What a 1 mm Worm Can Teach Us About Diabetic Foot Ulcers

What a 1 mm Worm Can Teach Us About Diabetic Foot Ulcers

Dr. G explores how the tiny nematode C. elegans helps researchers study key processes related to diabetic foot ulcers, including wound detection, calcium signaling, cytoskeletal remodeling, mitochondrial reactive oxygen species, innate immune responses, and bacterial virulence.

While the worm cannot reproduce the full complexity of human diabetic foot disease, its transparency and genetic tractability make it a powerful early-stage model to identify pathways and test hypotheses that could inform future treatments.

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Episoder(374)

Forgotten Infection Friday: The Case of Erysipelothrix

Forgotten Infection Friday: The Case of Erysipelothrix

This episode explains Erysipelothrix rhusiopathiae, an animal-associated bacterium that can enter through minor skin breaks—often from fish, meat, or livestock exposure—and cause a localized lesion ca...

5 Sep 41min

When a Toe Is More Than Tissue: The Ethics of Diabetic Foot Consent

When a Toe Is More Than Tissue: The Ethics of Diabetic Foot Consent

Dr. G explains why informed consent in diabetic foot care is more than paperwork: it’s a time-sensitive conversation about capacity, risks, alternatives, and what happens if treatment is delayed. The ...

3 Sep 18min

Applying Newton’s Laws to Diabetic Foot Ulcers

Applying Newton’s Laws to Diabetic Foot Ulcers

In this episode Dr. G explains how Newton’s laws of motion illuminate why some diabetic foot ulcers heal and others recur. He connects concepts like force, pressure, shear, and ground reaction forces ...

2 Sep 41min

LIMBWatch Series: Dr. Jared Adams MD,PhD : Your Story Could Save a Limb: Inside the New Diabetic Foot Ulcer Patient Registry STEADY

LIMBWatch Series: Dr. Jared Adams MD,PhD : Your Story Could Save a Limb: Inside the New Diabetic Foot Ulcer Patient Registry STEADY

Your Story Could Save a Limb: Inside the New Diabetic Foot Ulcer Patient Registry What if the most important piece of diabetic foot ulcer research isn’t another clinical endpoint—but the patient’s sto...

31 Aug 49min

LIMBWatch Series: Dr. Sukoff, Dr. Hanley & Dr. Warren -     LIMBWatch: From Chronic Wound to Limb Preservation — The Science Behind Lavior

LIMBWatch Series: Dr. Sukoff, Dr. Hanley & Dr. Warren - LIMBWatch: From Chronic Wound to Limb Preservation — The Science Behind Lavior

Episode Summary In this episode of LIMBWatch, we go beyond the wound itself to explore the science, clinical challenges, and innovations shaping the future of limb preservation. We are joined by the t...

24 Aug 41min

Copper: A  Surprising Possible Ally in Diabetic Foot Ulcer Healing

Copper: A Surprising Possible Ally in Diabetic Foot Ulcer Healing

In this episode of Diabetic Fit Files Dr. G explores how the trace element copper affects diabetic foot ulcers at the cellular and molecular level. Topics include copper's roles in angiogenesis, colla...

23 Aug 27min

Reflexes, Tuning Forks & Monofilaments: Inside the Diabetic Foot Exam

Reflexes, Tuning Forks & Monofilaments: Inside the Diabetic Foot Exam

This episode breaks down the neurological exam of the diabetic foot, explaining reflexes, vibration testing, monofilament assessment, proprioception, pinprick and temperature testing, and the autonomi...

22 Aug 27min

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