Influence of Histone Variants on Chromatin Structure and Metabolism (Markus Buschbeck)

Influence of Histone Variants on Chromatin Structure and Metabolism (Markus Buschbeck)

In this episode of the Epigenetics Podcast, we sat down with Marcus Buschbeck, Group Leader at the Josep Carreras Leukaemia Research Institute in Barcelona, to talk about his work on the histone variant macroH2A, its role in metabolism and how it contributes to the regulation of chromatin structure.

Histone variants equip chromatin with unique properties and show a specific genomic distribution. The histone variant macroH2A is unique in having a tripartite structure consisting of a N-terminal histone-fold, an intrinsically unstructured linker domain and a C-terminal macro domain. Recent discoveries show that macroH2A proteins have a major role in the nuclear organization which has the potential to explain how these proteins can act as tumor suppressors, promoters of differentiation and barriers to somatic cell reprogramming.

We discuss these topics, the mission of the Josep Carreras Leukaemia Research Institute, and much more in this episode.

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Episoder(170)

H3K79 Methylation, DOT1L, and FOXG1 in Neural Development (Tanja Vogel)

H3K79 Methylation, DOT1L, and FOXG1 in Neural Development (Tanja Vogel)

In this episode of the Epigenetics Podcast, we talked with Tanja Vogel from the University Clinics Freiburg about her work on epigenetic modifications in stem cells during central nervous system devel...

30 Nov 202342min

Function of Insulators in 3D Genome Folding (Maria Gambetta)

Function of Insulators in 3D Genome Folding (Maria Gambetta)

In this episode of the Epigenetics Podcast, we talked with Maria Gambetta from the University of Lausanne about her work on the function of insulators in 3D genome folding. Maria Gambetta focuses on i...

16 Nov 202343min

Contribution of the Estrogen Receptor to Breast Cancer Progression (Jason Carroll)

Contribution of the Estrogen Receptor to Breast Cancer Progression (Jason Carroll)

In this episode of the Epigenetics Podcast, we talked with Jason Carroll from the Cambridge Research Institute about his work on contribution of estrogen receptor to breast cancer progression. The Pod...

2 Nov 202346min

Inheritance of Transcriptional Memory by Mitotic Bookmarking (Sheila Teves)

Inheritance of Transcriptional Memory by Mitotic Bookmarking (Sheila Teves)

In this episode of the Epigenetics Podcast, we caught up with Sheila Teves from the University of British Columbia to talk about her work on the inheritance of transcriptional memory by mitotic bookma...

19 Okt 202345min

Differential Methylated Regions in Autism Spectrum Disorders (Janine La Salle)

Differential Methylated Regions in Autism Spectrum Disorders (Janine La Salle)

In this episode of the Epigenetics Podcast, we talked with Janine La Salle from UC Davis about her work on differential methylated regions in autism spectrum disorders. In our discussion, Janine LaSal...

5 Okt 202340min

DNA Damage in Longevity and Ageing (Björn Schumacher)

DNA Damage in Longevity and Ageing (Björn Schumacher)

In this episode of the Epigenetics Podcast, we caught up with Björn Schumacher from the Institute for Genome Stability in Ageing and Disease at the University of Cologne to talk about his work on DNA ...

21 Sep 202349min

The Impact of Chromatin Modifiers on Disease Development and Progression (Capucine van Rechem)

The Impact of Chromatin Modifiers on Disease Development and Progression (Capucine van Rechem)

In this episode of the Epigenetics Podcast, we talked with Capucine van Rechem from Stanford University about her work on the impact of chromatin modifiers on disease development and progression. Dur...

7 Sep 202340min

Long-Range Transcriptional Control by 3D Chromosome Structure (Luca Giorgetti)

Long-Range Transcriptional Control by 3D Chromosome Structure (Luca Giorgetti)

In this episode of the Epigenetics Podcast, we caught up with Luca Giorgetti from the Friedrich Miescher Institute to hear about his work on long-range transcriptional control by 3D chromosome structu...

24 Aug 202340min

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