Ep 129 Lymphatic Filariasis: Hiding in plain sight

Ep 129 Lymphatic Filariasis: Hiding in plain sight

With a history extending back millennia, with a biology that leads to permanent disability for tens of millions of people globally, and with a bacterial endosymbiont that may prove to be its Achilles heel, the filarial parasites that cause lymphatic filariasis are quite the complex creatures. In this episode, we explore the intricacies of this neglected tropical disease - also known as elephantiasis. We start by examining its complicated ecology involving many mosquito and parasite species, before moving on to its tricky biology where we finally answer the age-old question, “What is the lymphatic system anyway?”. Next, we move on to the convoluted history of lymphatic filariasis, where it holds the distinction of being the first disease recognized as mosquito-borne. We wrap up the episode with a look at its present global status, grappling with some current figures on the tremendous global burden of this disease and investigating some exciting treatment developments that will hopefully bring relief to the hundreds of millions of people at risk of developing this debilitating disease.

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Episoder(292)

Ep 214 Boogers: Digging for treasure

Ep 214 Boogers: Digging for treasure

Hard and crusty. Green and gloopy. Clear and watery. Boogers come in a veritable rainbow of colors and a full spectrum of textures from liquid to solid. They’re really quite impressive if you think ab...

30 Jun 1h 2min

Special Episode: Dr. Carl Elliott & The Occasional Human Sacrifice

Special Episode: Dr. Carl Elliott & The Occasional Human Sacrifice

Stories of unethical medical experimentation often center around the individuals who spearheaded such atrocities or highlight how patient protection laws were changed in response to the studies. But r...

23 Jun 57min

Ep 213 Burns Part 2: It’s like sci-fi but real 

Ep 213 Burns Part 2: It’s like sci-fi but real 

At the turn of the 20th century, a severe burn was often a death sentence. Today, that is no longer the case. Over the past eighty years, burn care has undergone a profound transformation thanks to cr...

16 Jun 58min

Ep 212 Burns Part 1: The first million or so years

Ep 212 Burns Part 1: The first million or so years

Burns have been a part of the human experience since our hominin relatives began controlling fire 1.5 million years ago. Until very recently, we’ve been limited in our ability to manage burn wounds wi...

9 Jun 55min

Special Episode: Alexandra Sifferlin & The Elusive Body

Special Episode: Alexandra Sifferlin & The Elusive Body

An accurate diagnosis can give us so much. It can give us a path forward. It can give us answers to long-standing questions. And it can give us much-needed hope. Yet many people around the world wait ...

2 Jun 51min

Ep 211 Motion Sickness: It comes in waves

Ep 211 Motion Sickness: It comes in waves

It comes on sneakily. You become aware of your stomach. You break out in a cold sweat. Your mouth fills with saliva. And before you know it, you’re leaning over the side of the boat (or out of the car...

26 Mai 1h 16min

Ep 210 Histoplasmosis: Bats, birds, and budding yeast

Ep 210 Histoplasmosis: Bats, birds, and budding yeast

Once thought to be a rare, always fatal disease, histoplasmosis is now recognized as one of the most prevalent fungal infections in North America. It infects hundreds of thousands of people every year...

19 Mai 1h 18min

Special Episode: Dr. Olivia Weisser & The Dreaded Pox

Special Episode: Dr. Olivia Weisser & The Dreaded Pox

In a time when smallpox, tuberculosis, measles, and typhus ran rampant through the streets of London, there was another disease that instilled even more fear than these other killers: syphilis. So fea...

12 Mai 51min

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