Communicable E63: Does oseltamivir harm critically ill patients? The REMAP-CAP results

Communicable E63: Does oseltamivir harm critically ill patients? The REMAP-CAP results

At the Critical Care Reviews meeting in Belfast in June this year, REMAP-CAP investigators presented results suggesting that oseltamivir may be harmful in critically ill patients with influenza, upending a long-standing clinical practice in intensive care [1]. In this fourth collaboration between SIDP’s Breakpoints and ESCMID’s Communicable podcasts, hosts Erin McCreary and Josh Davis are joined by Steve Webb (Monash University), senior REMAP-CAP investigator and 'godfather of adaptive trial design', and Steve Tong (University of Melbourne), esteemed clinical trialist and friend of both podcasts. Together, they walk through the trial domain’s design, outcomes and results, also highlighting how these findings demonstrate the importance and clinical impact of randomised clinical trials.

At the time of this episode recording in August, the results discussed were available as a preprint version [1].

Resources

  • REMAP-CAP: A Randomised, Embedded, Multi-factorial, Adaptive Platform Trial for Community-Acquired Pneumonia, https://www.remapcap.org/

References

  1. Murthy S, et al. Oseltamivir for Critically Ill Patients with Influenza: A Randomised Trial. Lancet 2026. Preprint http://dx.doi.org/10.2139/ssrn.7172531

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Episoder(65)

Communicable E64: Getting micro on macrolides for community-acquired pneumonia

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Communicable E62: The 'prose' and cons of the POET trial – early oral antibiotic switch for endocarditis

Communicable E62: The 'prose' and cons of the POET trial – early oral antibiotic switch for endocarditis

In this episode of Communicable, Emily McDonald and Josh Davis host Henning Bundgaard and Sami El-Dalati for a discussion on early oral antibiotic switch for endocarditis, focusing on the POET trial, ...

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Communicable E61: We will make you love PK/PD, part 3

Communicable E61: We will make you love PK/PD, part 3

In this episode of Communicable, Amy Legg (Brisbane, Australia), Rekha Pai Mangalore (Melbourne, Australia) & Angela Huttner (Geneva, Switzerland) return for the third part of the ‘We will make you lo...

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Communicable E60: Quarterly catch-up (August 2026 edition)

Communicable E60: Quarterly catch-up (August 2026 edition)

In the second edition of 'Quarterly catch-up', CMI Communications editors Emily McDonald and Erin McCreary round-up the biggest news in infectious diseases and review clinical microbiology and infecti...

9 Aug 49min

Communicable E59: 'Ask me anything' – EUCAST and CLSI leadership explain

Communicable E59: 'Ask me anything' – EUCAST and CLSI leadership explain

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26 Jul 1h 9min

Communicable E58: Reducing hospital-acquired pneumonia – the HAPPEN trial and how it happened

Communicable E58: Reducing hospital-acquired pneumonia – the HAPPEN trial and how it happened

In this episode of Communicable, Angela Huttner and Josh Davis are joined by Brett Mitchell, Aline Wolfensberger and Lauren Clack to discuss the HAPPEN trial to prevent hospital-acquired pneumonia led...

12 Jul 54min

Communicable E57: We will make you love PK/PD, part 2

Communicable E57: We will make you love PK/PD, part 2

In this episode of Communicable, Thomas Tängdén and Rekha Pai Mangalore return for part 2 of the ‘We will make you love PK/PD’ series. In this round, they are joined by Iris Minichmayr (Austria) and P...

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