Approaches and emerging therapies for TP53 AML
AML Hub1 Jul 2020

Approaches and emerging therapies for TP53 AML

During the 25th Congress of the European Hematology Association (EHA), the AML Hub spoke to a member of our steering committee, Naval Daver, The University of Texas MD Anderson Cancer Center, Houston, US, about novel approaches and emerging therapies for TP53 AML.


Identification of disease-driving genetic aberrations has allowed for major advancements in the AML setting. TP53 mutations are observed in around 15% of patients with AML, with distinct patterns between patient subsets. Despite the development of targeted therapies, such as FLT3 and IDH1/2 inhibitors, treatments targeting TP53 mutations are yet to be established.


TP53-mutant AML is an area of unmet need, demonstrating high interpatient heterogeneity. Here, Naval Daver describes the efforts being made to establish TP53 as a therapeutic target, with the aim to further improve patient outcomes.

Hosted on Acast. See acast.com/privacy for more information.

Episoder(35)

Symposium | Understanding the differences between FLT3-ITD and -TKD mutations in AML: Q&A

Symposium | Understanding the differences between FLT3-ITD and -TKD mutations in AML: Q&A

The AML Hub held a virtual symposium on November 19, 2025, titled Understanding the differences between FLT3-ITD and -TKD mutations in AML: Implications for clinical practice. The symposium ended with...

12 Feb 7min

Symposium | Implications for clinical practice: Managing AML with FLT3-ITD and -TKD mutations

Symposium | Implications for clinical practice: Managing AML with FLT3-ITD and -TKD mutations

The AML Hub held a virtual symposium on November 19, 2025, titled Understanding the differences between FLT3-ITD and -TKD mutations in AML: Implications for clinical practice. Here, we share a present...

11 Feb 14min

Symposium | Comparing treatment options for patients with FLT3-ITD and -TKD mutations

Symposium | Comparing treatment options for patients with FLT3-ITD and -TKD mutations

The AML Hub held a webinar on November 19, 2025, titled, Understanding the differences between FLT3-ITD and -TKD mutations in AML: Implications for clinical practice. Here, we share a presentation fro...

19 Jan 20min

Symposium | FLT3 mutations in AML: Types, prevalence, and clinical significance

Symposium | FLT3 mutations in AML: Types, prevalence, and clinical significance

The AML Hub held a webinar on November 19, 2025, titled, “Understanding the differences between FLT3-ITD and -TKD mutations in AML: Implications for clinical practice.” Here, we share one of the prese...

14 Jan 16min

ASH 2025 | Pivekimab sunirine + Ven + Aza in unfit patients with ND CD123+ AML: Phase Ib/II efficacy and safety

ASH 2025 | Pivekimab sunirine + Ven + Aza in unfit patients with ND CD123+ AML: Phase Ib/II efficacy and safety

Following the 67th American Society of Hematology (ASH) Annual Meeting and Exposition, December 6–9, 2025, Orlando, US, the AML Hub was pleased to speak with Gail Roboz, Weill Cornell Medicine, New Yo...

13 Jan 8min

ASH 2025 | PARADIGM: Azacitidine + venetoclax vs conventional induction in fit adults with ND AML

ASH 2025 | PARADIGM: Azacitidine + venetoclax vs conventional induction in fit adults with ND AML

Following the 67th American Society of Hematology (ASH) Annual Meeting and Exposition, December 6–9, 2025, Orlando, US, the AML Hub was pleased to speak with Amir Fathi, Massachusetts General Hospital...

18 Des 20257min

Clinical research round-up: Current and emerging treatments for IDH1-mutated AML

Clinical research round-up: Current and emerging treatments for IDH1-mutated AML

The AML Hub was pleased to speak with Eytan Stein, Memorial Sloan Kettering Cancer Center, New York, US. We asked, What are the latest data presented on current and emerging treatments for acute myelo...

6 Nov 20254min

Menin inhibitors in AML: Bridging the gap between trial data and clinical practice

Menin inhibitors in AML: Bridging the gap between trial data and clinical practice

The AML Hub was pleased to speak with Emma Searle, The Christie NHS Foundation Trust, Manchester, UK. We asked for her thoughts on the topic “Menin inhibitors in AML: Bridging the gap between trial da...

24 Okt 20257min

Populært innen Fakta

fastlegen
dine-penger-pengeradet
relasjonspodden-med-dora-thorhallsdottir-kjersti-idem
foreldreradet
treningspodden
rss-strid-de-norske-borgerkrigene
jakt-og-fiskepodden
sinnsyn
rss-sunn-okonomi
mikkels-paskenotter
hverdagspsyken
gravid-uke-for-uke
rss-kunsten-a-leve
takk-og-lov-med-anine-kierulf
rss-kull
hagespiren-podcast
rss-var-forste-kaffe
fryktlos
rss-mann-i-krise-med-sagen
tomprat-med-gunnar-tjomlid