Will Taking GH Before Going To Sleep Suppress Your Natural Production Of GH?

Will Taking GH Before Going To Sleep Suppress Your Natural Production Of GH?

At supraphysiological dosages, taking GH before going to sleep makes sense because there is a negative feedback loop on the growth hormone (GH)/insulin-like growth factor I (IGF-1) axis. In this study, IGF-1 was constantly infused, and the effect on endogenous GH secretion was assessed [R]. Overall, GH concentrations were suppressed during the rhIGF-I infusion by 85±3%, mainly by attenuating spontaneous GH pulse amplitude (77±4% suppression). The apparent GH pulse frequency was attenuated from 7.8±0.9 to 4.7±0.6 pulses/24h (P= 0.006). IGF-1 is the primary feedback, and the mechanism is similar to what you see with the HPTA axis. When there is enough Testosterone and Estrogen, your body has this mechanism in place to prevent you from making more. The same thing happens with exogenous GH use. When you administer exogenous GH, IGF-1 elevates. When your body recognizes that IGF-1 is elevated, it starts to suppress GH pulse amplitude in a dose dependent manner. If you are using supraphysiological amounts of GH for bodybuilding purposes, you can assume that your natural secretion is greatly inhibited during sleep as this negative feedback loop will prevent your body from secreting GH in your sleep like it normally would. When endogenous GH production is suppressed, administering exogenous GH at times that lipolysis or muscle growth can be optimized is the most logical approach to injection timing. https://youtu.be/8j9MGfQPeXg If fat loss is the goal, then taking GH in a fasted state prior to fasted cardio would be ideal. There is a ceiling on how much GH is needed to maximize lipolysis, so if your dosage exceeds 2 IU per day, then I would advise splitting up that dose into two (or more if needed) different periods of the day with as much time between them as possible. If muscle growth is the goal, GH should still be administered in a pulsatile fashion to mimic endogenous secretions. Topped out stimulation of autocrine IGF-1 in skeletal muscle can be achieved with fairly low dosages of exogenous GH, and administering a higher dose above and beyond that may just be a waste. This is why it would be wise to split up your daily GH dose into multiple administrations if you are using supraphysiological dosages. Learn more about your ad choices. Visit megaphone.fm/adchoices

Episoder(1360)

Why You Shouldn’t Take Advice From Bodybuilders With Great Genetics

Why You Shouldn’t Take Advice From Bodybuilders With Great Genetics

There are an increasing amount of bodybuilders with great genetics who are now coaches. They are often referred to as gurus, and some were even legendary bodybuilders themselves. A handful were even Mr. Olympia contenders, or champions themselves. But should we take bodybuilding advice from them?… Learn more about your ad choices. Visit megaphone.fm/adchoices

11 Mai 20199min

Is A High Protein Diet Dangerous? – Study Shows That 1.5 Grams Of Protein Per Pound Of Body Weight Is Safe

Is A High Protein Diet Dangerous? – Study Shows That 1.5 Grams Of Protein Per Pound Of Body Weight Is Safe

There have been a few videos I've done in the past on protein intake and diet hacks that will make it a lot easier to hit your daily requirements. There's always the guys who pop in on there who try to argue that you don't need that much protein to recover properly, or that a high protein diet is dangerous.… Learn more about your ad choices. Visit megaphone.fm/adchoices

10 Mai 20194min

How To Maintain Cardiovascular Health While Bodybuilding | Which Tests To Get And Health Supplements I Use

How To Maintain Cardiovascular Health While Bodybuilding | Which Tests To Get And Health Supplements I Use

For most of us, preventing heart disease depends largely on our lifestyle, which means there's much that's in our power to maintain cardiovascular health while bodybuilding. Despite fit looking physiques being portrayed as examples of optimized health, the reality is that bodybuilding is one of the most unhealthy things you can do from a cardiac perspective.… Learn more about your ad choices. Visit megaphone.fm/adchoices

10 Mai 201927min

Does Muscle Size Determine Strength? | Is A Bigger Muscle A Stronger Muscle?

Does Muscle Size Determine Strength? | Is A Bigger Muscle A Stronger Muscle?

Muscle Strength Vs. Muscle Size There is a very common saying, and it is, “a bigger muscle is a stronger muscle.” And I don't know where that originated from. But it has been getting passed down through the grapevine over the years.… Learn more about your ad choices. Visit megaphone.fm/adchoices

9 Mai 20195min

Do Androgen Receptors Downregulate From Continuous Steroid Use?

Do Androgen Receptors Downregulate From Continuous Steroid Use?

Do Androgen Receptors Downregulate? There is a very common misconception in the bodybuilding community that androgen receptors downregulate during a steroid cycle, or during long-term steroid use. A plateau in muscle gain is commonly attributed to this “androgen receptor downregulation”. If you've ever cycled anabolics, you can also attest to the fact that during a new cycle the gains always seem to come within the first 8 weeks or so, and then the weeks following that it is typical to notice a blatant diminishing returns effect.… Learn more about your ad choices. Visit megaphone.fm/adchoices

27 Apr 20196min

Intermittent Fasting For Bodybuilding | Is It Good Or Bad For Gaining Muscle And Fat Loss?

Intermittent Fasting For Bodybuilding | Is It Good Or Bad For Gaining Muscle And Fat Loss?

The Best Diet For Adherence There is a lot of controversy around intermittent fasting for bodybuilding goals, and whether or not it is a suboptimal way to gain muscle or lose fat. There are a lot of mixed opinions, and I get asked a lot what I think about it as a diet style.… Learn more about your ad choices. Visit megaphone.fm/adchoices

25 Apr 20195min

How To Build Social Circles In College With Attractive Women Quickly | Even When You Don’t Know Anyone

How To Build Social Circles In College With Attractive Women Quickly | Even When You Don’t Know Anyone

The Moment I Learned That Rejections Aren't All Dead Ends This strategy can be used wherever you live, regardless of what school you are at. While some of you guys might be in fraternities, or have thriving social scenes at the schools you go to, there are a lot of colleges and universities that have no parties, no night life, and are essentially just commuter schools.… Learn more about your ad choices. Visit megaphone.fm/adchoices

20 Apr 201912min

How To Get Shredded Eating McDonalds Every Day | IIFYM (If It Fits Your Macros)

How To Get Shredded Eating McDonalds Every Day | IIFYM (If It Fits Your Macros)

Getting Shredded On Junk Food Obviously, trying to get shredded eating McDonalds every day is not the optimal way to diet. This post is not meant to assert that you should diet down eating McDonalds every day, it is simply meant to illustrate how the metabolism works, and how daily calorie intake relative to daily energy expenditure is ultimately what will determine if you lose fat or not.… Learn more about your ad choices. Visit megaphone.fm/adchoices

19 Apr 20197min

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