Pro Pharma Talks10 Sep 2020

Let's Talk About Colon Cancer

What is it?

Colorectal cancer
3rd most diagnosed cancer in US (men & women)
S/S = blood in stool, GI irritation, irregular stools, chronic diarrhea, sudden weight loss
Diagnostic = colonoscopy – polyps, inflammation, ulcers, abnormal growths
ACS testing guidelines
- Asymptomatic, negative family history, no polyps – every 10 years
- Low-risk polyps – 5 years
- High-risk polyps

What causes it?

Cause
- Age (90% of cases for people > 50 y/o)
- Family history
- Race – African Americans (new Dx 20% higher in Blacks, and death rates 40% higher)
- Ethnicity – Ashkenazi Jews
- Ulcerative colitis, Crohn’s disease
- Low whole grain diets
- Genetic predisposition
- Smoking, alcohol use, lack of exercise, diabetes

How is it treated?

Stage O, I -- Sx
Stage II – Sx + Adj Chemo
Stage III – Sx + Adj Chemo
Stage IV – Sx + Chemo
- Chemo + Targeted Tx
- Gene types – + immunotherapy
- Radiation

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