Influence of Histone Variants on Chromatin Structure and Metabolism (Markus Buschbeck)

Influence of Histone Variants on Chromatin Structure and Metabolism (Markus Buschbeck)

In this episode of the Epigenetics Podcast, we sat down with Marcus Buschbeck, Group Leader at the Josep Carreras Leukaemia Research Institute in Barcelona, to talk about his work on the histone variant macroH2A, its role in metabolism and how it contributes to the regulation of chromatin structure.

Histone variants equip chromatin with unique properties and show a specific genomic distribution. The histone variant macroH2A is unique in having a tripartite structure consisting of a N-terminal histone-fold, an intrinsically unstructured linker domain and a C-terminal macro domain. Recent discoveries show that macroH2A proteins have a major role in the nuclear organization which has the potential to explain how these proteins can act as tumor suppressors, promoters of differentiation and barriers to somatic cell reprogramming.

We discuss these topics, the mission of the Josep Carreras Leukaemia Research Institute, and much more in this episode.

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Episoder(170)

The Role of Hat1p in Chromatin Assembly (Mark Parthun)

The Role of Hat1p in Chromatin Assembly (Mark Parthun)

In this episode of the Epigenetics Podcast, we talked with Mark Parthun from Ohio State University about his work on the role of Hat1p in chromatin assembly. Mark Parthun shares insights into his pivo...

4 Apr 202447min

The Impact of Paternal Diet on Offspring Metabolism (Upasna Sharma)

The Impact of Paternal Diet on Offspring Metabolism (Upasna Sharma)

In this episode of the Epigenetics Podcast, we talked with Upasna Sharma from UC Santa Cruz about her work on a number of interesting projects on H2A.Z and telomeres, the impact of paternal diet on of...

21 Mar 202436min

H3K36me3, H4K16ac and Cryptic Transcription in Ageing (Weiwei Dang)

H3K36me3, H4K16ac and Cryptic Transcription in Ageing (Weiwei Dang)

In this episode of the Epigenetics Podcast, we talked with Weiwei Dang from Baylor College of Medicine about his work on molecular mechanisms of aging and the role of H3K36me3 and cryptic transcriptio...

7 Mar 202456min

Split-Pool Recognition of Interactions by Tag Extension (SPRITE) (Mitch Guttman)

Split-Pool Recognition of Interactions by Tag Extension (SPRITE) (Mitch Guttman)

In this episode of the Epigenetics Podcast, we talked with Mitch Guttman from California Institute of Technology about his work on characterising the 3D interactions of the genome using Split-Pool Rec...

22 Feb 202454min

MLL Proteins in Mixed-Lineage Leukemia (Yali Dou)

MLL Proteins in Mixed-Lineage Leukemia (Yali Dou)

In this episode of the Epigenetics Podcast, we talked with Yali Dou from Keck School of Medicine of USC about her work on MLL Proteins in Mixed-Lineage Leukemia. To start off this Interview Yali descr...

8 Feb 202436min

Sex-biased Imprinting and DNA Regulatory Landscapes During Reprogramming (Sam Buckberry)

Sex-biased Imprinting and DNA Regulatory Landscapes During Reprogramming (Sam Buckberry)

In this episode of the Epigenetics Podcast, we talked with Sam Buckberry from the Telethon Kids Institute about his work on gene imprinting, sex-biased gene expression, DNA regulatory landscapes, and ...

25 Jan 202438min

BET Proteins and Their Role in Chromosome Folding and Compartmentalization (Kyle Eagen)

BET Proteins and Their Role in Chromosome Folding and Compartmentalization (Kyle Eagen)

In this episode of the Epigenetics Podcast, we talked with Kyle Eagen from Baylor College of Medicine about his work on BET Proteins and their role in chromosome folding and compartmentalization. In t...

11 Jan 202430min

Epigenetic Underpinnings of Human Addiction (Francesca Telese & Jessica Zhou)

Epigenetic Underpinnings of Human Addiction (Francesca Telese & Jessica Zhou)

In this episode of the Epigenetics Podcast, we talked with Francesca Telese from UC San Diego and Jessica Zhou from Cold Spring Harbour about their work on the molecular underpinnings of human addicti...

21 Des 202359min

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