GLP-1 Drugs... Are They Destroying Muscle? — What Semaglutide, Tirzepatide & Retatrutide Data Actually Shows

GLP-1 Drugs... Are They Destroying Muscle? — What Semaglutide, Tirzepatide & Retatrutide Data Actually Shows

A clinical deep dive into the muscle loss problem on GLP-1 medications. Semaglutide, tirzepatide, and the investigational triple agonist retatrutide all produce remarkable weight loss — but clinical trial data shows that a significant fraction of that loss is lean body mass, not fat. This episode covers the mechanism behind GLP-1-induced muscle wasting, the body composition data from STEP 1 and SURMOUNT trials, who carries the highest risk, and where the next generation of obesity pharmacology — bimagrumab combinations, pemvidutide, and retatrutide's glucagon receptor pathway — is trying to solve the problem. For clinicians, patients, and anyone paying attention to where obesity medicine is actually going.

This podcast is for informational purposes only and is not medical advice.

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Episoder(49)

SNAP-8: Is "Botox in a Bottle" Real?

SNAP-8: Is "Botox in a Bottle" Real?

SNAP-8 is a synthetic cosmetic octapeptide marketed for expression lines and frequently called "Botox in a bottle." John Garrett, RN, breaks down the SNAP-25 and SNARE-complex mechanism, the differenc...

9 Sep 14min

GLP-1 Microdosing: Smart Strategy or the Next Wellness Fad?

GLP-1 Microdosing: Smart Strategy or the Next Wellness Fad?

Visit peptidesexplained.info for more info and resources For more info on research peptides check out PeptidesExplained.info/OfflinePeptides or email John at john@peptidesexplained.info What exactly i...

7 Sep 23min

Thymalin vs Thymogen: Can Thymus Peptides Reverse Immune Aging?

Thymalin vs Thymogen: Can Thymus Peptides Reverse Immune Aging?

Can a peptide reverse age-related immune decline? Thymalin and Thymogen are often discussed together, but one is a complex calf-thymus extract and the other is the defined dipeptide Glu-Trp. John Garr...

2 Sep 15min

What Is Pinealon? Brain Aging, Neuroprotection, and the Evidence

What Is Pinealon? Brain Aging, Neuroprotection, and the Evidence

Check out The Peptide App here: thepeptide.app/explained What is Pinealon, and does this three-amino-acid peptide really protect the aging brain? Pinealon—also called EDR or Glu-Asp-Arg—is a synthetic...

31 Aug 22min

Khavinson Peptide Bioregulators: What Do They Actually Do?

Khavinson Peptide Bioregulators: What Do They Actually Do?

What are Khavinson peptide bioregulators, and what do they actually do? John Garrett examines the Russian research tradition behind organ-derived peptide complexes and synthetic ultrashort peptides. T...

30 Aug 19min

Did Your GLP-1 Stop Working? Appetite, Receptors and Weight-Loss Plateaus

Did Your GLP-1 Stop Working? Appetite, Receptors and Weight-Loss Plateaus

Does a weight-loss plateau mean your GLP-1 receptors have become desensitized? John separates cellular receptor biology from whole-body weight regulation and compares semaglutide, tirzepatide, and inv...

30 Aug 21min

Should You Be Using Peptides? The Honest Answer

Should You Be Using Peptides? The Honest Answer

Visit Peptide-Solutions.info for more info Check out App.PeptidesExplained.info Should you be using peptides? The honest answer is that not everyone should. Peptides are not a nutritional requirement,...

20 Aug 18min

ARA-290: Can It Repair Small Nerve Fibers?

ARA-290: Can It Repair Small Nerve Fibers?

ARA-290, also called cibinetide, is an investigational 11-amino-acid peptide designed from erythropoietin biology to activate tissue-protective signaling without stimulating red-blood-cell production....

18 Aug 17min

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