Structural Analysis of Nucleosomes During Transcription (Lucas Farnung)

Structural Analysis of Nucleosomes During Transcription (Lucas Farnung)

In this episode of the Epigenetics Podcast, we caught up with Lucas Farnung from Harvard Medical School to talk about his work on the structural analysis of nucleosomes during transcription.

Lucas Farnung started his scientific career in Patrick Cramer's lab, trying to solve the cryo-EM structure of RNA polymerase II transcribing through a nucleosome. This project spanned some time before being published in 2018, during which time Dr. Farnung accomplished several other goals. The team solved the cryo-electron microscopy structure of Chd1 from the yeast Saccharomyces cerevisiae bound to a nucleosome at a resolution of 4.8 Å, solved the structure of the nucleosome-CHD4 chromatin remodeler, and investigated the structural basis of nucleosome transcription mediated by Chd1 and FACT. In 2021, he started his own lab and is now working on structural analysis of nucleosomes during transcription and how chromatin remodelers work on the chromatin template.

References

  • Farnung, L., Vos, S. M., Wigge, C., & Cramer, P. (2017). Nucleosome-Chd1 structure and implications for chromatin remodelling. Nature, 550(7677), 539–542. https://doi.org/10.1038/nature24046

  • Farnung, L., Vos, S. M., & Cramer, P. (2018). Structure of transcribing RNA polymerase II-nucleosome complex. Nature communications, 9(1), 5432. https://doi.org/10.1038/s41467-018-07870-y

  • Filipovski, M., Soffers, J. H. M., Vos, S. M., & Farnung, L. (2022). Structural basis of nucleosome retention during transcription elongation. Science (New York, N.Y.), 376(6599), 1313–1316. https://doi.org/10.1126/science.abo3851

Related Episodes

Episoder(171)

The Role of PHF13 in Chromatin and Transcription (Sarah Kinkley)

The Role of PHF13 in Chromatin and Transcription (Sarah Kinkley)

In this episode of the Epigenetics Podcast, we caught up with Sarah Kinkley from the Max Planck Institute of Molecular Genetics to talk about her work on PHF13 and its role in chromatin and transcript...

12 Jan 202334min

Genome Organization Mediated by RNA Polymerase II (Argyrys Papantonis)

Genome Organization Mediated by RNA Polymerase II (Argyrys Papantonis)

In this episode of the Epigenetics Podcast, we caught up with Akis Papantonis from the University Medical Center Göttingen to talk about his work on genome organisation mediated by RNA Polymerase II. ...

15 Des 202243min

The Role of Pioneer Factors Zelda and Grainyhead at the Maternal-to-Zygotic Transition (Melissa Harrison)

The Role of Pioneer Factors Zelda and Grainyhead at the Maternal-to-Zygotic Transition (Melissa Harrison)

In this episode of the Epigenetics Podcast, we caught up with Melissa Harrison from the University of Wisconsin-Madison to talk about her work on the “Pioneer” Transcription Factors - Zelda and Grainy...

1 Des 202241min

Epigenetics in Human Malaria Parasites (Elena Gómez-Diaz)

Epigenetics in Human Malaria Parasites (Elena Gómez-Diaz)

In this episode of the Epigenetics Podcast, we caught up with Elena Gomez-Diaz from the Institute of Parasitology and Biomedicine López-Neyra at the Spanish National Research Council. She share with u...

17 Nov 202237min

Bioinformatic Analysis in Epigenetics Research (Nick Pervolarakis)

Bioinformatic Analysis in Epigenetics Research (Nick Pervolarakis)

In this episode of the Epigenetics Podcast, we caught up with Nick Pervolarakis from Active Motif to talk about bioinformatic analysis in epigenetics research. While many “bench scientists” are famili...

3 Nov 202238min

Anchor-Based Bisulfite Sequencing (Ben Delatte)

Anchor-Based Bisulfite Sequencing (Ben Delatte)

In this episode of the Epigenetics Podcast, we caught up with Ben Delatte Research Scientist at Active Motif to talk about his work on Anchor Based Bisulfite Sequencing. Whole Genome Bisulfite Sequenc...

20 Okt 202232min

Enhancer Communities in Adipocyte Differentiation (Susanne Mandrup)

Enhancer Communities in Adipocyte Differentiation (Susanne Mandrup)

In this episode of the Epigenetics Podcast, we caught up with Susanne Mandrup from the University of Southern Denmark to talk about her work on the role of enhancer communities in adipocyte differenti...

6 Okt 202227min

Transposable Elements in Gene Regulation and Evolution (Marco Trizzino)

Transposable Elements in Gene Regulation and Evolution (Marco Trizzino)

In this episode of the Epigenetics Podcast, we caught up with Marco Trizzino from Thomas Jefferson University to talk about his work on transposable elements in gene regulation and evolution. Marco T...

22 Sep 202238min

Populært innen Vitenskap

fastlegen
rekommandert
tingenes-tilstand
jss
sinnsyn
rss-rekommandert
liberal-halvtime
forskningno
tomprat-med-gunnar-tjomlid
fjellsportpodden
rss-nysgjerrige-norge
villmarksliv
kvinnehelsepodden
nordnorsk-historie
rss-paradigmepodden
smart-forklart
vett-og-vitenskap-med-gaute-einevoll
nevropodden
hva-er-greia-med
aldring-og-helse-podden