Can CD47 antibody therapy be safely used for AML and MDS?
AML Hub22 Jun 2020

Can CD47 antibody therapy be safely used for AML and MDS?

During the 25th Congress of the European Hematology Association (EHA), the AML Hub hosted a discussion between David Sallman, Moffitt Cancer Center, Tampa, US, and Steering Committee Member Naval Daver, MD Anderson Cancer Center, Houston, US.


The question was, Is CD47-directed antibody therapy safe and effective in patients with AML and myelodysplastic syndromes?


CD47 is a dominant negative immune checkpoint expressed by cancer cells, which facilitates immune evasion by decreasing recognition by macrophages. Increased expression of CD47 on cancer cells has been associated with inferior survival in patients with AML. The first-in-class anti-CD47 antibody magrolimab reinstates macrophage-mediated phagocytosis of tumor cells and has demonstrated anti-tumor activity in preclinical models.


Here, David Sallman and Naval Daver discuss the potential and clinical status of CD47-directed antibody therapy for the treatment of AML and myelodysplastic syndromes.

Hosted on Acast. See acast.com/privacy for more information.

Episoder(35)

What is the impact of the 5th WHO classification and ICC of AML on diagnosis and treatment of high-risk AML​?

What is the impact of the 5th WHO classification and ICC of AML on diagnosis and treatment of high-risk AML​?

The AML Hub was pleased to speak with Gail Roboz, Weill Cornell Medicine, New York, US. We asked, What is the impact of the 5th World Health Organization (WHO) classification and International Consens...

17 Sep 202413min

What were your highlights from ASH 2023?

What were your highlights from ASH 2023?

During the 65th American Society of Hematology (ASH) Annual Meeting and Exposition, Michal Bar-Natan, Weill Cornell Medicine, New York, US, shared her highlights with the AML Hub. Hosted on Acast. Se...

29 Apr 20243min

What are the challenges associated with CAR T-cell therapy in patients with AML?

What are the challenges associated with CAR T-cell therapy in patients with AML?

During the 6th European CAR T-Cell Meeting, the AML Hub spoke to Sarah Tettamanti, Tettamanti Foundation Research Center, Monza, IT. We asked, What are the challenges associated with CAR T-cell therap...

25 Apr 20249min

How might the MORPHO trial of gilteritinib impact clinical practice?

How might the MORPHO trial of gilteritinib impact clinical practice?

The AML Hub spoke to Charles Craddock, Queen Elizabeth Hospital Birmingham, Birmingham, UK at ASH 2023. We asked, How might the MORPHO trial of gilteritinib impact clinical practice? Hosted on Acast. ...

8 Apr 20247min

Risk stratification and guidelines in AML management

Risk stratification and guidelines in AML management

The AML Hub was pleased to speak to Gail Roboz, Weill Cornell Medicine, New York, US, and Naval Daver, MD Anderson Cancer Center, Houston, US. We asked about risk stratification and guidelines in acut...

8 Jan 202411min

How are new fludarabine conditioning combinations impacting transplant outcomes?

How are new fludarabine conditioning combinations impacting transplant outcomes?

During the virtual 48th Annual Meeting of the European Society for Blood and Marrow Transplantation (EBMT), the AML Hub spoke with Eleni Gavriilaki, George Papanikolaou General Hospital of Thessalonik...

22 Apr 20226min

Should pre-transplant MRD be used to guide treatment in AML?

Should pre-transplant MRD be used to guide treatment in AML?

During the EHA2021 Virtual Congress, the AML Hub spoke with Arnon Nagler, Tel Aviv University, Tel Aviv, IL. We asked, Should pre-transplant measurable residual disease (MRD) be used to guide treatmen...

10 Jul 20216min

Should pre-transplant MRD be used to guide treatment in AML?

Should pre-transplant MRD be used to guide treatment in AML?

During the EHA2021 Virtual Congress, the AML Hub spoke with Charles Craddock, Queen Elizabeth Hospital Birmingham, Birmingham, UK. We asked, Should pre-transplant minimal residual disease (MRD) be use...

25 Jun 202113min

Populært innen Fakta

fastlegen
dine-penger-pengeradet
relasjonspodden-med-dora-thorhallsdottir-kjersti-idem
treningspodden
rss-strid-de-norske-borgerkrigene
foreldreradet
jakt-og-fiskepodden
rss-sunn-okonomi
merry-quizmas
hverdagspsyken
gravid-uke-for-uke
sinnsyn
rss-mann-i-krise-med-sagen
rss-impressions-2
rss-kunsten-a-leve
hagespiren-podcast
babyverden
level-up-med-anniken-binz
fryktlos
nevropodden