BRIDGING the Lipid Management Gap After ACS: ESC Late-Breaker | JACC Baran

BRIDGING the Lipid Management Gap After ACS: ESC Late-Breaker | JACC Baran

Hosts Mitsuaki Sawano, MD, and Shun Kohsaka, MD, welcome Kazuma Ohyama, MD, PhD (Tohoku University) to discuss the BRIDGE trial, Protocol-Based Implementation of Early Intensive Lipid Management After Acute Coronary Syndrome. In this 10-center cluster-randomized trial, hospitals were assigned to either protocol-based or standard lipid management after emergency PCI for ACS. Rather than simply reminding clinicians to intensify therapy, the intervention specified what treatment to initiate, when to reassess LDL-C, when to escalate therapy, and who was responsible for each step. At 6 months, LDL-C <70 mg/dL was achieved in 86.4% of patients in the protocol-based group versus 73.7% with standard care, while LDL-C <55 mg/dL was achieved in 60.8% versus 34.5%. The episode explores why implementation gaps persist despite strong evidence for statins, ezetimibe, and PCSK9 inhibitors, how cluster randomization helps evaluate system-level interventions, the practical role of CRC support and standardized care pathways, and how Japan-specific statin dosing should be considered when interpreting the results. Dr. Ohyama also shares the intense SimPub process surrounding ESC 2026, including multiple major revisions within days, and why the key message of BRIDGE is not simply that stronger drugs lower LDL-C, but that a simple, clearly assigned protocol can help translate established evidence into actual clinical practice.

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Episoder(93)

ICI Myocarditis: Does Timing Define the Disease? | JACC Baran

ICI Myocarditis: Does Timing Define the Disease? | JACC Baran

Is immune checkpoint inhibitor (ICI)-associated myocarditis the same disease when it occurs early versus months after starting cancer therapy? Host Mitsuaki Sawano, MD, and co-host Shun Kohsaka, MD, w...

3 Nov 34min

ICI Myocarditis: Does Timing Define the Disease? | JACC Baran

ICI Myocarditis: Does Timing Define the Disease? | JACC Baran

Is immune checkpoint inhibitor (ICI)-associated myocarditis the same disease when it occurs early versus months after starting cancer therapy? Host Mitsuaki Sawano, MD, and co-host Shun Kohsaka, MD, w...

3 Nov 34min

Does PFA Reach the Vein of Marshall? | JACC Baran

Does PFA Reach the Vein of Marshall? | JACC Baran

Does pulsed field ablation (PFA) for pulmonary vein isolation affect structures beyond the pulmonary veins? Host Mitsuaki Sawano, MD, welcomes Yosuke Nakatani, MD (Gunma University) to discuss his rec...

27 Okt 36min

A SELUTION to Paclitaxel DCB Complications in PAD? | JACC Baran

A SELUTION to Paclitaxel DCB Complications in PAD? | JACC Baran

Could sirolimus-coated balloons change how we treat femoropopliteal peripheral artery disease? Host Mitsuaki Sawano, MD, welcomes Yoshimitsu Soga, MD, PhD (Kokura Memorial Hospital) to discuss the 3-y...

20 Okt 28min

Proteomics in Action: Finding the Right Drug Targets for Ischemic Heart Disease | JACC Baran

Proteomics in Action: Finding the Right Drug Targets for Ischemic Heart Disease | JACC Baran

Which of the thousands of biomarkers associated with cardiovascular disease could actually become a useful drug target? Host Mitsuaki Sawano, MD, and co-host Nobuhiro Ikemura, MD, welcome Satoshi Yosh...

13 Okt 35min

PET Unmasks CMD: The Hidden Risk Behind Normal Perfusion | JACC Baran

PET Unmasks CMD: The Hidden Risk Behind Normal Perfusion | JACC Baran

Hosts Mitsuaki Sawano, MD, Satoshi Shoji, MD, and Kentaro Ejiri, MD, welcome Yoshito Kadoya, MD, PhD (University of British Columbia / St. Paul’s Hospital) to discuss his JACC: Cardiovascular Imaging ...

6 Okt 36min

Rethinking Health Care at Home and Abroad: Lancet RH Western Pacific Special | JACC Baran

Rethinking Health Care at Home and Abroad: Lancet RH Western Pacific Special | JACC Baran

Host Mitsuaki Sawano, MD, welcomes Shuhei Nomura, PhD (Tohoku University), Lisa Yamasaki, MD (Harvard T.H. Chan School of Public Health), and Haruka Sakamoto, MD, PhD (St. Luke’s International Hospita...

29 Sep 39min

PFA Changes the Game and the AT Circuit | JACC Baran

PFA Changes the Game and the AT Circuit | JACC Baran

Hosts Mitsuaki Sawano, MD, and Hiroyuki Sato, MD, welcome Kazutaka Nakasone, MD (Kobe University) to discuss his JACC: Clinical Electrophysiology study on atrial tachycardia (AT) after pulsed field ab...

22 Sep 36min

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