Will Taking GH Before Going To Sleep Suppress Your Natural Production Of GH?

Will Taking GH Before Going To Sleep Suppress Your Natural Production Of GH?

At supraphysiological dosages, taking GH before going to sleep makes sense because there is a negative feedback loop on the growth hormone (GH)/insulin-like growth factor I (IGF-1) axis. In this study, IGF-1 was constantly infused, and the effect on endogenous GH secretion was assessed [R]. Overall, GH concentrations were suppressed during the rhIGF-I infusion by 85±3%, mainly by attenuating spontaneous GH pulse amplitude (77±4% suppression). The apparent GH pulse frequency was attenuated from 7.8±0.9 to 4.7±0.6 pulses/24h (P= 0.006). IGF-1 is the primary feedback, and the mechanism is similar to what you see with the HPTA axis. When there is enough Testosterone and Estrogen, your body has this mechanism in place to prevent you from making more. The same thing happens with exogenous GH use. When you administer exogenous GH, IGF-1 elevates. When your body recognizes that IGF-1 is elevated, it starts to suppress GH pulse amplitude in a dose dependent manner. If you are using supraphysiological amounts of GH for bodybuilding purposes, you can assume that your natural secretion is greatly inhibited during sleep as this negative feedback loop will prevent your body from secreting GH in your sleep like it normally would. When endogenous GH production is suppressed, administering exogenous GH at times that lipolysis or muscle growth can be optimized is the most logical approach to injection timing. https://youtu.be/8j9MGfQPeXg If fat loss is the goal, then taking GH in a fasted state prior to fasted cardio would be ideal. There is a ceiling on how much GH is needed to maximize lipolysis, so if your dosage exceeds 2 IU per day, then I would advise splitting up that dose into two (or more if needed) different periods of the day with as much time between them as possible. If muscle growth is the goal, GH should still be administered in a pulsatile fashion to mimic endogenous secretions. Topped out stimulation of autocrine IGF-1 in skeletal muscle can be achieved with fairly low dosages of exogenous GH, and administering a higher dose above and beyond that may just be a waste. This is why it would be wise to split up your daily GH dose into multiple administrations if you are using supraphysiological dosages. Learn more about your ad choices. Visit megaphone.fm/adchoices

Episoder(1360)

David Sinclair Supplements For Anti-Aging – What He Takes & Why

David Sinclair Supplements For Anti-Aging – What He Takes & Why

David Sinclair is a professor of genetics at the forefront of anti-aging research. I've taken note of his work, and as someone extremely interested in maximizing my longevity and vitality, I have incorporated a couple of his daily supplements into my own routine that I wasn't already using.… Learn more about your ad choices. Visit megaphone.fm/adchoices

27 Jun 201910min

Old Man Reverses Hair Loss Via A Scalp Burn In A Coal Fire!?

Old Man Reverses Hair Loss Via A Scalp Burn In A Coal Fire!?

This story is something I stumbled across by accident. It's really interesting as it backs up the theory of wounding, and also implies the importance of Prostaglandins and the recruitment of growth factors via a stimulus. In this story, a 78-year-old man with common male pattern baldness was dozing off in his armchair when he fell head first into a coal fire.… Learn more about your ad choices. Visit megaphone.fm/adchoices

26 Jun 20194min

The TOP 3 Places To Meet Women | Even If You Have No Friends

The TOP 3 Places To Meet Women | Even If You Have No Friends

This is also applicable if you moved to a new area and literally don't know anybody, which can feel very overwhelming. A quick disclaimer before we being, it should also go without saying that online dating is a no-brainer to supplement your cold approaching with, but this article is going to address cold approaching specifically.… Learn more about your ad choices. Visit megaphone.fm/adchoices

26 Jun 201911min

DNP Review | Fat Loss, Side Effects, and Conclusions Made Afterward

DNP Review | Fat Loss, Side Effects, and Conclusions Made Afterward

What Is DNP? 2,4-Dinitrophenol, also called DNP, is a chemical uncoupling agent that inhibits the production of ATP in cells with mitochondria. Via uncoupling oxidative phosphorylation, DNP raises body temperature in a dose dependent manner. DNP use is the most frowned upon practice in the bodybuilding world aside from Synthol in my opinion.… Learn more about your ad choices. Visit megaphone.fm/adchoices

23 Jun 20195min

My First Steroid Cycle | What I Would Change If I Could Go Back In Time

My First Steroid Cycle | What I Would Change If I Could Go Back In Time

My First Steroid Cycle Most of you guys know I use a high-normal dose of TRT. I try to keep myself right on the cusp of supraphysiological Testosterone levels. In the past I've blasted with supraphysiological amounts numerous times, and the first steroid cycle in particular is what I want to delve into today.… Learn more about your ad choices. Visit megaphone.fm/adchoices

21 Jun 20193min

How To Get Blood Work In Canada | High Quality Testing Over The Border

How To Get Blood Work In Canada | High Quality Testing Over The Border

How To Get Blood Work In Canada I always get asked how to get blood work in Canada. In Canada it's not so simple, as you have to go to your doctor and they have to prescribe you the tests you want.… Learn more about your ad choices. Visit megaphone.fm/adchoices

20 Jun 20194min

What Causes “Alien Gains”? | Unsurprisingly, It’s Not Muscle Control

What Causes “Alien Gains”? | Unsurprisingly, It’s Not Muscle Control

What Causes Alien Gains I've seen quite a few videos now on YouTube and Instagram with guys showing off their rippling, spasming muscles, and the slang term has dubbed them as “Alien Gains”. View this post on Instagram How all this started -> that’s it bro. … Learn more about your ad choices. Visit megaphone.fm/adchoices

20 Jun 20194min

How To Increase Low HDL Cholesterol Levels With Niacin, Krill Oil & Cardarine

How To Increase Low HDL Cholesterol Levels With Niacin, Krill Oil & Cardarine

Chronically Low HDL Cholesterol Levels From TRT It's very common for men on TRT to have really low HDL cholesterol levels. I have the same issue. Anyone on exogenous androgens, regardless if it's SARMs, steroids, or prohormones, will likely have a suboptimal lipid profile.… Learn more about your ad choices. Visit megaphone.fm/adchoices

17 Jun 20195min

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