They TRIPLED Wegovy Dose, Does it Beat Zepbound?

They TRIPLED Wegovy Dose, Does it Beat Zepbound?

This week on On The Pen, The Weekly Dose, we break down one of the biggest weeks in obesity medicine coming out of EASD 2026.Eli Lilly says Zepbound may still outperform Wegovy 7.2 mg, even after Novo Nordisk tripled the familiar maintenance dose, but the details are more complicated than the headline. We dig into the difference between the treatment-regimen and efficacy estimands, and why this was not a true head-to-head trial.We also cover Novo Nordisk’s $2.6 billion bet on a potential once-weekly oral GLP-1/GIP, new Foundayo data against high-dose oral semaglutide, Viatris and Mylan’s renewed patent fight over the future of generic Wegovy, and the full Phase 3 retatrutide publication in the New England Journal of Medicine.Plus, after weeks of concern over GLP-1 medications and NAION-related vision loss, we look at one practical thing patients may be able to do right now to better understand their own baseline risk.This episode is about more than who “wins” between Lilly and Novo. It is about what the data actually says, where the next generation of obesity treatment is headed, and what all of this means for patients trying to make informed decisions with their doctors.Covered in this episode: Zepbound vs. Wegovy 7.2 mg, retatrutide TRIUMPH-1 Phase 3 data, Foundayo/orforglipron, oral semaglutide, once-weekly oral GLP-1s, generic Wegovy patent litigation, NAION, GLP-1 vision risk, EASD 2026, Eli Lilly, Novo Nordisk, Viatris and Mylan.Subscribe for breaking GLP-1, obesity, diabetes and metabolic-health news, explained from the patient perspective.Get Exclusive OTP Savings and Resrouces:Https://www.otplinks.comGet Breaking Obesity Medicine News:HTTPS://www.onthepen.com

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Episoder(217)

NEW FDA ZEPBOUND WARNING!

NEW FDA ZEPBOUND WARNING!

VOTE FOR DAVE: https://tophost.org/2026/david-knappThe FDA just issued a NEW eye warning for EVERY GLP-1 medication, including Ozempic, Wegovy, Mounjaro, and Zepbound. But how worried should patients ...

10 Nov 28min

Novo's Next Weight Loss Pill Isn't a GLP-1, And That's HUGE

Novo's Next Weight Loss Pill Isn't a GLP-1, And That's HUGE

What if the next big breakthrough in obesity medicine isn't a GLP-1 at all?Novo Nordisk is developing an experimental oral weight-loss medication called LX9851, an ACSL5 inhibitor that targets an enti...

4 Nov 23min

Retatrutide Phase 3 Results: What You Need to Know

Retatrutide Phase 3 Results: What You Need to Know

Retatrutide’s New Phase 3 Data, CagriSema in Menopause, and the Growing GLP‑1 Access CrisisHost Dave Knapp recaps major obesity-drug updates, focusing on Eli Lilly’s triple agonist retatrutide and Nov...

27 Okt 31min

GLP-1 Recall Update: Why You Need to Check Your Vials

GLP-1 Recall Update: Why You Need to Check Your Vials

Specific lots of compounded tirzepatide have been recalled over sterility concerns, another pharmacy recently recalled compounded semaglutide after particulate matter was identified, patients have rep...

20 Okt 27min

Eli Lilly vs. The Grey Market: The Future of Peptide Medicine

Eli Lilly vs. The Grey Market: The Future of Peptide Medicine

Eli Lilly’s fight over retatrutide may be about much more than one obesity drug.I’ve been covering retatrutide since early 2023, and since late 2024 I’ve been closely following the legal fight over wh...

14 Okt 25min

Ozempic & Zepbound Are Changing America in Ways Nobody Expected

Ozempic & Zepbound Are Changing America in Ways Nobody Expected

Zepbound isn’t just changing people’s weight. GLP-1 medications are beginning to change America itself.Restaurants are rethinking what they serve. Grocery baskets are changing. Food companies are payi...

7 Okt 24min

Retatrutide in Court, Compound GLP-1 Under Fire

Retatrutide in Court, Compound GLP-1 Under Fire

This week on On The Pen, The Weekly Dose Podcast, retatrutide heads into a major federal court fight as the Department of Justice gives FDA fresh legal ammunition just days before oral argument.At the...

22 Sep 29min

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