselling author of Intuitive Fasting, Ketotarian, The Inflammation Spectrum, and Gut Feelings.

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Connect with Dr. Will Cole

Website: https://drwillcole.com

Instagram: https://www.instagram.com/drwillcole

LinkedIn: https://www.linkedin.com/in/drwillcole

Facebook: https://www.facebook.com/doctorwillcole

Podcast: https://open.spotify.com/show/6z1lJ5dfKNHwGGQPOFTc7E

Apple Podcasts: https://podcasts.apple.com/us/podcast/the-art-of-being-well/id1539535133

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Connect with Dr. David Perlmutter, MD

Website: https://www.drperlmutter.com/

Instagram: https://www.instagram.com/davidperlmutter/

Facebook: https://www.facebook.com/DavidPerlmutterMD/

YouTube: https://www.youtube.com/@DavidPerlmutterMD

X (Twitter): https://x.com/DavidPerlmutter

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