Spatial Organization of the Human Genome (Wendy Bickmore)

Spatial Organization of the Human Genome (Wendy Bickmore)

In recent years it has become more and more evident, that genome folding and chromatin packaging into the nucleus plays a pivotal role in the regulation of gene expression. In this Episode of our Podcast our host Dr. Stefan Dillinger spoke with Professor Wendy Bickmore about her work on the spatial organization of the human genome. Prof. Bickmore and her team mainly use visual methods like fluorescence in situ hybridisation (FISH) to study the organization of chromosomes in human and murine cells and how they contribute to transcriptional regulation and how this organization changes during ageing, development or disease.

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Episoder(170)

Gene Expression Control and Intricacies of X-chromosome Inactivation (Claire Rougeulle)

Gene Expression Control and Intricacies of X-chromosome Inactivation (Claire Rougeulle)

In this episode of the Epigenetics Podcast, we talked with Claire Rougeulle from the Epigenetics and Cell Fate Center at Université Paris City about her work on gene expression control, the intricacie...

25 Jul 202438min

Epigenetic Mechanisms in Genome Regulation and Developmental Programming (James Hackett)

Epigenetic Mechanisms in Genome Regulation and Developmental Programming (James Hackett)

In this episode of the Epigenetics Podcast, we talked with James Hackett from the EMBL in Rome about his work on epigenetic mechanisms in genome regulation and developmental programming. One of James ...

11 Jul 202437min

Advanced Optical Imaging in 3D Nuclear Organisation (Lothar Schermelleh)

Advanced Optical Imaging in 3D Nuclear Organisation (Lothar Schermelleh)

In this episode of the Epigenetics Podcast, we talked with Lothar Schermelleh from the University of Oxford about his work on advanced optical imaging in 3D nuclear organisation.  The interview start...

27 Jun 202446min

DNA Replication, Transcription and R-loops (Stephan Hamperl)

DNA Replication, Transcription and R-loops (Stephan Hamperl)

In this episode of the Epigenetics Podcast, we talked with Dr. Stephan Hamperl from the Helmholtz Zentrum Munich about his work on how conflicts between transcription, replication, and R-loop formatio...

13 Jun 202434min

Mutations of Gene Regulatory Elements in Human Disease (Nadav Ahituv)

Mutations of Gene Regulatory Elements in Human Disease (Nadav Ahituv)

In this episode of the Epigenetics Podcast, we talked with Nadav Ahituv from University of California, San Francisco about his work on mutations of gene regulatory elements in human disease. Using mas...

30 Mai 202449min

Using Single-Cell Multiomics to Characterize Human Developmental Hematopoiesis (Ana Cvejic)

Using Single-Cell Multiomics to Characterize Human Developmental Hematopoiesis (Ana Cvejic)

In this episode of the Epigenetics Podcast, we talked with Ana Cvejic from the Biotech Research & Innovation Centre at the University of Copenhagen about her work on using sc-multiomics to characteris...

16 Mai 202437min

The Impact of Sequence Variation on Transcription Factor Binding (Sven Heinz)

The Impact of Sequence Variation on Transcription Factor Binding (Sven Heinz)

In this episode of the Epigenetics Podcast, we talked with Sven Heinz from the University of California in San Diego about his work on the impact of sequence variation on transcription factor binding ...

2 Mai 202440min

Comparing CUT&Tag to ENCODE ChIP-Seq in Alzheimer's Disease Samples (Sarah Marzi)

Comparing CUT&Tag to ENCODE ChIP-Seq in Alzheimer's Disease Samples (Sarah Marzi)

In this episode of the Epigenetics Podcast, we talked with Sarah Marzi from the UK Dementia Research Institute at Imperial College London about her work on epigenetic changes in Alzheimer's Disease, a...

18 Apr 202446min

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