The Role of PHF13 in Chromatin and Transcription (Sarah Kinkley)

The Role of PHF13 in Chromatin and Transcription (Sarah Kinkley)

In this episode of the Epigenetics Podcast, we caught up with Sarah Kinkley from the Max Planck Institute of Molecular Genetics to talk about her work on PHF13 and its role in chromatin and transcription.

The Kinkley laboratory focuses mainly on unraveling the mechanism of action of the transcription factor PHF13 (PHC Finger Protein 13). PHF13 is a reader of the epigenetic mark H3K4 trimethylation which influences higher chromatin order, transcriptional regulation, and differentiation. The lab has shown that PHF13 plays a crucial role in phase separation and mitotic chromatin compaction.

References

  • Kinkley, S., Staege, H., Mohrmann, G., Rohaly, G., Schaub, T., Kremmer, E., Winterpacht, A., & Will, H. (2009). SPOC1: a novel PHD-containing protein modulating chromatin structure and mitotic chromosome condensation. Journal of cell science, 122(Pt 16), 2946–2956. https://doi.org/10.1242/jcs.047365

  • Chung, H. R., Xu, C., Fuchs, A., Mund, A., Lange, M., Staege, H., Schubert, T., Bian, C., Dunkel, I., Eberharter, A., Regnard, C., Klinker, H., Meierhofer, D., Cozzuto, L., Winterpacht, A., Di Croce, L., Min, J., Will, H., & Kinkley, S. (2016). PHF13 is a molecular reader and transcriptional co-regulator of H3K4me2/3. eLife, 5, e10607. https://doi.org/10.7554/eLife.10607

  • Connecting the Dots: PHF13 and cohesin promote polymer-polymer phase separation of chromatin into chromosomes. Francesca Rossi, Rene Buschow, Laura V. Glaser, Tobias Schubert, Hannah Staege, Astrid Grimme, Hans Will, Thorsten Milke, Martin Vingron, Andrea M. Chiariello, Sarah Kinkley. bioRxiv 2022.03.04.482956; doi: https://doi.org/10.1101/2022.03.04.482956

Related Episodes

Episoder(168)

CpG Islands, DNA Methylation, and Disease (Adrian Bird)

CpG Islands, DNA Methylation, and Disease (Adrian Bird)

In this episode of the Epigenetics Podcast, we caught up with Sir Adrian Bird, Buchanan Professor of Genetics at the University of Edinburgh to talk about his work on CpG islands, DNA methylation, and...

18 Jun 202047min

Biophysical Modeling of 3-D Genome Organization (Leonid Mirny)

Biophysical Modeling of 3-D Genome Organization (Leonid Mirny)

In this episode of the Epigenetics Podcast, we caught up with Leonid Mirny, Ph.D., from MIT to talk about his work on biophysical modeling of the 3-D structure of chromatin. Leonid Mirny was part of t...

4 Jun 202041min

From Nucleosome Structure to Function (Karolin Luger)

From Nucleosome Structure to Function (Karolin Luger)

In this episode of the Epigenetics Podcast, we caught up with Karolin Luger, Ph.D., from the University of Colorado in Boulder to talk about her work on solving the crystal structure of the nucleosome...

19 Mai 202036min

Identification of Functional Elements in the Genome (Bing Ren)

Identification of Functional Elements in the Genome (Bing Ren)

In this episode of the Epigenetics Podcast, we caught up with Bing Ren, Ph.D., from the University of California, San Diego and the Ludwig Institute for Cancer Research to talk about his work on ident...

7 Mai 202043min

Hi-C and Three-Dimensional Genome Sequencing (Erez Lieberman Aiden)

Hi-C and Three-Dimensional Genome Sequencing (Erez Lieberman Aiden)

In this episode of the Epigenetics Podcast, we caught up with Erez Lieberman Aiden, Ph.D. from Baylor College of Medicine and Rice University in Houston to talk about his work on developing Hi-C and i...

23 Apr 202047min

Chromatin Structure and Dynamics at Ribosomal RNA Genes (Tom Moss)

Chromatin Structure and Dynamics at Ribosomal RNA Genes (Tom Moss)

In this episode of the Epigenetics Podcast, we caught up with Professor Tom Moss from Université Laval in Québec City, Canada to talk about his work on the chromatin structure and dynamics at ribosoma...

24 Mar 202033min

Epigenetic Origins Of Heterogeneity And Disease (Andrew Pospisilik)

Epigenetic Origins Of Heterogeneity And Disease (Andrew Pospisilik)

In this episode of the Epigenetics Podcast, we caught up with Dr. Andrew Pospisilik from the Van Andel Institute in Grand Rapids, Michigan to talk about his work on the epigenetic origins of heterogen...

19 Feb 202033min

PIXUL: On the Leading Edge of Chromatin Shearing (Karol Bomsztyk and Tom Matula)

PIXUL: On the Leading Edge of Chromatin Shearing (Karol Bomsztyk and Tom Matula)

In this episode of the Epigenetics Podcast, we caught up with Karol Bomsztyk M.D. and Tom Matula, Ph.D. from the University of Washington and Matchstick Technologies, to talk about their work on DNA a...

28 Jan 202045min

Populært innen Vitenskap

fastlegen
tingenes-tilstand
rekommandert
tomprat-med-gunnar-tjomlid
rss-rekommandert
forskningno
jss
sinnsyn
villmarksliv
smart-forklart
rss-paradigmepodden
fjellsportpodden
diagnose
tidlose-historier
nevropodden
aldring-og-helse-podden
dekodet-2
vett-og-vitenskap-med-gaute-einevoll
grunnstoffene
rss-nysgjerrige-norge