Enhancer-Promoter Interactions During Development (Yad Ghavi-Helm)
Epigenetics Podcast10 Feb 2022

Enhancer-Promoter Interactions During Development (Yad Ghavi-Helm)

In this episode of the Epigenetics Podcast, we caught up with Yad Ghavi-Helm from the Institut de Génomique Functionnelle de Lyon to talk about her work on enhancer-promoter interactions during development.

The Laboratory of Yad Ghavi-Helm focuses on how developmental genes are regulated by enhancers. Their work shows that developmental genes are often regulated by more than one enhancer and that those enhancers can often be located many kilobases away on the linear chromosome. Furthermore, their research also indicates that the interactions between promoters and their respective enhancers are usually established before the expression of the target gene is switched on, and that those interactions are generally stable during embryogenesis. In addition, those stable interactions seem to coincide with paused RNA Pol II being located at those promoters before gene activation.

References

  • Ghavi-Helm, Y., Michaut, M., Acker, J., Aude, J.-C., Thuriaux, P., Werner, M., & Soutourina, J. (2008). Genome-wide location analysis reveals a role of TFIIS in RNA polymerase III transcription. Genes & Development, 22(14), 1934–1947. https://doi.org/10.1101/gad.471908

  • Ghavi-Helm, Y., Klein, F. A., Pakozdi, T., Ciglar, L., Noordermeer, D., Huber, W., & Furlong, E. E. M. (2014). Enhancer loops appear stable during development and are associated with paused polymerase. Nature, 512(7512), 96–100. https://doi.org/10.1038/nature13417

  • Ghavi-Helm, Y., Jankowski, A., Meiers, S., Viales, R. R., Korbel, J. O., & Furlong, E. E. M. (2019). Highly rearranged chromosomes reveal uncoupling between genome topology and gene expression. Nature Genetics, 51(8), 1272–1282. https://doi.org/10.1038/s41588-019-0462-3

Related Episodes

Contact

Episoder(168)

H3K36me3, H4K16ac and Cryptic Transcription in Ageing (Weiwei Dang)

H3K36me3, H4K16ac and Cryptic Transcription in Ageing (Weiwei Dang)

In this episode of the Epigenetics Podcast, we talked with Weiwei Dang from Baylor College of Medicine about his work on molecular mechanisms of aging and the role of H3K36me3 and cryptic transcriptio...

7 Mar 202456min

Split-Pool Recognition of Interactions by Tag Extension (SPRITE) (Mitch Guttman)

Split-Pool Recognition of Interactions by Tag Extension (SPRITE) (Mitch Guttman)

In this episode of the Epigenetics Podcast, we talked with Mitch Guttman from California Institute of Technology about his work on characterising the 3D interactions of the genome using Split-Pool Rec...

22 Feb 202454min

MLL Proteins in Mixed-Lineage Leukemia (Yali Dou)

MLL Proteins in Mixed-Lineage Leukemia (Yali Dou)

In this episode of the Epigenetics Podcast, we talked with Yali Dou from Keck School of Medicine of USC about her work on MLL Proteins in Mixed-Lineage Leukemia. To start off this Interview Yali descr...

8 Feb 202436min

Sex-biased Imprinting and DNA Regulatory Landscapes During Reprogramming (Sam Buckberry)

Sex-biased Imprinting and DNA Regulatory Landscapes During Reprogramming (Sam Buckberry)

In this episode of the Epigenetics Podcast, we talked with Sam Buckberry from the Telethon Kids Institute about his work on gene imprinting, sex-biased gene expression, DNA regulatory landscapes, and ...

25 Jan 202438min

BET Proteins and Their Role in Chromosome Folding and Compartmentalization (Kyle Eagen)

BET Proteins and Their Role in Chromosome Folding and Compartmentalization (Kyle Eagen)

In this episode of the Epigenetics Podcast, we talked with Kyle Eagen from Baylor College of Medicine about his work on BET Proteins and their role in chromosome folding and compartmentalization. In t...

11 Jan 202430min

Epigenetic Underpinnings of Human Addiction (Francesca Telese & Jessica Zhou)

Epigenetic Underpinnings of Human Addiction (Francesca Telese & Jessica Zhou)

In this episode of the Epigenetics Podcast, we talked with Francesca Telese from UC San Diego and Jessica Zhou from Cold Spring Harbour about their work on the molecular underpinnings of human addicti...

21 Des 202359min

H3K79 Methylation, DOT1L, and FOXG1 in Neural Development (Tanja Vogel)

H3K79 Methylation, DOT1L, and FOXG1 in Neural Development (Tanja Vogel)

In this episode of the Epigenetics Podcast, we talked with Tanja Vogel from the University Clinics Freiburg about her work on epigenetic modifications in stem cells during central nervous system devel...

30 Nov 202342min

Function of Insulators in 3D Genome Folding (Maria Gambetta)

Function of Insulators in 3D Genome Folding (Maria Gambetta)

In this episode of the Epigenetics Podcast, we talked with Maria Gambetta from the University of Lausanne about her work on the function of insulators in 3D genome folding. Maria Gambetta focuses on i...

16 Nov 202343min

Populært innen Vitenskap

fastlegen
tingenes-tilstand
rekommandert
jss
vett-og-vitenskap-med-gaute-einevoll
smart-forklart
rss-nysgjerrige-norge
rss-rekommandert
forskningno
sinnsyn
fjellsportpodden
rss-paradigmepodden
villmarksliv
pod-britannia
nordnorsk-historie
aldring-og-helse-podden
diagnose
tidlose-historier
rss-overskuddsliv
tomprat-med-gunnar-tjomlid