Will Taking GH Before Going To Sleep Suppress Your Natural Production Of GH?

Will Taking GH Before Going To Sleep Suppress Your Natural Production Of GH?

At supraphysiological dosages, taking GH before going to sleep makes sense because there is a negative feedback loop on the growth hormone (GH)/insulin-like growth factor I (IGF-1) axis. In this study, IGF-1 was constantly infused, and the effect on endogenous GH secretion was assessed [R]. Overall, GH concentrations were suppressed during the rhIGF-I infusion by 85±3%, mainly by attenuating spontaneous GH pulse amplitude (77±4% suppression). The apparent GH pulse frequency was attenuated from 7.8±0.9 to 4.7±0.6 pulses/24h (P= 0.006). IGF-1 is the primary feedback, and the mechanism is similar to what you see with the HPTA axis. When there is enough Testosterone and Estrogen, your body has this mechanism in place to prevent you from making more. The same thing happens with exogenous GH use. When you administer exogenous GH, IGF-1 elevates. When your body recognizes that IGF-1 is elevated, it starts to suppress GH pulse amplitude in a dose dependent manner. If you are using supraphysiological amounts of GH for bodybuilding purposes, you can assume that your natural secretion is greatly inhibited during sleep as this negative feedback loop will prevent your body from secreting GH in your sleep like it normally would. When endogenous GH production is suppressed, administering exogenous GH at times that lipolysis or muscle growth can be optimized is the most logical approach to injection timing. https://youtu.be/8j9MGfQPeXg If fat loss is the goal, then taking GH in a fasted state prior to fasted cardio would be ideal. There is a ceiling on how much GH is needed to maximize lipolysis, so if your dosage exceeds 2 IU per day, then I would advise splitting up that dose into two (or more if needed) different periods of the day with as much time between them as possible. If muscle growth is the goal, GH should still be administered in a pulsatile fashion to mimic endogenous secretions. Topped out stimulation of autocrine IGF-1 in skeletal muscle can be achieved with fairly low dosages of exogenous GH, and administering a higher dose above and beyond that may just be a waste. This is why it would be wise to split up your daily GH dose into multiple administrations if you are using supraphysiological dosages. Learn more about your ad choices. Visit megaphone.fm/adchoices

Episoder(1360)

Dorian Yates Genetics And Training Style – Which Was More Important?

Dorian Yates Genetics And Training Style – Which Was More Important?

Dorian Yates Work Ethic Dorian Yates is highly regarded for his extreme work ethic. He is often referred to as an example of hard work beating talent–or genetics. Many truly believe that he was just such a hard worker in the gym that it allowed him to overcome genetic deficiencies and grind his way to six consecutive Mr.… Learn more about your ad choices. Visit megaphone.fm/adchoices

13 Apr 20195min

Beta Males – The Reason Why There’s Less Competition Than Ever In The Dating Pool

Beta Males – The Reason Why There’s Less Competition Than Ever In The Dating Pool

Why There Are A Increasing Number Of Beta Males I'm sure you've noticed as the years progress that beta males and “soy boys” are increasing in exponential proportions. Men in general are becoming more and more feminine. A lot of people think it is associated with the decline in natural testosterone levels as time goes on.… Learn more about your ad choices. Visit megaphone.fm/adchoices

12 Apr 20197min

TJ Dillashaw Tests Positive For EPO – Analysis Of UFC PED Choices

TJ Dillashaw Tests Positive For EPO – Analysis Of UFC PED Choices

TJ Dillashaw Tests Positive For EPO (Former) UFC Champion TJ Dillashaw has been suspended for 2 years after testing positive for EPO. I'm not a huge UFC fan but I do tune in once in a while and this particular topic intrigued me.… Learn more about your ad choices. Visit megaphone.fm/adchoices

12 Apr 20198min

How Long Does It Take To Look Like You Lift? | How Many Years Did It Take Me?

How Long Does It Take To Look Like You Lift? | How Many Years Did It Take Me?

Individual Perspective Will Determine If You Look Like You Lift The definition of looking fit varies individual to individual. Each one of us has a subjective feeling towards different body shapes and builds. For many girls, their perception of muscular development is so vastly different from guys in the bodybuilding community, that they'll perceive someone like Taylor Lautner from Twilight the same way we'd perceive a Mr Olympia champion like Phil Heath.… Learn more about your ad choices. Visit megaphone.fm/adchoices

11 Apr 20191min

Insulin & Body Fat Gain – The Number 1 Reason Why 90% Of Bodybuilders Just Get Fat

Insulin & Body Fat Gain – The Number 1 Reason Why 90% Of Bodybuilders Just Get Fat

Does Insulin Make You Fat? No. A diet with too many calories makes you fat. The problem with insulin use in bodybuilding is that the protocols given out typically don’t make any logical sense. The problem boils down to bodybuilders eating excessive amounts to match their arbitrary insulin dosages, as opposed to how a diabetic would use inuslin (the correct way) where the insulin dosage matches the diet.… Learn more about your ad choices. Visit megaphone.fm/adchoices

29 Mar 20196min

Accutane Review – How I Got Rid Of My Acne Permanently

Accutane Review – How I Got Rid Of My Acne Permanently

What Is Accutane? Accutane is a brand name for the drug Isotretinoin. This drug became extremely popular (and remains to this day) for its overall efficacy in getting rid of acne, and preventing it from coming back. When I was a teenager I had really bad acne.… Learn more about your ad choices. Visit megaphone.fm/adchoices

28 Mar 20194min

How To Increase Your Penis Size Without Pumps, Stretchers, Or Manual Exercises

How To Increase Your Penis Size Without Pumps, Stretchers, Or Manual Exercises

Losing Fat To Increase Your Penis Size The only way to increase your penis size without pumps, stretchers, or manual exercises is by getting shredded. When you want add new permanent size, a consistent jelqing and stretching regimen in conjunction with the Bathmate pump and a good extender to prevent turtling are the gold standard and will net you 2-3 inches in length and girth if you are religious about your routine.… Learn more about your ad choices. Visit megaphone.fm/adchoices

27 Mar 20193min

How Many Milligrams Of Testosterone Do Men Naturally Produce? | Comparison To TRT Dosages

How Many Milligrams Of Testosterone Do Men Naturally Produce? | Comparison To TRT Dosages

How many milligrams of Testosterone do men naturally produce? 3-10 milligrams per day, with the average being 6-7 milligrams per day. What Is A Therapeutic Dosage Of Testosterone? When bodybuilders refer to Testosterone Replacement Therapy (TRT) dosages they’ll often state that 200 milligrams is a therapeutic dosage.… Learn more about your ad choices. Visit megaphone.fm/adchoices

26 Mar 20197min

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